Skin differentiation is impaired, and both apoptosis and cell proliferation are augmented in the absence of p23; the consequences are a severe thinning of the stratum corneum and reduced numbers of hair follicles. Since the phenotype of p23-null embryos is strikingly similar to that of embryos lacking the glucocorticoid receptor, a paradigmatic Hsp90-p23 client protein, we investigated glucocorticoid signaling. | Defective glucocorticoid receptor signaling and keratinocyte-autonomous defects contribute to skin phenotype of mouse embryos lacking the Hsp90 co-chaperone p23. Madon-Simon M, Grad I, Bayo P, Pérez P, Picard D., Free PMC Article | 09/23/2017 |
Results identified two proteins P23 and HCLS1, which were not known as RNA-binding proteins, exhibiting RNA-binding activity. | Identification of RNA-binding Proteins in Macrophages by Interactome Capture. Liepelt A, Naarmann-de Vries IS, Simons N, Eichelbaum K, Föhr S, Archer SK, Castello A, Usadel B, Krijgsveld J, Preiss T, Marx G, Hentze MW, Ostareck DH, Ostareck-Lederer A., Free PMC Article | 06/24/2017 |
we report the generation of transgenic mouse lines that overexpress wild-type p23 or uncleavable p23 | The small co-chaperone p23 overexpressing transgenic mouse. Zhang J, Spilman P, Chen S, Gorostiza O, Matalis A, Niazi K, Bredesen DE, Rao RV., Free PMC Article | 08/3/2013 |
Data support a model in which p23 and GCN5 regulate diverse multistep pathways by controlling the longevity of protein-DNA complexes. | The p23 molecular chaperone and GCN5 acetylase jointly modulate protein-DNA dynamics and open chromatin status. Zelin E, Zhang Y, Toogun OA, Zhong S, Freeman BC., Free PMC Article | 02/9/2013 |
p23 co-chaperone protects the aryl hydrocarbon receptor from degradation | p23 co-chaperone protects the aryl hydrocarbon receptor from degradation in mouse and human cell lines. Nguyen PM, Wang D, Wang Y, Li Y, Uchizono JA, Chan WK., Free PMC Article | 10/20/2012 |
Cleavage product p19 was not seen in brain samples from a mouse model of Alzheimer disease, but p23 and p19 were seen in hypoxic cultured cells experienceing endoplasmic reticulum stress. | The small chaperone protein p23 and its cleaved product p19 in cellular stress. Poksay KS, Banwait S, Crippen D, Mao X, Bredesen DE, Rao RV., Free PMC Article | 09/15/2012 |
In cytosol only one protein called p23 hsp90 binds to Bax but the binding protein does not affect the subcellular localization and pro-apoptotic activity of Bax. | Cytosolic Bax: does it require binding proteins to keep its pro-apoptotic activity in check? Vogel S, Raulf N, Bregenhorn S, Biniossek ML, Maurer U, Czabotar P, Borner C., Free PMC Article | 06/16/2012 |
The p23 cochaperone of Hsp90, which plays a major role in glucocorticoid receptor folding and function, associates with influenza virus polymerase. | Influenza virus infection induces the nuclear relocalization of the Hsp90 co-chaperone p23 and inhibits the glucocorticoid receptor response. Ge X, Rameix-Welti MA, Gault E, Chase G, dos Santos Afonso E, Picard D, Schwemmle M, Naffakh N., Free PMC Article | 12/24/2011 |
Overexpression of p23 contributes to the development of hydronephrosis through the upregulation of the aryl hydrocarbon receptor pathway in vivo. | Transgenic overexpression of p23 induces spontaneous hydronephrosis in mice. Lee J, Kim HJ, Moon JA, Sung YH, Baek IJ, Roh JI, Ha NY, Kim SY, Bahk YY, Lee JE, Yoo TH, Lee HW., Free PMC Article | 09/10/2011 |
prostaglandin E synthase (cPGES/p23) acts as a regulatory factor for expression of a PGE2-inactivating enzyme, 15-PGDH | Involvement of the constitutive prostaglandin E synthase cPGES/p23 in expression of an initial prostaglandin E2 inactivating enzyme, 15-PGDH. Nakatani Y, Hokonohara Y, Tajima Y, Kudo I, Hara S. | 07/23/2011 |
Embryos homozygous for cPGES/p23-null had lower body weights than wild-type embryos, and abnormal morphology of skin and lungs. | Knockout mice lacking cPGES/p23, a constitutively expressed PGE2 synthetic enzyme, are peri-natally lethal. Nakatani Y, Hokonohara Y, Kakuta S, Sudo K, Iwakura Y, Kudo I. | 01/21/2010 |
cPGES is required for glucocorticoid receptor function and embryonic growth but not dinoprostone biosynthesis. | cPGES/p23 is required for glucocorticoid receptor function and embryonic growth but not prostaglandin E2 synthesis. Lovgren AK, Kovarova M, Koller BH., Free PMC Article | 01/21/2010 |