| EDEM2 stably disulfide-bonded to TXNDC11 catalyzes the first mannose trimming step in mammalian glycoprotein ERAD. | EDEM2 stably disulfide-bonded to TXNDC11 catalyzes the first mannose trimming step in mammalian glycoprotein ERAD.
George G, Ninagawa S, Yagi H, Saito T, Ishikawa T, Sakuma T, Yamamoto T, Imami K, Ishihama Y, Kato K, Okada T, Mori K., Free PMC Article | 04/13/2021 |
| A novel gene in early childhood diabetes: EDEM2 silencing decreases SLC2A2 and PXD1 expression, leading to impaired insulin secretion. | A novel gene in early childhood diabetes: EDEM2 silencing decreases SLC2A2 and PXD1 expression, leading to impaired insulin secretion.
Alhaidan Y, Christesen HT, Højlund K, Al Balwi MA, Brusgaard K. | 08/13/2020 |
| EDEM2 and OS-9 are required for ER-associated degradation of non-glycosylated sonic hedgehog | EDEM2 and OS-9 are required for ER-associated degradation of non-glycosylated sonic hedgehog.
Tang HY, Huang CH, Zhuang YH, Christianson JC, Chen X., Free PMC Article | 06/20/2015 |
| Glycoproteins mannose trimming from Man9GlcNAc2 to Man8GlcNAc2 is conducted mainly by EDEM2. | EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step.
Ninagawa S, Okada T, Sumitomo Y, Kamiya Y, Kato K, Horimoto S, Ishikawa T, Takeda S, Sakuma T, Yamamoto T, Mori K., Free PMC Article | 10/11/2014 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study.
Tang W, Basu S, Kong X, Pankow JS, Aleksic N, Tan A, Cushman M, Boerwinkle E, Folsom AR., Free PMC Article | 09/15/2010 |
| Overexpression of EDEM2 accelerates the degradation of misfolded alpha1-antitrypsin, indicating that the protein is involved in endoplasmic reticulum associated degradation. | Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins.
Mast SW, Diekman K, Karaveg K, Davis A, Sifers RN, Moremen KW, Mast SW, Diekman K, Karaveg K, Davis A, Sifers RN, Moremen KW. | 01/21/2010 |
| EDEM2 regulates endoplasmic reticulum-associated glycoprotein degradation | A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation.
Olivari S, Galli C, Alanen H, Ruddock L, Molinari M. | 01/21/2010 |
| Degrades misfolded alpha1-antitrypsin in the ER. | Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins.
Mast SW, Diekman K, Karaveg K, Davis A, Sifers RN, Moremen KW, Mast SW, Diekman K, Karaveg K, Davis A, Sifers RN, Moremen KW. | 02/22/2005 |