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    NECTIN2 nectin cell adhesion molecule 2 [ Homo sapiens (human) ]

    Gene ID: 5819, updated on 17-Jun-2019

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Nectin-2 mutation in men with severe teratospermia

    Detection of candidate nectin gene mutations in infertile men with severe teratospermia.
    Bronson R, Mikhailik A, Schwedes J, Gnatenko D, Hatchwell E., Free PMC Article

    06/9/2018
    In the infection with 3 MLD50 (50 % mouse lethal dose), effective resistance was not observed in transgenic mice expressing nectin-2Ig.

    Comparison of the antiviral potential among soluble forms of herpes simplex virus type-2 glycoprotein D receptors, herpes virus entry mediator A, nectin-1 and nectin-2, in transgenic mice.
    Fujimoto Y, Tomioka Y, Ozaki K, Takeda K, Suyama H, Yamamoto S, Takakuwa H, Morimatsu M, Uede T, Ono E.

    09/23/2017
    Our data provide important structural and biochemical determinants responsible for the recognition of nectin-2 by TIGIT.

    Structural, mutational and biophysical studies reveal a canonical mode of molecular recognition between immune receptor TIGIT and nectin-2.
    Samanta D, Guo H, Rubinstein R, Ramagopal UA, Almo SC., Free PMC Article

    09/16/2017
    Chromosomal breakpoints involved the PVRR2 gene in 19q31 is associated with Diffuse Large B-Cell Lymphomas.

    Novel IGH and MYC Translocation Partners in Diffuse Large B-Cell Lymphomas.
    Otto C, Scholtysik R, Schmitz R, Kreuz M, Becher C, Hummel M, Rosenwald A, Trümper L, Klapper W, Siebert R, Küppers R, “Molecular Mechanisms in Malignant Lymphomas” Network Project..

    07/22/2017
    energetic basis for the TIGIT/nectin-2 interaction and revealed that an "aromatic key" of nectin-2 is critical for this interaction, whereas variations in the lock were tolerated.

    Recognition of nectin-2 by the natural killer cell receptor T cell immunoglobulin and ITIM domain (TIGIT).
    Deuss FA, Gully BS, Rossjohn J, Berry R., Free PMC Article

    07/15/2017
    PVRL2 is a plasma cholesterol-responsive gene acting at endothelial sites of vascular inflammation to regulate transendothelial migration of leukocytes.

    Poliovirus Receptor-Related 2: A Cholesterol-Responsive Gene Affecting Atherosclerosis Development by Modulating Leukocyte Migration.
    Rossignoli A, Shang MM, Gladh H, Moessinger C, Foroughi Asl H, Talukdar HA, Franzén O, Mueller S, Björkegren JL, Folestad E, Skogsberg J.

    06/24/2017
    Serum levels of nectin-2 may have diagnostic roles for colorectal cancer patients.

    Serum nectin-2 levels are diagnostic and prognostic in patients with colorectal carcinoma.
    Karabulut M, Gunaldi M, Alis H, Afsar CU, Karabulut S, Serilmez M, Akarsu C, Seyit H, Aykan NF.

    10/29/2016
    Soluble form of nectin-2 is required for exerting the resistance against HSV-2 infection.

    Accumulation of a soluble form of human nectin-2 is required for exerting the resistance against herpes simplex virus type 2 infection in transfected cells.
    Fujimoto Y, Ozaki K, Iwamori N, Takakuwa H, Ono E.

    07/2/2016
    PVRL2, TOMM40 and APOE might be associated with human longevity.

    Genetic variants in PVRL2-TOMM40-APOE region are associated with human longevity in a Han Chinese population.
    Lu F, Guan H, Gong B, Liu X, Zhu R, Wang Y, Qian J, Zhou T, Lan X, Wang P, Lin Y, Ma S, Lin H, Zhu X, Chen R, Zhu X, Shi Y, Yang Z., Free PMC Article

    12/19/2015
    Nectin-3 trans-interacts with Nectin-2 to promote lymphocyte and monocyte extravasation.

    Nectin-3 (CD113) interacts with Nectin-2 (CD112) to promote lymphocyte transendothelial migration.
    Devilard E, Xerri L, Dubreuil P, Lopez M, Reymond N., Free PMC Article

    06/21/2014
    Chorionic gonadotropin induces vascular endothelial growth factor (VEGFA)-dependent downregulation of nectin 2, which increases the endothelial permeability in the coculture system.

    Human chorionic gonadotropin controls luteal vascular permeability via vascular endothelial growth factor by down-regulation of a cascade of adhesion proteins.
    Herr D, Fraser HM, Konrad R, Holzheu I, Kreienberg R, Wulff C.

    07/6/2013
    Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion.

    Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion.
    Samanta D, Ramagopal UA, Rubinstein R, Vigdorovich V, Nathenson SG, Almo SC., Free PMC Article

    12/22/2012
    Data show that a high expression of CD112 and CD155 (DNAM-1 ligands) on leukemic blasts.

    Decreased expression of DNAM-1 on NK cells from acute myeloid leukemia patients.
    Sanchez-Correa B, Gayoso I, Bergua JM, Casado JG, Morgado S, Solana R, Tarazona R.

    06/9/2012
    a possible etiologic role of PRR2 in nonsyndromic cleft lip with or without cleft palate

    Association analysis of the poliovirus receptor related-2 gene in patients with nonsyndromic cleft lip with or without cleft palate.
    Chengle H, Kaihong D, Fuzhi B.

