| TRIM67 interacts with ENAH to regulate the apoptosis and autophagy of lung cancer cells. | TRIM67 interacts with ENAH to regulate the apoptosis and autophagy of lung cancer cells.
Liu R, Miao K, Gao L, He L. | 03/14/2024 |
| Mammalian enabled protein enhances tamoxifen sensitivity of the hormone receptor-positive breast cancer patients by suppressing the AKT signaling pathway. | Mammalian enabled protein enhances tamoxifen sensitivity of the hormone receptor-positive breast cancer patients by suppressing the AKT signaling pathway.
He L, She C, Jiang S, Qi Z, Deng Z, Ji L, Cui Y, Wu J., Free PMC Article | 03/13/2024 |
| Matrix stiffness regulates tumor cell intravasation through expression and ESRP1-mediated alternative splicing of MENA. | Matrix stiffness regulates tumor cell intravasation through expression and ESRP1-mediated alternative splicing of MENA.
Wang W, Taufalele PV, Millet M, Homsy K, Smart K, Berestesky ED, Schunk CT, Rowe MM, Bordeleau F, Reinhart-King CA., Free PMC Article | 10/6/2023 |
| Mena regulates nesprin-2 to control actin-nuclear lamina associations, trans-nuclear membrane signalling and gene expression. | Mena regulates nesprin-2 to control actin-nuclear lamina associations, trans-nuclear membrane signalling and gene expression.
Li Mow Chee F, Beernaert B, Griffith BGC, Loftus AEP, Kumar Y, Wills JC, Lee M, Valli J, Wheeler AP, Armstrong JD, Parsons M, Leigh IM, Proby CM, von Kriegsheim A, Bickmore WA, Frame MC, Byron A., Free PMC Article | 03/28/2023 |
| MiR-139-5p/ENAH Affects Progression of Hepatocellular Carcinoma Cells. | MiR-139-5p/ENAH Affects Progression of Hepatocellular Carcinoma Cells.
Zhang Y, Li M, Qiu Y, Wu Y, Chen S, Ni B, Tang D, Deng Z, Hu Z. | 11/5/2022 |
| [Screening and identification of key genes ATP1B3 and ENAH in the progression of hepatocellular carcinoma: based on data mining and clinical validation]. | [Screening and identification of key genes ATP1B3 and ENAH in the progression of hepatocellular carcinoma: based on data mining and clinical validation].
Yang X, Li Y, Wu D, Ma Y, Zhou S., Free PMC Article | 07/16/2022 |
| Enabled homolog (ENAH) regulated by RNA binding protein splicing factor 3b subunit 4 (SF3B4) exacerbates the proliferation, invasion and migration of hepatocellular carcinoma cells via Notch signaling pathway. | Enabled homolog (ENAH) regulated by RNA binding protein splicing factor 3b subunit 4 (SF3B4) exacerbates the proliferation, invasion and migration of hepatocellular carcinoma cells via Notch signaling pathway.
Deng G, Luo Y, Zhang Y, Zhang J, He Z., Free PMC Article | 02/26/2022 |
| IRSp53 is a novel interactor of SHIP2: A role of the actin binding protein Mena in their cellular localization in breast cancer cells. | IRSp53 is a novel interactor of SHIP2: A role of the actin binding protein Mena in their cellular localization in breast cancer cells.
Antoine M, Vandenbroere I, Ghosh S, Erneux C, Pirson I. | 10/30/2021 |
| Human umbilical cord mesenchymal stem cells-derived exosomes deliver microRNA-375 to downregulate ENAH and thus retard esophageal squamous cell carcinoma progression. | Human umbilical cord mesenchymal stem cells-derived exosomes deliver microRNA-375 to downregulate ENAH and thus retard esophageal squamous cell carcinoma progression.
