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    MIR202 microRNA 202 [ Homo sapiens (human) ]

    Gene ID: 574448, updated on 17-Jun-2019

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    miR-202-5p could target MATN2 to induce M2 polarization involved in allergic rhinitis.

    MiR-202-5p Promotes M2 Polarization in Allergic Rhinitis by Targeting MATN2.
    Wang L, Liu X, Song X, Dong L, Liu D.

    05/25/2019
    we provided the clinical relevance that miR-202 was down-regulated in Chronic myeloid leukemia (CML) patients and patients with lower miR-202 expression displayed higher HK2 expression.

    Overexpression of <i>miR-202</i> resensitizes imatinib resistant chronic myeloid leukemia cells through targetting Hexokinase 2.
    Deng Y, Li X, Feng J, Zhang X., Free PMC Article

    03/16/2019
    Low miR202 expression is associated with Bladder Cancer.

    miR-202 Inhibits Cell Proliferation, Migration, and Invasion by Targeting Epidermal Growth Factor Receptor in Human Bladder Cancer.
    Zhang L, Xu J, Yang G, Li H, Guo X.

    02/9/2019
    A significant decrease in miR-202 expression was observed in Non-Small Cell Lung Cancer cells both in vivo and in vitro. In addition, miR-202 expression was associated with drug resistance.

    miR-202 Enhances the Anti-Tumor Effect of Cisplatin on Non-Small Cell Lung Cancer by Targeting the Ras/MAPK Pathway.
    Sun W, Ping W, Tian Y, Zou W, Liu J, Zu Y.

    01/26/2019
    Low miR202 expression is associated with severe degenerative disc.

    MiR-202-3p regulates interleukin-1β-induced expression of matrix metalloproteinase 1 in human nucleus pulposus.
    Shi C, Wu L, Lin W, Cai Y, Zhang Y, Hu B, Gao R, Im HJ, Yuan W, Ye X, van Wijnen AJ.

    01/19/2019
    The allelic distribution of the polymorphism rs12355840 in miRNA202 was associated with caries experience in the Brazilian Manaus group. In the Ribeirao Preto group, the allelic and genotypic distributions in the polymorphism rs11362 in DEFB1 were associated with caries experience.

    Association between genetic polymorphisms in DEFB1 and microRNA202 with caries in two groups of Brazilian children.
    Oliveira DSB, Segato RAB, Oliveira S, Dutra ALT, Santos ASD, Praxedes ADN, Belém LC, Antunes LA, Lips A, Nelson-Filho P, da Silva LAB, Alves GG, Antunes LS, Küchler EC.

    12/22/2018
    Study demonstrated that miR-202-5p was a tumor-suppressive miRNA in colorectal carcinoma (CRC) progression. Also, the expression of miR-202-5p was obviously decreased in CRC tissues and associated with postoperative survival. Its overexpression inhibited the growth and metastasis of CRC cells.

    MicroRNA-202-5p functions as a tumor suppressor in colorectal carcinoma by directly targeting SMARCC1.
    Ke SB, Qiu H, Chen JM, Shi W, Chen YS.

    09/15/2018
    miR-202-3p is upregulated in type 1 gastric neuroendocrine neoplasms (g-NENs) lesions and might play important roles in the pathogenesis of type 1 g-NENs by targeting DUSP1.

    Hsa-miR-202-3p, up-regulated in type 1 gastric neuroendocrine neoplasms, may target <i>DUSP1</i>.
    Dou D, Shi YF, Liu Q, Luo J, Liu JX, Liu M, Liu YY, Li YL, Qiu XD, Tan HY., Free PMC Article

    09/15/2018
    MiR-202-3p is expressed early in gestations that develop severe preeclampsia.

    Up-regulation of microRNA-202-3p in first trimester placenta of pregnancies destined to develop severe preeclampsia, a pilot study.
    Singh K, Williams J 3rd, Brown J, Wang ET, Lee B, Gonzalez TL, Cui J, Goodarzi MO, Pisarska MD., Free PMC Article

    07/14/2018
    Genetic polymorphism in miRNA202 is involved in hBD1 salivary level as well as caries experience in children.

    Genetic Polymorphisms in DEFB1 and miRNA202 Are Involved in Salivary Human β-Defensin 1 Levels and Caries Experience in Children.
    Lips A, Antunes LS, Antunes LA, Abreu JGB, Barreiros D, Oliveira DSB, Batista AC, Nelson-Filho P, Silva LABD, Silva RABD, Alves GG, Küchler EC.

    06/30/2018
    miR-202 may function as a tumor suppressor in endometrial adenocarcinoma tumor growth by targeting FOXR2 oncogene.

    miR-202 Suppresses Cell Proliferation by Targeting FOXR2 in Endometrial Adenocarcinoma.
    Deng X, Hou C, Liang Z, Wang H, Zhu L, Xu H., Free PMC Article

    05/5/2018
    Upregulation of MTDH reversed the suppression of glioma cell growth and metastasis by miR-202.

    MicroRNA-202 inhibits cell proliferation, migration and invasion of glioma by directly targeting metadherin.
    Yang J, Fan B, Zhao Y, Fang J.