    01/1/2011
    Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

    Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators.., Free PMC Article

    09/15/2010
    The CD112 is highly expressed in colon carcinoma tissues and cell lines.

    [Expression of CD112 in colon carcinoma tissues and cell lines and their clinical significance].
    Wang HT, Zhang Z, Fan M, Wang L, Dong GL.

    08/16/2010
    The authors now show that human cytomegalovirus targets CD112 for proteasome-mediated degradation by 48 h post-infection, thus removing both activating ligands for DNAM-1 from the cell surface during productive infection.

    Human cytomegalovirus UL141 promotes efficient downregulation of the natural killer cell activating ligand CD112.
    Prod'homme V, Sugrue DM, Stanton RJ, Nomoto A, Davies J, Rickards CR, Cochrane D, Moore M, Wilkinson GW, Tomasec P., Free PMC Article

    08/9/2010
    TIGIT is expressed by all NK cells, it binds PVR and PVRL2 but not PVRL3, and it inhibits NK cytotoxicity

    The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity.
    Stanietsky N, Simic H, Arapovic J, Toporik A, Levy O, Novik A, Levine Z, Beiman M, Dassa L, Achdout H, Stern-Ginossar N, Tsukerman P, Jonjic S, Mandelboim O., Free PMC Article

    01/21/2010
    Crystallization and preliminary X-ray analysis of the V domain of human nectin-2 are reported.

    Crystallization and preliminary X-ray analysis of the V domain of human nectin-2.
    Qian X, Qi J, Chu F, Liu J, Li Q, Yan J., Free PMC Article

    01/21/2010
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (6) articles

    Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate.
    Nikopensius T, Jagomägi T, Krjutskov K, Tammekivi V, Saag M, Prane I, Piekuse L, Akota I, Barkane B, Krumina A, Ambrozaityte L, Matuleviciene A, Kucinskiene ZA, Lace B, Kucinskas V, Metspalu A.

    Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
    Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC.

    MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate.
    Jagomägi T, Nikopensius T, Krjutskov K, Tammekivi V, Viltrop T, Saag M, Metspalu A.

    Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators., NORDIL investigators., BRIGHT Consortium..

    No effect of APOE and PVRL2 on the clinical outcome of multiple sclerosis.
    Ramagopalan SV, Deluca GC, Morrison KM, Herrera BM, Dyment DA, Orton S, Bihoreau MT, Degenhardt A, Pugliatti M, Sadovnick AD, Sotgiu S, Ebers GC.

    Allelic association of sequence variants in the herpes virus entry mediator-B gene (PVRL2) with the severity of multiple sclerosis.
    Schmidt S, Pericak-Vance MA, Sawcer S, Barcellos LF, Hart J, Sims J, Prokop AM, van der Walt J, DeLoa C, Lincoln RR, Oksenberg JR, Compston A, Hauser SL, Haines JL, Gregory SG, Multiple Sclerosis Genetics Group., Schmidt S, Pericak-Vance MA, Sawcer S, Barcellos LF, Hart J, Sims J, Prokop AM, van der Walt J, DeLoa C, Lincoln RR, Oksenberg JR, Compston A, Hauser SL, Haines JL, Gregory SG, Multiple Sclerosis Genetics Group..

    03/13/2008
    Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)

    The poliovirus receptor related 2 (PRR2) and apolipoprotein E genes and coronary heart disease.
    Freitas EM, Phan TC, Herbison CE, Christiansen FT, Taylor RR, Van Bockxmeer FM.

    03/13/2008
    identified PVRL2 as a new recurrent partner gene of the TRA@ locus in peripheral T-cell lymphoma

    PVRL2 is translocated to the TRA@ locus in t(14;19)(q11;q13)-positive peripheral T-cell lymphomas.
    Almire C, Bertrand P, Ruminy P, Maingonnat C, Wlodarska I, Martín-Subero JI, Siebert R, Tilly H, Bastard C.

    01/21/2010
    no statistically significant association between this marker allele and non-syndromic clefting

    Linkage disequilibrium analysis of two genes mapping on OFC3: PVR and PVRL2.
    Pezzetti F, Palmieri A, Martinelli M, Scapoli L, Arlotti M, Baciliero U, Padula E, Carinci P, Caramelli E, Carinci F.

    01/21/2010
    There is an allelic association of sequence variation in PVRL2 and the severity of multiple sclerosis.

    Allelic association of sequence variants in the herpes virus entry mediator-B gene (PVRL2) with the severity of multiple sclerosis.
    Schmidt S, Pericak-Vance MA, Sawcer S, Barcellos LF, Hart J, Sims J, Prokop AM, van der Walt J, DeLoa C, Lincoln RR, Oksenberg JR, Compston A, Hauser SL, Haines JL, Gregory SG, Multiple Sclerosis Genetics Group., Schmidt S, Pericak-Vance MA, Sawcer S, Barcellos LF, Hart J, Sims J, Prokop AM, van der Walt J, DeLoa C, Lincoln RR, Oksenberg JR, Compston A, Hauser SL, Haines JL, Gregory SG, Multiple Sclerosis Genetics Group..

    01/21/2010
    CD226/CD112 (DNAM-1/Nectin-2) mast cell stimulation has a role in the allergic process

    Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process.
    Bachelet I, Munitz A, Mankutad D, Levi-Schaffer F.

    01/21/2010
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