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    HPSE2 heparanase 2 (inactive) [ Homo sapiens (human) ]

    Gene ID: 60495, updated on 20-Dec-2019

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The results of this study the Heparanase 2 appeared overexpressed at different stages of Alzheimer disease.

    Upregulated Expression of Heparanase and Heparanase 2 in the Brains of Alzheimer's Disease.
    García B, Martín C, García-Suárez O, Muñiz-Alonso B, Ordiales H, Fernández-Menéndez S, Santos-Juanes J, Lorente-Gea L, Castañón S, Vicente-Etxenausia I, Piña Batista KM, Ruiz-Díaz I, Caballero-Martínez MC, Merayo-Lloves J, Guerra-Merino I, Quirós LM, Fernández-Vega I.

    our results suggest that heparanase 2 functions as a tumor suppressor in bladder cancer

    Heparanase 2 expression inversely correlates with bladder carcinoma grade and stage.
    Gross-Cohen M, Feld S, Naroditsky I, Nativ O, Ilan N, Vlodavsky I., Free PMC Article

    we provide evidence that Hpa2 overexpression in head and neck cancer cells markedly reduces tumor growth

    Heparanase 2 Attenuates Head and Neck Tumor Vascularity and Growth.
    Gross-Cohen M, Feld S, Doweck I, Neufeld G, Hasson P, Arvatz G, Barash U, Naroditsky I, Ilan N, Vlodavsky I., Free PMC Article

    The most common HPA genotypes among Saudis were HPA-1 a + b- (75%), HPA-2 a + b- (62%), HPA-3 a + b- (51.5%), HPA-4 a + b- (99%), HPA-5 a + b- (76.5%), HPA-6 a + b- (100%) and HPA-15 a + b + (50%). The prevalent allele among the HPA systems was (a), except in the HPA-15 system where the (b) allele was found in 52% of the subjects.

    Gene frequency of human platelet alloantigens-1 to -6 and -15 in Saudi blood donors.
    Al-Ouda SK, Al-Banyan AA, Abdel Gader AG, Bayoumy NM, Al-Gahtani FH.

    Our findings identified these 2 genes as a novel breast cancer biomarker gene set, which may facilitate the diagnosis and treatment in breast cancer clinical therapies.

    Gene expression profiling leads to discovery of correlation of matrix metalloproteinase 11 and heparanase 2 in breast cancer progression.
    Fu J, Khaybullin R, Zhang Y, Xia A, Qi X., Free PMC Article

    HPSE2 mutations were found in one Urofacial syndrome family but not detected in patients with non-neurogenic neurogenic bladder and severe lower urinary tract dysfunction

    HPSE2 mutations in urofacial syndrome, non-neurogenic neurogenic bladder and lower urinary tract dysfunction.
    Bulum B, Özçakar ZB, Duman D, Cengiz FB, Kavaz A, Burgu B, Baskın E, Çakar N, Soygür T, Ekim M, Tekin M, Yalçınkaya F.

    Heparanase 2 is more intensely expressed in the glandular tissue of cancer than in nonneoplastic endometrium; the HPSE2 expression in the stromal tissue is higher in the nonneoplastic controls compared with cancer mainly in the secretory endometrium.

    Immunohistochemical expression of heparanases 1 and 2 in benign tissue and in invasive neoplasia of the endometrium: a case-control study.
    Signorini Filho RC, de Azevedo Focchi GR, Theodoro TR, Pinhal MA, Nicolau SM.

    autonomic neural protein implicated in bladder emptying

    Urinary tract effects of HPSE2 mutations.
    Stuart HM, Roberts NA, Hilton EN, McKenzie EA, Daly SB, Hadfield KD, Rahal JS, Gardiner NJ, Tanley SW, Lewis MA, Sites E, Angle B, Alves C, Lourenço T, Rodrigues M, Calado A, Amado M, Guerreiro N, Serras I, Beetz C, Varga RE, Silay MS, Darlow JM, Dobson MG, Barton DE, Hunziker M, Puri P, Feather SA, Goodship JA, Goodship TH, Lambert HJ, Cordell HJ, UK VUR Study Group., Saggar A, Kinali M, 4C Study Group., Lorenz C, Moeller K, Schaefer F, Bayazit AK, Weber S, Newman WG, Woolf AS., Free PMC Article

    High expression of heparanase-2 is associated significantly with gastric tumor growth and differentiation

    High expression of heparanase-2 is an independent prognostic parameter for favorable survival in gastric cancer patients.
    Zhang X, Xu S, Tan Q, Liu L.

    Data indicate that the overexpression of HPSE1 and HPSE2 in the intervertebral degenerated discs suggests a role for these factors in mediating extracellular matrix remodeling in degenerative discs during disease development.

    Expression of heparanase isoforms in intervertebral discs classified according to Pfirrmann grading system for disc degeneration.
    Rodrigues LM, Oliveira LZ, Pinhal MA.

    HPSE2 c.631T>C (p.Y211H) is a novel benign SNP and c.1628A>T (p.N543I) is the disease-causing mutation in urofacial syndrome.