He Z, Li W, Zheng T, Liu D, Zhao S., Free PMC Article | 04/3/2021 |
| Scaffold stiffness influences breast cancer cell invasion via EGFR-linked Mena upregulation and matrix remodeling. | Scaffold stiffness influences breast cancer cell invasion via EGFR-linked Mena upregulation and matrix remodeling.
Berger AJ, Renner CM, Hale I, Yang X, Ponik SM, Weisman PS, Masters KS, Kreeger PK., Free PMC Article | 02/13/2021 |
| Enah is upregulated in gastric cancer tissues and cell lines and is correlated with clinicopathological parameters and survival of gastric cancer patients. | Enah overexpression is correlated with poor survival and aggressive phenotype in gastric cancer.
Chen D, Xu L, Li X, Chu Y, Jiang M, Xu B, Zhao M, Wang W, Wang H, Kang H, Wang K, Wu K, Liang J, Ren G., Free PMC Article | 12/14/2019 |
| Findings show that Mena is a splicing target of PTBP1 which regulates exon11a skipping to promote lung cancer cells metastasis. | PTBP1 enhances exon11a skipping in Mena pre-mRNA to promote migration and invasion in lung carcinoma cells.
Li S, Shen L, Huang L, Lei S, Cai X, Breitzig M, Zhang B, Yang A, Ji W, Huang M, Zheng Q, Sun H, Wang F. | 11/30/2019 |
| hMENA regulates beta1 integrin expression and hMENA(11a) reduces and hMENADeltav6 increases beta1 integrin activation and signaling | hMENA isoforms impact NSCLC patient outcome through fibronectin/β1 integrin axis.
Di Modugno F, Spada S, Palermo B, Visca P, Iapicca P, Di Carlo A, Antoniani B, Sperduti I, Di Benedetto A, Terrenato I, Mottolese M, Gandolfi F, Facciolo F, Chen EI, Schwartz MA, Santoni A, Bissell MJ, Nisticò P., Free PMC Article | 03/2/2019 |
| Endothelin-1 is a regulator of Mena expression in the serous ovarian cancer.Mena expression is associated with a poor prognosis in serous ovarian cancer patients.Mena is recruited to mature invadopodia in endothelin-1 and beta-arrestin-1 signaling. | hMENA is a key regulator in endothelin-1/β-arrestin1-induced invadopodial function and metastatic process.
Di Modugno F, Caprara V, Chellini L, Tocci P, Spadaro F, Ferrandina G, Sacconi A, Blandino G, Nisticò P, Bagnato A, Rosanò L., Free PMC Article | 09/22/2018 |
| the difference between mRNAs encoding constitutive Mena sequences and those containing the 11a exon correlates with metastasis in colorectal cancer, suggesting that 11a exon exclusion contributes to invasive phenotypes and leads to poor clinical outcome | The alternatively-included 11a sequence modifies the effects of Mena on actin cytoskeletal organization and cell behavior.
Balsamo M, Mondal C, Carmona G, McClain LM, Riquelme DN, Tadros J, Ma D, Vasile E, Condeelis JS, Lauffenburger DA, Gertler FB., Free PMC Article | 05/19/2018 |
| Mena(INV) promotes invadopodium maturation by inhibiting normal dephosphorylation of cortactin at tyrosine 421 by the phosphatase PTP1B. | Mena(INV) dysregulates cortactin phosphorylation to promote invadopodium maturation.
Weidmann MD, Surve CR, Eddy RJ, Chen X, Gertler FB, Sharma VP, Condeelis JS., Free PMC Article | 05/5/2018 |
| SHIP2 recruits Mena to invadopodia and disruption of SHIP2-Mena interaction in cancer cells leads to attenuated capacity for ECM degradation and invasion in vitro, as well as reduced metastasis in vivo. | 5'-Inositol phosphatase SHIP2 recruits Mena to stabilize invadopodia for cancer cell invasion.
