| Rare loss-of-function mutations of PTGIR are enriched in fibromuscular dysplasia. | Rare loss-of-function mutations of PTGIR are enriched in fibromuscular dysplasia.
Georges A, Albuisson J, Berrandou T, Dupré D, Lorthioir A, D'Escamard V, Di Narzo AF, Kadian-Dodov D, Olin JW, Warchol-Celinska E, Prejbisz A, Januszewicz A, Bruneval P, Baranowska AA, Webb TR, Hamby SE, Samani NJ, Adlam D, Fendrikova-Mahlay N, Hazen S, Wang Y, Yang ML, Hunker K, Combaret N, Motreff P, Chédid A, Fiquet B, Plouin PF, Mousseaux E, Azarine A, Amar L, Azizi M, Gornik HL, Ganesh SK, Kovacic JC, Jeunemaitre X, Bouatia-Naji N., Free PMC Article | 01/8/2022 |
| these studies are not only the first to identify alpha4 helix of Rab11a as a protein binding domain on the GTPase but also reveal novel mechanistic insights into the intracellular trafficking of the human prostacyclin receptor (hIP), and potentially of other members of the GPCR superfamily, involving Rab11-dependent mechanisms. | Identification of α-helix 4 (α4) of Rab11a as a novel Rab11-binding domain (RBD): Interaction of Rab11a with the Prostacyclin Receptor.
Mulvaney EP, O'Meara F, Khan AR, O'Connell DJ, Kinsella BT. | 12/9/2017 |
| role of IP-PPARdelta signal transduction pathway in the production of sAPPalpha in cerebral microvasculature. | Role of prostacyclin signaling in endothelial production of soluble amyloid precursor protein-α in cerebral microvessels.
He T, Santhanam AV, Lu T, d'Uscio LV, Katusic ZS., Free PMC Article | 08/12/2017 |
| Data (including data from studies using transgenic mice, an murine experimental model of diabetes, and mouse/human cell lines) suggest prostaglandin I2 receptor (PTGIR) is involved in insulin secretion in pancreatic beta-cells and in permselectivity in glomerular podocytes; the mechanism appears to involve regulation of post-translational phosphorylation of nephrin. | Prostaglandin I2 Receptor Agonism Preserves β-Cell Function and Attenuates Albuminuria Through Nephrin-Dependent Mechanisms.
Batchu SN, Majumder S, Bowskill BB, White KE, Advani SL, Brijmohan AS, Liu Y, Thai K, Azizi PM, Lee WL, Advani A. | 06/10/2017 |
| The human prostacyclin receptor gene is under the transcriptional regulation of dihydrotestosterone, where this regulation is further influenced by serum-cholesterol levels. | Regulated expression of the prostacyclin receptor (IP) gene by androgens within the vasculature: Combined role for androgens and serum cholesterol.
Eivers SB, Kinsella BT. | 06/3/2017 |
| cPGI2 generates via its cognate cell-surface receptor IP-R, converting white adipocytes to brite adipocytes. | IP-receptor and PPARs trigger the conversion of human white to brite adipocyte induced by carbaprostacyclin.
Ghandour RA, Giroud M, Vegiopoulos A, Herzig S, Ailhaud G, Amri EZ, Pisani DF. | 06/11/2016 |
| these findings suggest that reduced IPR expression in DM2 platelets may contribute to platelet hyperactivity in humans with type 2 diabetes. | Prostacyclin receptor expression on platelets of humans with type 2 diabetes is inversely correlated with hemoglobin A1c levels.
Knebel SM, Sprague RS, Stephenson AH. | 12/26/2015 |
| A total of 38 non-synonymous mutations were identified within the coding region of the hIP receptor, mapping to 36 distinct residues, including several mutations previously reported to affect the signaling of the hIP receptor. | High throughput mutagenesis for identification of residues regulating human prostacyclin (hIP) receptor expression and function.
Bill A, Rosethorne EM, Kent TC, Fawcett L, Burchell L, van Diepen MT, Marelli A, Batalov S, Miraglia L, Orth AP, Renaud NA, Charlton SJ, Gosling M, Gaither LA, Groot-Kormelink PJ., Free PMC Article | 01/31/2015 |
| Prostaglandin I2- Prostaglandin I2 receptor signaling regulates human Th17 and Treg cell differentiation. | Prostaglandin I2-IP signalling regulates human Th17 and Treg cell differentiation.
Liu W, Li H, Zhang X, Wen D, Yu F, Yang S, Jia X, Cong B, Ma C. | 06/7/2014 |
| The present report is the first to show an association between the A984C polymorphism of the IP gene and platelet activation in Japanese subjects. | Effect of single nucleotide polymorphisms of the prostacyclin receptor gene on platelet activation in Japanese healthy subjects and patients with cerebral infarction.
Shimizu M, Yoshimura S, Takizawa S, Kohara S, Inoko H, Takagi S. | 01/11/2014 |
| these data provide critical insights into the transcriptional regulation of the human prostacyclin receptor gene within the vasculature, including during megakaryocytic differentiation | Regulation of the human prostacyclin receptor gene in megakaryocytes: major roles for C/EBPδ and PU.1.
