| RCC2 promotes prostate cancer cell proliferation and migration through Hh/GLI1 signaling pathway and cancer stem-like cells. | RCC2 promotes prostate cancer cell proliferation and migration through Hh/GLI1 signaling pathway and cancer stem-like cells.
Wang S, Lei Z, Liu W, Xiong J, Shi Y, Yang L, Gao Q, Le K, Zhang B., Free PMC Article | 01/26/2024 |
| LncRNA HOTAIR enhances RCC2 to accelerate cervical cancer progression by sponging miR-331-3p. | LncRNA HOTAIR enhances RCC2 to accelerate cervical cancer progression by sponging miR-331-3p.
Buranjiang G, Abuduwanke A, Li X, Abulizi G. | 05/24/2023 |
| The mitotic regulator RCC2 promotes glucose metabolism through BACH1-dependent transcriptional upregulation of hexokinase II in glioma. | The mitotic regulator RCC2 promotes glucose metabolism through BACH1-dependent transcriptional upregulation of hexokinase II in glioma.
Liu T, Wang Y, Wang Y, Cheung SK, Or PM, Wong CW, Guan J, Li Z, Yang W, Tu Y, Wang J, Ho WL, Gu H, Cheng AS, Tsui SK, Chan AM. | 10/22/2022 |
| RCC2 promotes proliferation and radio-resistance in glioblastoma via activating transcription of DNMT1. | RCC2 promotes proliferation and radio-resistance in glioblastoma via activating transcription of DNMT1.
Yu H, Zhang S, Ibrahim AN, Wang J, Deng Z, Wang M. | 07/11/2020 |
| Study reports that p53 is a transcriptional regulator of RCC2 that acts through its binding to a palindromic motif in the RCC2 promoter. p53 and RCC2 signaling is important for regulation of cell migration and suppression of metastasis. | RCC2 is a novel p53 target in suppressing metastasis.
Song C, Liang L, Jin Y, Li Y, Liu Y, Guo L, Wu C, Yun CH, Yin Y., Free PMC Article | 10/20/2018 |
| RCC2 regulates apoptosis by blocking Rac1 signaling. RCC2 expression in tumor can be a useful marker for predicting chemotherapeutic response. | RCC2 over-expression in tumor cells alters apoptosis and drug sensitivity by regulating Rac1 activation.
Wu N, Ren D, Li S, Ma W, Hu S, Jin Y, Xiao S., Free PMC Article | 08/18/2018 |
| results suggest that combined exposure to CSE and PM2.5 induces LCPAT1 expression, which up-regulates autophagy, and promotes lung cancer progression via RCC2. | LncRNA LCPAT1 Mediates Smoking/ Particulate Matter 2.5-Induced Cell Autophagy and Epithelial-Mesenchymal Transition in Lung Cancer Cells via RCC2.
Lin H, Zhang X, Feng N, Wang R, Zhang W, Deng X, Wang Y, Yu X, Ye X, Li L, Qian Y, Yu H, Qian B. | 08/18/2018 |
| RCC2 plays a pivotal role in LUAD metastasis by inducing EMT via activation of MAPK-JNK signaling. | Overexpression of RCC2 Enhances Cell Motility and Promotes Tumor Metastasis in Lung Adenocarcinoma by Inducing Epithelial-Mesenchymal Transition.
Pang B, Wu N, Guan R, Pang L, Li X, Li S, Tang L, Guo Y, Chen J, Sun D, Sun H, Dai J, Bai J, Ji G, Liu P, Liu A, Wang Q, Xiao S, Fu S, Jin Y. | 05/12/2018 |
| Impaired RCC2 affects functional and clinical endpoints of colorectal cancer. High-risk patients with either MSI or MSS tumors can be identified with cost-effective routine RCC2 assays. | Regulator of Chromosome Condensation 2 Identifies High-Risk Patients within Both Major Phenotypes of Colorectal Cancer.
