| Upregulation of PKN1 as a Prognosis Biomarker for Endometrial Cancer. | Upregulation of PKN1 as a Prognosis Biomarker for Endometrial Cancer.
Govorov I, Attarha S, Kovalevska L, Andersson E, Kashuba E, Mints M., Free PMC Article | 05/14/2022 |
| Cyclin-dependent kinase 1-mediated phosphorylation of protein kinase N1 promotes anchorage-independent growth and migration. | Cyclin-dependent kinase 1-mediated phosphorylation of protein kinase N1 promotes anchorage-independent growth and migration.
Zeng R, Wang Z, Li X, Chen Y, Yang S, Dong J. | 07/31/2021 |
| Novel roles of PRK1 and PRK2 in cilia and cancer biology. | Novel roles of PRK1 and PRK2 in cilia and cancer biology.
Patel H, Li J, Herrero A, Kroboth J, Byron A, Kriegsheim AV, Brunton V, Carragher N, Hurd T, Frame M., Free PMC Article | 11/28/2020 |
| Characterization of the novel cardiolipin binding regions identified on the protease and lipid activated PKC-related kinase 1 | Characterization of the novel cardiolipin binding regions identified on the protease and lipid activated PKC-related kinase 1.
Lin JLJ., Free PMC Article | 06/6/2020 |
| Secretory carcinoma of the skin associated with the presence of novel NFIX-PKN1 translocation. | Secretory Carcinoma of the Skin: Report of 6 Cases, Including a Case With a Novel NFIX-PKN1 Translocation.
Kastnerova L, Luzar B, Goto K, Grishakov V, Gatalica Z, Kamarachev J, Martinek P, Hájková V, Grossmann P, Imai H, Fukui H, Michal M, Kazakov DV. | 03/28/2020 |
| PKN1 transduces androgen-responsiveness to serum response factor in prostate neoplasms | Protein Kinase N1 control of androgen-responsive serum response factor action provides rationale for novel prostate cancer treatment strategy.
Venkadakrishnan VB, DePriest AD, Kumari S, Senapati D, Ben-Salem S, Su Y, Mudduluru G, Hu Q, Cortes E, Pop E, Mohler JL, Azabdaftari G, Attwood K, Shah RB, Jamieson C, Dehm SM, Magi-Galluzzi C, Klein E, Sharifi N, Liu S, Heemers HV., Free PMC Article | 01/4/2020 |
| Steady-state kinetic analysis revealed that PKN1-3 follows a sequential ordered Bi-Bi kinetic mechanism, where peptide substrate binding is preceded by ATP binding. This kinetic mechanism was confirmed by additional kinetic studies for product inhibition and affinity of small molecule inhibitors. | Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors.
Falk MD, Liu W, Bolaños B, Unsal-Kacmaz K, Klippel A, Grant S, Brooun A, Timofeevski S., Free PMC Article | 01/13/2018 |
| Pkn1 is not required for tumorigenesis initiated by loss of Pten. Triple knockout of Pten, Pkn1, and Pkn2 in mouse prostate results in squamous cell carcinoma, an uncommon but therapy-resistant form of prostate cancer. | The protein kinase C super-family member PKN is regulated by mTOR and influences differentiation during prostate cancer progression.
Yang CS, Melhuish TA, Spencer A, Ni L, Hao Y, Jividen K, Harris TE, Snow C, Frierson HF Jr, Wotton D, Paschal BM., Free PMC Article | 11/11/2017 |
| PKN1 activity was up-regulated by the active RhoA mutant (G14V) and suppressed by RhoA T19N. PKN1 siRNA interrupted the ability of RhoA to promote ESC proliferation and DNA synthesis. The effect of RhoA on ESC proliferation is mediated by activation of the PKN1-cyclin D1 pathway in vitro. | RhoA promotes epidermal stem cell proliferation via PKN1-cyclin D1 signaling.
Wang F, Zhan R, Chen L, Dai X, Wang W, Guo R, Li X, Li Z, Wang L, Huang S, Shen J, Li S, Cao C., Free PMC Article | 08/19/2017 |
| TXA2-mediated neoplastic responses in prostate adenocarcinoma PC-3 cells occur through a PRK1/PRK2-dependent mechanism. | Protein kinase C-related kinase 1 and 2 play an essential role in thromboxane-mediated neoplastic responses in prostate cancer.
O'Sullivan AG, Mulvaney EP, Hyland PB, Kinsella BT., Free PMC Article | 07/30/2016 |
| Transcriptome and interactome analyses uncover that PRK1 regulates expression of migration-relevant genes by interacting with the scaffold protein sperm-associated antigen 9 (SPAG9/JIP4). | PRK1/PKN1 controls migration and metastasis of androgen-independent prostate cancer cells.