    04/28/2018
    DZNep induced miR-202-5p to target both TGFbeta receptors, TGFBR1 and TGFBR2...transfection of anti-miRNAs against miR-202-5p resulted in increased TGFBR1 and TGFBR2 protein expressions and induced EMT characteristics in these cells. In stellate pancreatic cells, miR-202 overexpression slowed growth as well as reduced stromal extracellular membrane matrix protein expression

    miR-202 Diminishes TGFβ Receptors and Attenuates TGFβ1-Induced EMT in Pancreatic Cancer.
    Mody HR, Hung SW, Pathak RK, Griffin J, Cruz-Monserrate Z, Govindarajan R., Free PMC Article

    04/21/2018
    in silico analyses suggested theG>C change of rs3821204, which located within the 3'UTR of soluble ST2 mRNA, disrupted a putative binding site for miR202-3p. Functional analyses suggested that miR-202-3p significantly decreased soluble ST2-G mRNA stability and inhibited its endogenous expression.our findings provide the first evidence that genetic variants in ST2 gene are associated with EH risk

    A functional variant in ST2 gene is associated with risk of hypertension via interfering MiR-202-3p.
    Wu F, Li L, Wen Q, Yang J, Chen Z, Wu P, He M, Zhang X, Wu T, Cheng L., Free PMC Article

    03/24/2018
    miR-202 plays an important role in regulating cell proliferation, migration and invasion of cervical cancer by directly targeting cyclin D1.

    miR-202 inhibits the progression of human cervical cancer through inhibition of cyclin D1.
    Yi Y, Li H, Lv Q, Wu K, Zhang W, Zhang J, Zhu D, Liu Q, Zhang W., Free PMC Article

    02/24/2018
    Exogenous miR202 expression reduced nonsmall cell lung cancer cell viability, migration and invasion. STAT3 was identified as a direct target gene of miR202 in nonsmall cell lung cancer.

    miR-202 functions as a tumor suppressor in non-small cell lung cancer by targeting STAT3.
    Zhao Z, Lv B, Zhang L, Zhao N, Lv Y.

    02/10/2018
    expression of miR-202 was different in the skin tissue of C57BL/6 black mice and BALB/c white mice and that wnt5a, kit, and tcf7 are negatively regulated by miR-202

    Differential Expression of miR-202 and Validation of Predicted Target Genes in the Skin Tissue of C57BL/6 Black Mice and BALB/c White Mice.
    Qu L, Li J, Zhao Z, Jiang H, Zhang Q.

    09/9/2017
    Taken together, these findings suggest that miR-202 may function as a novel tumor suppressor in ESCC by repressing cell proliferation and migration, and its biological effects may attribute the inhibition of LAMA1-mediated FAK-PI3K-Akt signaling.

    MicroRNA-202 inhibits tumor progression by targeting LAMA1 in esophageal squamous cell carcinoma.
    Meng X, Chen X, Lu P, Ma W, Yue D, Song L, Fan Q.

    05/13/2017
    Microrna-202 has a role in regulating esophageal squamous cell carcinoma apoptosis.

    miR-202 Promotes Cell Apoptosis in Esophageal Squamous Cell Carcinoma by Targeting HSF2.
    Meng X, Chen X, Lu P, Ma W, Yue D, Song L, Fan Q.

    03/18/2017
    MiR-202-3p may function as a novel pro-fibrotic miRNA in SSc by inhibition the expression of MMP1.

    MicroRNA-202-3p regulates scleroderma fibrosis by targeting matrix metalloproteinase 1.
    Zhou B, Zhu H, Luo H, Gao S, Dai X, Li Y, Zuo X.

    02/25/2017
    MALAT1 promotes gastric cancer proliferation and progression. MALAT1 is a direct target of miR-202 and knockdown of MALAT1 significantly decreases the expression of Gli2 by negatively regulating miR-202.

    Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 regulates the expression of Gli2 by miR-202 to strengthen gastric cancer progression.
    Zhang Y, Chen Z, Li MJ, Guo HY, Jing NC.

    02/18/2017
    These results suggest that miR-202 functions as a modulator that can negatively regulate BAFF by inhibiting multiple myeloma tumor cell survival, growth, and adhesion in the bone marrow microenvironment.

    miRNA-202 in bone marrow stromal cells affects the growth and adhesion of multiple myeloma cells by regulating B cell-activating factor.
    Shen X, Guo Y, Yu J, Qi J, Shi W, Wu X, Ni H, Ju S.

    02/18/2017
    High miR202 increases osteosarcoma cells resistance to apoptosis.

    TGF-β1-induced miR-202 mediates drug resistance by inhibiting apoptosis in human osteosarcoma.
    Lin Z, Song D, Wei H, Yang X, Liu T, Yan W, Xiao J.

    05/21/2016
    down regulation of miR-202 increased the expression of its target Mxd1, followed by Mxd1 recruitment to the Sin3A repressor complex and through its dimerization with Max, and increased repression of Myc-Max target proteins.

    Down regulation of miR-202 modulates Mxd1 and Sin3A repressor complexes to induce apoptosis of pancreatic cancer cells.
    Farhana L, Dawson MI, Fontana JA., Free PMC Article

    11/14/2015
    This study provides novel insight into the role of miRNA in cerebellar degeneration and suggests that miR-202 is a key miRNA mediating the pathogenesis of multiple-system atrophy.

    Altered expression of miR-202 in cerebellum of multiple-system atrophy.
    Lee ST, Chu K, Jung KH, Ban JJ, Im WS, Jo HY, Park JH, Lim JY, Shin JW, Moon J, Lee SK, Kim M, Roh JK.

    10/24/2015
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