    First HPSE2 missense mutation in urofacial syndrome.
    Mahmood S, Beetz C, Tahir MM, Imran M, Mumtaz R, Bassmann I, Jahic A, Malik M, Nürnberg G, Hassan SA, Rana S, Nürnberg P, Hübner CA.

    A large region of marker homozygosity was observed at 10q24, consistent with known autosomal recessive inheritance, family consanguinity and previous genetic mapping in other families with Ochoa syndrome.

    Exome capture and massively parallel sequencing identifies a novel HPSE2 mutation in a Saudi Arabian child with Ochoa (urofacial) syndrome.
    Al Badr W, Al Bader S, Otto E, Hildebrandt F, Ackley T, Peng W, Xu J, Li J, Owens KM, Bloom D, Innis JW., Free PMC Article

    Studies indicate that cathepsin L as the heparanase activating protease.

    The heparanase system and tumor metastasis: is heparanase the seed and soil?
    Arvatz G, Shafat I, Levy-Adam F, Ilan N, Vlodavsky I.

    These results indicate a regulatory effect of heparanase on TFPI and TFPI-2 in trophoblasts, suggesting a potential involvement of heparanase in early miscarriages.

    Involvement of Heparanase in early pregnancy losses.
    Nadir Y, Henig I, Naroditzky I, Paz B, Vlodavsky I, Brenner B.

    Homozygous exonic deletions, nonsense mutations, and frameshift mutations in five further unrelated families confirmed HPSE2 as the causative gene for UFS

    Mutations in HPSE2 cause urofacial syndrome.
    Daly SB, Urquhart JE, Hilton E, McKenzie EA, Kammerer RA, Lewis M, Kerr B, Stuart H, Donnai D, Long DA, Burgu B, Aydogdu O, Derbent M, Garcia-Minaur S, Reardon W, Gener B, Shalev S, Smith R, Woolf AS, Black GC, Newman WG., Free PMC Article

    We now report evidence that Heparanse 2 (HPSE2) is the culprit gene for the syndrome. Mutations with a loss of function in the Heparanase 2 (HPSE2) gene

    Loss-of-function mutations in HPSE2 cause the autosomal recessive urofacial syndrome.
    Pang J, Zhang S, Yang P, Hawkins-Lee B, Zhong J, Zhang Y, Ochoa B, Agundez JA, Voelckel MA, Fisher RB, Gu W, Xiong WC, Mei L, She JX, Wang CY., Free PMC Article

    Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

    Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article

    Results demonstrated that the effectors from heparanase peptide-immunized mice could effectively lyse various tumor cells that were heparanase positive and HLA-A*0201 matched.

    Cytotoxic T lymphocyte epitopes from human heparanase can elicit a potent anti-tumor immune response in mice.
    Tang XD, Liang GP, Li C, Wan Y, Chen T, Chen L, Yu ST, Xiong Z, Fang DC, Wang GZ, Yang SM.

    Heparanase 2 is involved in neoplastic proliferation, but it was not exclusively associated with the malignant process.

    Heparanase-2 expression in normal ovarian epithelium and in benign and malignant ovarian tumors.
    de Moura JP Jr, Nicolau SM, Stávale JN, da Silva Pinhal MA, de Matos LL, Baracat EC, de Lima GR.

    Observational study of gene-disease association. (HuGE Navigator)

    A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A., Free PMC Article

    Data suggest that loss of modified heparan sulphate in the GBM is mediated by an increased heparanase presence and may play a role in the pathogenesis of diabetes-induced proteinuria.

    Heparanase induces a differential loss of heparan sulphate domains in overt diabetic nephropathy.
    Wijnhoven TJ, van den Hoven MJ, Ding H, van Kuppevelt TH, van der Vlag J, Berden JH, Prinz RA, Lewis EJ, Schwartz M, Xu X.

    HPSE plays a role in extracellular matrix remodeling and in increasing heparin-binding growth factor release during embryo implantation.

    Decidual heparanase activity is increased during pregnancy in the baboon (Papio anubis) and in in vitro decidualization of human stromal cells.
    D'Souza SS, Fazleabas AT, Banerjee P, Sherwin JR, Sharkey AM, Farach-Carson MC, Carson DD.

    Heparanase may facilitate invasion and metastasis of gastric carcinoma cells.

    Positive association of heparanase expression with tumor invasion and lymphatic metastasis in gastric carcinoma.
    Wang Z, Xu H, Jiang L, Zhou X, Lu C, Zhang X.

    Heparanase expression seems to be involved in the invasiveness and aggressiveness of head and neck squamous cell carcinomas.

    Heparanase expression at the invasion front of human head and neck cancers and correlation with poor prognosis.
    Beckhove P, Helmke BM, Ziouta Y, Bucur M, Dörner W, Mogler C, Dyckhoff G, Herold-Mende C.

    Study demonstrating that increased heparanase expression in prostate cancer tissues is due to promoter hypomethylation and up-regulation of transcription factor EGR1.

    Increased heparanase expression is caused by promoter hypomethylation and up-regulation of transcriptional factor early growth response-1 in human prostate cancer.
    Ogishima T, Shiina H, Breault JE, Tabatabai L, Bassett WW, Enokida H, Li LC, Kawakami T, Urakami S, Ribeiro-Filho LA, Terashima M, Fujime M, Igawa M, Dahiya R.

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