Bruun J, Kolberg M, Ahlquist TC, Røyrvik EC, Nome T, Leithe E, Lind GE, Merok MA, Rognum TO, Bjørkøy G, Johansen T, Lindblom A, Sun XF, Svindland A, Liestøl K, Nesbakken A, Skotheim RI, Lothe RA. | 06/28/2016 |
| RCC2 exhibits guanine exchange factor activity, in vitro and in cells, for the small GTPase RalA. RCC2 and RalA apparently work together to contribute to the regulation of kinetochore-microtubule interactions in early mitosis. | TD-60 links RalA GTPase function to the CPC in mitosis.
Papini D, Langemeyer L, Abad MA, Kerr A, Samejima I, Eyers PA, Jeyaprakash AA, Higgins JM, Barr FA, Earnshaw WC., Free PMC Article | 04/23/2016 |
| MiR-29c is downregulated in gastric carcinomas and regulates cell proliferation by targeting RCC2. | MiR-29c is downregulated in gastric carcinomas and regulates cell proliferation by targeting RCC2.
Matsuo M, Nakada C, Tsukamoto Y, Noguchi T, Uchida T, Hijiya N, Matsuura K, Moriyama M., Free PMC Article | 11/16/2013 |
| TD-60 is an essential regulator of cell cycle progression during interphase. | TD-60 is required for interphase cell cycle progression.
Yenjerla M, Panopoulos A, Reynaud C, Fotedar R, Margolis RL., Free PMC Article | 08/31/2013 |
| a complex containing cortactin and RCC2/TD60 complex that may play a functional role in cells undergoing mitosis. | Mass spectrometric analysis identifies a cortactin-RCC2/TD60 interaction in mitotic cells.
Grigera PR, Ma L, Borgman CA, Pinto AF, Sherman NE, Parsons JT, Fox JW., Free PMC Article | 07/21/2012 |
| Studies indicated that DDX21, HNRNPC, and RCC2 were isolated from Ku86 multicomponent complex in response to DNA damage. | Online nanoflow RP-RP-MS reveals dynamics of multicomponent Ku complex in response to DNA damage.
Zhou F, Cardoza JD, Ficarro SB, Adelmant GO, Lazaro JB, Marto JA., Free PMC Article | 05/28/2011 |
| Dysregulation of Rac1 and Arf6 function by RCC2 knockdown also abolished persistent migration along fibronectin fibers, indicating a functional role for RCC2 in directional cell movement. | Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.
Humphries JD, Byron A, Bass MD, Craig SE, Pinney JW, Knight D, Humphries MJ., Free PMC Article | 01/21/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits.
Stacey SN, Gudbjartsson DF, Sulem P, Bergthorsson JT, Kumar R, Thorleifsson G, Sigurdsson A, Jakobsdottir M, Sigurgeirsson B, Benediktsdottir KR, Thorisdottir K, Ragnarsson R, Scherer D, Rudnai P, Gurzau E, Koppova K, Höiom V, Botella-Estrada R, Soriano V, Juberías P, Grasa M, Carapeto FJ, Tabuenca P, Gilaberte Y, Gudmundsson J, Thorlacius S, Helgason A, Thorlacius T, Jonasdottir A, Blondal T, Gudjonsson SA, Jonsson GF, Saemundsdottir J, Kristjansson K, Bjornsdottir G, Sveinsdottir SG, Mouy M, Geller F, Nagore E, Mayordomo JI, Hansson J, Rafnar T, Kong A, Olafsson JH, Thorsteinsdottir U, Stefansson K. | 11/2/2008 |
| Data show that TD-60 is a member of the RCC1 family and that it binds preferentially the nucleotide-free form of the small G protein Rac1. | The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression.
Mollinari C, Reynaud C, Martineau-Thuillier S, Monier S, Kieffer S, Garin J, Andreassen PR, Boulet A, Goud B, Kleman JP, Margolis RL. | 01/21/2010 |