Jilg CA, Ketscher A, Metzger E, Hummel B, Willmann D, Rüsseler V, Drendel V, Imhof A, Jung M, Franz H, Hölz S, Krönig M, Müller JM, Schüle R., Free PMC Article | 11/14/2015 |
| Data indicate that Salmonella SspH1 catalyzes the ubiquitination and proteasome-dependent degradation of PKN1 in cells. | Structure of an SspH1-PKN1 complex reveals the basis for host substrate recognition and mechanism of activation for a bacterial E3 ubiquitin ligase.
Keszei AF, Tang X, McCormick C, Zeqiraj E, Rohde JR, Tyers M, Sicheri F., Free PMC Article | 03/22/2014 |
| Protein kinase N1 inhibits Wnt/b-catenin signaling and apoptosis in melanoma cells. | Protein kinase PKN1 represses Wnt/β-catenin signaling in human melanoma cells.
James RG, Bosch KA, Kulikauskas RM, Yang PT, Robin NC, Toroni RA, Biechele TL, Berndt JD, von Haller PD, Eng JK, Wolf-Yadlin A, Chien AJ, Moon RT., Free PMC Article | 02/22/2014 |
| Protein kinase N1 is a novel substrate of NFATc1-mediated cyclin D1-CDK6 activity and modulates vascular smooth muscle cell division and migration leading to inward blood vessel wall remodeling. | Protein kinase N1 is a novel substrate of NFATc1-mediated cyclin D1-CDK6 activity and modulates vascular smooth muscle cell division and migration leading to inward blood vessel wall remodeling.
Singh NK, Kundumani-Sridharan V, Kumar S, Verma SK, Kotla S, Mukai H, Heckle MR, Rao GN., Free PMC Article | 12/29/2012 |
| PKN isoforms are not simply redundant in supporting migration, but appear to be linked through isoform specific regulatory domain properties to selective upstream signals. It | Regulatory domain selectivity in the cell-type specific PKN-dependence of cell migration.
Lachmann S, Jevons A, De Rycker M, Casamassima A, Radtke S, Collazos A, Parker PJ., Free PMC Article | 11/12/2011 |
| Data show that just one contact site as being relevant for binding of RhoA and domain from PRK1, and the HR1b domain was found not to contribute to RhoA binding. | Mutational analysis reveals a single binding interface between RhoA and its effector, PRK1.
Hutchinson CL, Lowe PN, McLaughlin SH, Mott HR, Owen D. | 08/6/2011 |
| A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in alpha1-adrenergic receptor-induced p38 activation. | A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in α1-adrenergic receptor-induced p38 activation.
Cariolato L, Cavin S, Diviani D., Free PMC Article | 05/14/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases. | Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases.
Harrison BC, Huynh K, Lundgaard GL, Helmke SM, Perryman MB, McKinsey TA. | 05/3/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesNew genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. | 04/7/2010 |
| PRK1 is present in various malignancies, but especially in ovarian serous carcinomas | PRK1 distribution in normal tissues and carcinomas: overexpression and activation in ovarian serous carcinoma.
Galgano MT, Conaway M, Spencer AM, Paschal BM, Frierson HF Jr., Free PMC Article | 01/21/2010 |
| Protein kinase C-related kinase and ROCK are required for thrombin-induced endothelial cell permeability downstream from Galpha12/13 and Galpha11/q | Protein kinase C-related kinase and ROCK are required for thrombin-induced endothelial cell permeability downstream from Galpha12/13 and Galpha11/q.
Gavard J, Gutkind JS., Free PMC Article | 01/21/2010 |
| Deregulation of PKN1 may contribute to the pathogenic process in amyotrophic lateral sclerosis. | Deregulation of PKN1 activity disrupts neurofilament organisation and axonal transport.
Manser C, Stevenson A, Banner S, Davies J, Tudor EL, Ono Y, Leigh PN, McLoughlin DM, Shaw CE, Miller CCJ., Free PMC Article | 01/21/2010 |
| Study identifies TRAF1 as a substrate of PKN1 kinase activity in vitro and in vivo, and show that this phosphorylation event is required for attenuating downstream kinase activities. | Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1.
Kato T Jr, Gotoh Y, Hoffmann A, Ono Y. | 01/21/2010 |
| Human pregnancy is characterized by increases in PKN1 expression in the myometrium. | Up-regulation of myometrial RHO effector proteins (PKN1 and DIAPH1) and CPI-17 (PPP1R14A) phosphorylation in human pregnancy is associated with increased GTP-RHOA in spontaneous preterm labor.
Lartey J, Smith M, Pawade J, Strachan B, Mellor H, López Bernal A. | 01/21/2010 |