| CircDCBLD2 alleviates liver fibrosis by regulating ferroptosis via facilitating STUB1-mediated PARK7 ubiquitination degradation. | CircDCBLD2 alleviates liver fibrosis by regulating ferroptosis via facilitating STUB1-mediated PARK7 ubiquitination degradation.
Wang J, Zhang H, Chen L, Fu K, Yan Y, Liu Z. | 03/1/2024 |
| STUB1 directs FOXQ1-mediated transactivation of Ldha gene and facilitates lactate production in mouse Sertoli cells. | STUB1 directs FOXQ1-mediated transactivation of Ldha gene and facilitates lactate production in mouse Sertoli cells.
Yang Y, Ma Y, Li M, Zhu H, Shi P, An R. | 08/25/2023 |
| CHIP inhibits odontoblast differentiation through promoting DLX3 polyubiquitylation and degradation. | CHIP inhibits odontoblast differentiation through promoting DLX3 polyubiquitylation and degradation.
Zheng H, Zhang X, Fu J, Xue Y, Chen Z, Yang G, Chen Y, Chen D, Yuan G. | 05/25/2023 |
| STUB1 regulates antiviral RNAi through inducing ubiquitination and degradation of Dicer and AGO2 in mammals. | STUB1 regulates antiviral RNAi through inducing ubiquitination and degradation of Dicer and AGO2 in mammals.
Zhang S, Zhang X, Bie Y, Kong J, Wang A, Qiu Y, Zhou X., Free PMC Article | 09/3/2022 |
| Regulation of STUB1 expression and its biological significance in mouse Sertoli cells. | Regulation of STUB1 expression and its biological significance in mouse Sertoli cells.
Li T, Zheng C, Han WJ, Chen ZZ. | 06/25/2022 |
| Stub1 maintains proteostasis of master transcription factors in embryonic stem cells. | Stub1 maintains proteostasis of master transcription factors in embryonic stem cells.
Mamun MMA, Khan MR, Zhu Y, Zhang Y, Zhou S, Xu R, Bukhari I, Thorne RF, Li J, Zhang XD, Liu G, Chen S, Wu M, Song X. | 06/18/2022 |
| CHIP ameliorates cerebral ischemia-reperfusion injury by attenuating necroptosis and inflammation. | CHIP ameliorates cerebral ischemia-reperfusion injury by attenuating necroptosis and inflammation.
Yao D, Zhang S, Hu Z, Luo H, Mao C, Fan Y, Tang M, Liu F, Shen S, Fan L, Li M, Shi J, Li J, Ma D, Xu Y, Shi C., Free PMC Article | 02/19/2022 |
| CHIP protects against MPP(+)/MPTP-induced damage by regulating Drp1 in two models of Parkinson's disease. | CHIP protects against MPP(+)/MPTP-induced damage by regulating Drp1 in two models of Parkinson's disease.
Hu Z, Mao C, Wang H, Zhang Z, Zhang S, Luo H, Tang M, Yang J, Yuan Y, Wang Y, Liu Y, Fan L, Zhang Q, Yao D, Liu F, Schisler JC, Shi C, Xu Y., Free PMC Article | 05/8/2021 |
| CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury. | CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury.
Ranek MJ, Oeing C, Sanchez-Hodge R, Kokkonen-Simon KM, Dillard D, Aslam MI, Rainer PP, Mishra S, Dunkerly-Eyring B, Holewinski RJ, Virus C, Zhang H, Mannion MM, Agrawal V, Hahn V, Lee DI, Sasaki M, Van Eyk JE, Willis MS, Page RC, Schisler JC, Kass DA., Free PMC Article | 11/28/2020 |
| Proteomic analysis of WT and CHIP KO mouse brains reveals proteins essential for maintaining energetic, redox, and mitochondrial homeostasis undergo genotype-dependent expression changes. CHIP is an essential regulator of mitochondrial number,signaling, survival. | Neuronal Preconditioning Requires the Mitophagic Activity of C-terminus of HSC70-Interacting Protein.
Lizama BN, Palubinsky AM, Raveendran VA, Moore AM, Federspiel JD, Codreanu SG, Liebler DC, McLaughlin B., Free PMC Article | 10/26/2019 |
| In summary, these results suggest that CHIP regulates AQP2 and subsequently, renal water handling. | CHIP Regulates Aquaporin-2 Quality Control and Body Water Homeostasis.
Wu Q, Moeller HB, Stevens DA, Sanchez-Hodge R, Childers G, Kortenoeven MLA, Cheng L, Rosenbaek LL, Rubel C, Patterson C, Pisitkun T, Schisler JC, Fenton RA., Free PMC Article | 09/21/2019 |
| The existence of a multiprotein complex containing UBXN2A, CHIP, and mot-2 suggests a synergistic tumor suppressor activity of UBXN2A and CHIP in mot-2-enriched tumors. | UBXN2A enhances CHIP-mediated proteasomal degradation of oncoprotein mortalin-2 in cancer cells.
Sane S, Hafner A, Srinivasan R, Masood D, Slunecka JL, Noldner CJ, Hanson AD, Kruisselbrink T, Wang X, Wang Y, Yin J, Rezvani K., Free PMC Article | 08/10/2019 |
| Study using two rodent models demonstrated that T246M mutation (described in autosomal recessive spinocerebellar ataxia-16 patients) results in structural disorganization and misfolding of the CHIP U-box domain, promoting oligomerization, and increased proteasome-dependent turnover. CHIP-T246M has no ligase activity but maintains interactions with chaperones and chaperone-related functions. | Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16.