Keating GL, Turner EC, Kinsella BT. | 04/27/2013 |
| IP receptor heteridimerization with thromboxane receptor facilitates receptor trafficking to membrane lipid rafts. | Heterodimerization with the prostacyclin receptor triggers thromboxane receptor relocation to lipid rafts.
Ibrahim S, McCartney A, Markosyan N, Smyth EM., Free PMC Article | 02/16/2013 |
| Prostacyclin receptor-dependent inhibition of human erythroleukemia cell differentiation is STAT3-dependent | Prostacyclin receptor-dependent inhibition of human erythroleukemia cell differentiation is STAT3-dependent.
Lau AH, Lai HK, Yeung BH, Leung SL, Tsang SY, Wong YH, Wise H. | 01/26/2013 |
| IKEPP was also found to be expressed in vascular endothelial cells where it co-localizes and complexes with the hIP | Interaction of the human prostacyclin receptor and the NHERF4 family member intestinal and kidney enriched PDZ protein (IKEPP).
Reid HM, Turner EC, Mulvaney EP, Hyland PB, McLean C, Kinsella BT. | 11/24/2012 |
| the IP receptor was expressed in blood vessels of renal cell carcinoma specimens, but not in glomerular vessels of normal renal tissue; findings suggest the IP receptor might maintain an angiogenic switch in the "on" state in tumor endothelial cells (TEC); suggest that the IP receptor is a TEC-specific marker and might be a useful therapeutic target | Prostacyclin receptor in tumor endothelial cells promotes angiogenesis in an autocrine manner.
Osawa T, Ohga N, Hida Y, Kitayama K, Akiyama K, Onodera Y, Fujie M, Shinohara N, Shindoh M, Nonomura K, Hida K., Free PMC Article | 11/24/2012 |
| VDAC is the ATP conduit in the IP receptor-mediated signaling pathway in human erythrocytes. | Prostacyclin receptor-mediated ATP release from erythrocytes requires the voltage-dependent anion channel.
Sridharan M, Bowles EA, Richards JP, Krantic M, Davis KL, Dietrich KA, Stephenson AH, Ellsworth ML, Sprague RS., Free PMC Article | 03/24/2012 |
| Human prostacyclin receptor interacts with the PDZ adapter protein PDZK1; this interaction plays important role in endothelial cell migration and angiogenesis. | Interaction of the human prostacyclin receptor with the PDZ adapter protein PDZK1: role in endothelial cell migration and angiogenesis.
Turner EC, Mulvaney EP, Reid HM, Kinsella BT., Free PMC Article | 12/31/2011 |
| study identified a novel 8 residue ER export motif within the functionally important alpha-H8 of the hIP. | Identification of a novel endoplasmic reticulum export motif within the eighth α-helical domain (α-H8) of the human prostacyclin receptor.
Donnellan PD, Kimbembe CC, Reid HM, Kinsella BT. | 07/2/2011 |
| decreased maternal plasma levels in severe preeclamptic pregnant women | Maternal levels of prostacyclin, thromboxane, ICAM, and VCAM in normal and preeclamptic pregnancies.
Lewis DF, Canzoneri BJ, Gu Y, Zhao S, Wang Y., Free PMC Article | 06/4/2011 |
| of 18 non-synonymous mutations, all with frequencies less than 2% in our study cohort, eight of the 18 had defects in binding, activation, and/or protein stability/folding | Comprehensive biochemical analysis of rare prostacyclin receptor variants: study of association of signaling with coronary artery obstruction.
Stitham J, Arehart E, Elderon L, Gleim SR, Douville K, Kasza Z, Fetalvero K, MacKenzie T, Robb J, Martin KA, Hwa J., Free PMC Article | 05/7/2011 |
| Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough.
Grilo A, Sáez-Rosas MP, Santos-Morano J, Sánchez E, Moreno-Rey C, Real LM, Ramírez-Lorca R, Sáez ME. | 12/5/2010 |
| IP(R212C) exerts a dominant action on the wild-type IP and thromboxane receptor through dimerization. This likely contributes to accelerated cardiovascular disease in individuals carrying 1 copy of the variant allele. | Dominant negative actions of human prostacyclin receptor variant through dimerization: implications for cardiovascular disease.
Ibrahim S, Tetruashvily M, Frey AJ, Wilson SJ, Stitham J, Hwa J, Smyth EM., Free PMC Article | 09/27/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observed induction of the PG receptors EP2 and IP in atherosclerotic femoral arteries in the arterial intima, medial layer, as well as the associated atherosclerotic plaque. | Prostaglandin receptors EP2 and IP are detectable in atherosclerotic arteries and plaques.
Muto A, Nishibe T, Miyauchi Y, Kondo Y, Yamamoto Y, Dardik A, Shigematsu H. | 07/12/2010 |
| The human IP gene is directly regulated by estrogen that largely occurs through an ERalpha-dependent transcriptional mechanism. | Estrogen increases expression of the human prostacyclin receptor within the vasculature through an ERalpha-dependent mechanism.
Turner EC, Kinsella BT. | 03/15/2010 |