Rajadurai CV, Havrylov S, Coelho PP, Ratcliffe CD, Zaoui K, Huang BH, Monast A, Chughtai N, Sangwan V, Gertler FB, Siegel PM, Park M., Free PMC Article | 06/3/2017 |
| PPARgamma might inhibit the proliferation and migration of GC cell lines through suppressing the expression of TERT and ENAH | Constitutive expression of PPARγ inhibits proliferation and migration of gastric cancer cells and down-regulates Wnt/β-Catenin signaling pathway downstream target genes TERT and ENAH.
Guo F, Ren X, Dong Y, Hu X, Xu D, Zhou H, Meng F, Tian W, Zhao Y. | 08/27/2016 |
| our results indicate that hMENA11a is an anti-apoptotic regulator involved in the HER3-mediated mechanisms of resistance to PI3K inhibition in breast cancer | hMENA(11a) contributes to HER3-mediated resistance to PI3K inhibitors in HER2-overexpressing breast cancer cells.
Trono P, Di Modugno F, Circo R, Spada S, Di Benedetto A, Melchionna R, Palermo B, Matteoni S, Soddu S, Mottolese M, De Maria R, Nisticò P. | 07/30/2016 |
| these data provide the first description of endogenous Mena(INV) protein expression in mouse and human breast tumors. | Characterization of the expression of the pro-metastatic Mena(INV) isoform during breast tumor progression.
Oudin MJ, Hughes SK, Rohani N, Moufarrej MN, Jones JG, Condeelis JS, Lauffenburger DA, Gertler FB., Free PMC Article | 07/30/2016 |
| we evaluate the prognostic value of Menacalc in a cohort of ANN patients. Our primary objective was to determine if there was an association between Menacalc and overall patient mortality. | Menacalc, a quantitative method of metastasis assessment, as a prognostic marker for axillary node-negative breast cancer.
Forse CL, Agarwal S, Pinnaduwage D, Gertler F, Condeelis JS, Lin J, Xue X, Johung K, Mulligan AM, Rohan TE, Bull SB, Andrulis IL., Free PMC Article | 02/27/2016 |
| High Menacalc levels identify a subgroup of breast cancer patients with poor disease-specific survival, suggesting that Menacalc may serve as a biomarker for metastasis. | Quantitative assessment of invasive mena isoforms (Menacalc) as an independent prognostic marker in breast cancer.
Agarwal S, Gertler FB, Balsamo M, Condeelis JS, Camp RL, Xue X, Lin J, Rohan TE, Rimm DL., Free PMC Article | 07/25/2015 |
| Invasive breast ductal-carcinoma cells that migrated thru a layer of human endothelial cells were enriched for the transcript encoding Mena(INV), an invasive isoform of Mena. | Invasive breast carcinoma cells from patients exhibit MenaINV- and macrophage-dependent transendothelial migration.
Pignatelli J, Goswami S, Jones JG, Rohan TE, Pieri E, Chen X, Adler E, Cox D, Maleki S, Bresnick A, Gertler FB, Condeelis JS, Oktay MH., Free PMC Article | 07/25/2015 |
| the higher relative expression of hMena(11a) compared with hMena(INV) may predict malignant transformation in breast epithelial cells, and, furthermore, a reversal of expression of hMena(11a) and hMena(INV) may dictate the state of cancer progression | Relative expression of hMena11a and hMenaINV splice isoforms is a useful biomarker in development and progression of human breast carcinoma.
Tanaka N, Yoshida H, Suzuki Y, Harigaya K. | 05/30/2015 |
| High ENAH expression is associated with trastuzumab-resistant breast cancer. | A pathway-based approach for identifying biomarkers of tumor progression to trastuzumab-resistant breast cancer.
Nam S, Chang HR, Jung HR, Gim Y, Kim NY, Grailhe R, Seo HR, Park HS, Balch C, Lee J, Park I, Jung SY, Jeong KC, Powis G, Liang H, Lee ES, Ro J, Kim YH. | 03/7/2015 |