Shi CH, Rubel C, Soss SE, Sanchez-Hodge R, Zhang S, Madrigal SC, Ravi S, McDonough H, Page RC, Chazin WJ, Patterson C, Mao CY, Willis MS, Luo HY, Li YS, Stevens DA, Tang MB, Du P, Wang YH, Hu ZW, Xu YM, Schisler JC., Free PMC Article | 01/19/2019 |
| MLL5 has a role in suppressing antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation | MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation.
Zhou P, Ding X, Wan X, Liu L, Yuan X, Zhang W, Hui X, Meng G, Xiao H, Li B, Zhong J, Hou F, Deng L, Zhang Y., Free PMC Article | 12/29/2018 |
| these findings suggest that CHIP plays a role in negative regulation of PINK1 stability and may suppress PINK1's cytoprotective effect during staurosporine-induced mammalian cell death. | The ubiquitin E3 ligase CHIP promotes proteasomal degradation of the serine/threonine protein kinase PINK1 during staurosporine-induced cell death.
Yoo L, Chung KC., Free PMC Article | 12/1/2018 |
| Results identified a new role of CHIP in adipocyte differentiation. CHIP interacts with and mediates the ubiquitylation of PPARgamma , which results in negative effects on adipogenesis. | C-terminus of HSC70-Interacting Protein (CHIP) Inhibits Adipocyte Differentiation via Ubiquitin- and Proteasome-Mediated Degradation of PPARγ.
Kim JH, Shin S, Seo J, Lee EW, Jeong M, Lee MS, Han HJ, Song J., Free PMC Article | 11/3/2018 |
| these results indicate that phosphorylation of CHIP at Ser20 by Cdk5 activation inhibits CHIP-mediated truncated apoptosis-inducing factor (tAIF) degradation, thereby contributing to tAIF-induced neuronal cell death following rotenone treatment | Cyclin-dependent kinase 5-mediated phosphorylation of CHIP promotes the tAIF-dependent death pathway in rotenone-treated cortical neurons.
Kim C, Lee J, Ko YU, Oh YJ. | 07/28/2018 |
| CHIP was as a master regulator of AQP2 degradation via HSP70 that has dual functions: (1) as chaperone for AQP2 and (2) as an anchoring protein for MDM2 E3 ligase, which is likely to be involved in AQP2 degradation. | AQP2 Abundance is Regulated by the E3-Ligase CHIP Via HSP70.
Centrone M, Ranieri M, Di Mise A, Berlingerio SP, Russo A, Deen PMT, Staub O, Valenti G, Tamma G. | 01/20/2018 |
| Consistent with reduced transcription factor EB (TFEB) activity, accumulation of phosphorylated TFEB in STUB1-deficient cells resulted in reduced autophagy and reduced mitochondrial biogenesis. These studies reveal that the ubiquitin-proteasome pathway participates in regulating autophagy and lysosomal functions by regulating the activity of TFEB. | STUB1 regulates TFEB-induced autophagy-lysosome pathway.
Sha Y, Rao L, Settembre C, Ballabio A, Eissa NT., Free PMC Article | 09/16/2017 |
| ACR interacts with proteins that regulate the ubiquitin-proteasome system, predominantly with the E3 ubiquitin-protein ligases Stub1, which binds the NH2 terminus of the ACR, and CRL4(CRBN), which is formed by Cul4a/b, Ddb1, and Crbn, and interacts with the COOH terminus of the ACR via Crbn. | Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.
Del Prete D, Rice RC, Rajadhyaksha AM, D'Adamio L., Free PMC Article | 05/6/2017 |
| The chaperone protein Hsp70 was found to be important for CHIP and NUCB1 interaction as well as CHIP-mediated NUCB1 down-regulation. | CHIP mediates down-regulation of nucleobindin-1 in preosteoblast cell line models.
Xue F, Wu Y, Zhao X, Zhao T, Meng Y, Zhao Z, Guo J, Chen W. | 02/25/2017 |
| CHIP is a negative regulator of RIPK1 and RIPK3, thus inhibiting necroptosis. | New role of E3 ubiquitin ligase in the regulation of necroptosis.
Seo J, Lee EW, Song J., Free PMC Article | 01/28/2017 |
| our study demonstrated that over-expressing miR-21 in UCBMSCs could improve neovascularization in Critical limb ischemia (CLI) through enhancing HIF-1alpha activity by targeting CHIP, which may hold great therapeutic promise in treating CLI | Human Stem Cells Overexpressing miR-21 Promote Angiogenesis in Critical Limb Ischemia by Targeting CHIP to Enhance HIF-1α Activity.
Zhou Y, Zhu Y, Zhang L, Wu T, Wu T, Zhang W, Decker AM, He J, Liu J, Wu Y, Jiang X, Zhang Z, Liang C, Zou D. | 01/14/2017 |
| PABPN1 interacts with and is stabilized by heat shock protein 90. | The Inhibition of Heat Shock Protein 90 Facilitates the Degradation of Poly-Alanine Expanded Poly (A) Binding Protein Nuclear 1 via the Carboxyl Terminus of Heat Shock Protein 70-Interacting Protein.
Shi C, Huang X, Zhang B, Zhu D, Luo H, Lu Q, Xiong WC, Mei L, Luo S., Free PMC Article | 06/11/2016 |
| CHIP is an essential regulator of neuronal bioenergetics and redox tone. | CHIP Is an Essential Determinant of Neuronal Mitochondrial Stress Signaling.
Palubinsky AM, Stankowski JN, Kale AC, Codreanu SG, Singer RJ, Liebler DC, Stanwood GD, McLaughlin B., Free PMC Article | 05/21/2016 |