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    ERRFI1 ERBB receptor feedback inhibitor 1 [ Homo sapiens (human) ]

    Gene ID: 54206, updated on 21-Dec-2019

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Mig6 controls progression through mitosis. Mig6 binds to and stabilizes the Wee1 kinase.

    The Tumor Suppressor MIG6 Controls Mitotic Progression and the G2/M DNA Damage Checkpoint by Stabilizing the WEE1 Kinase.
    Sasaki M, Terabayashi T, Weiss SM, Ferby I.

    MiR-2355-5p negatively regulated ERFFI1 and prevented the effects of ERRFI1 on inhibiting NP cells proliferation and inflammation.

    ERRFI1 Inhibits Proliferation and Inflammation of Nucleus Pulposus and Is Negatively Regulated by miR-2355-5p in Intervertebral Disc Degeneration.
    Guo Y, Tian L, Liu X, He Y, Chang S, Shen Y.

    interactions of EGFR binding to phosphorylated Mig6-segment2.

    Exploring the interactions of EGFR with phosphorylated Mig6 by molecular dynamics simulations and MM-PBSA calculations.
    Zhang Y, Zheng QC.

    The NDRG1 expression potently increased the levels of mitogen-inducible gene 6 (MIG6), which inhibits EGFR and facilitates its lysosomal processing and degradation.

    The metastasis suppressor NDRG1 down-regulates the epidermal growth factor receptor via a lysosomal mechanism by up-regulating mitogen-inducible gene 6.
    Menezes SV, Kovacevic Z, Richardson DR.,

    the cells with activating mutants of EGFR inactivate Mig6 through phosphorylation at S256.

    Phosphorylation of Mig6 negatively regulates the ubiquitination and degradation of EGFR mutants in lung adenocarcinoma cell lines.
    Boopathy GTK, Lynn JLS, Wee S, Gunaratne J, Hong W.

    Importantly, in the absence of EGFR genetic alterations, miR-205/ERRFI1-driven EGFR activation rendered MET- tyrosine kinase inhibitor-resistant cells sensitive to combined MET/EGFR inhibition.

    miR-205 mediates adaptive resistance to MET inhibition via ERRFI1 targeting and raised EGFR signaling.
    Migliore C, Morando E, Ghiso E, Anastasi S, Leoni VP, Apicella M, Cora' D, Sapino A, Pietrantonio F, De Braud F, Columbano A, Segatto O, Giordano S., Free PMC Article

    Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia.

    Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia.
    Saarikoski ST, Rivera SP, Hankinson O.

    EGFR inhibition can only sensitize EGFR-high cells for chemotherapy, while AKT inhibition increases chemosensitivity in EGFR-low cells. By understanding these mechanisms, we can take advantage of the cellular context to individualize antineoplastic therapy. Finally, our data also suggest targeting of EFFRI1 in EGFR-low cancer as a promising therapeutic approach

    Differential roles of ERRFI1 in EGFR and AKT pathway regulation affect cancer proliferation.
    Cairns J, Fridley BL, Jenkins GD, Zhuang Y, Yu J, Wang L., Free PMC Article

    Study in human endometrial adenocarcinoma cell lines suggests that MIG-6 regulates AKT phosphorylation dose-dependently and interacts with AKT.

    MIG-6 suppresses endometrial epithelial cell proliferation by inhibiting phospho-AKT.
    Yoo JY, Kang HB, Broaddus RR, Risinger JI, Choi KC, Kim TH., Free PMC Article

    MIG-6 was a direct target of miR-374a, and the expression of MIG-6 was downregulated by the overexpression of miR-374a in HepG2 cells.

    MicroRNA-374a Promotes Hepatocellular Carcinoma Cell Proliferation by Targeting Mitogen-Inducible Gene 6 (MIG-6).
    Li H, Chen H, Wang H, Dong Y, Yin M, Zhang L, Wei J.

    In Ishikawa human endometrial adenocarcinoma cell line MIG-6 negatively regulates the phosphorylation of STAT3 via direct protein interaction with STAT3.

    MIG-6 negatively regulates STAT3 phosphorylation in uterine epithelial cells.
    Yoo JY, Yang WS, Lee JH, Kim BG, Broaddus RR, Lim JM, Kim TH, Jeong JW., Free PMC Article

    The regulation mechanism of MIG6 and suggests potential implications for the therapeutic strategies of gefitinib resistance through inhibiting MEF2C in hepatic cancer cells.

    MEF2C promotes gefitinib resistance in hepatic cancer cells through regulating MIG6 transcription.
    Zhang H, Liu W, Wang Z, Meng L, Wang Y, Yan H, Li L.

    Mig-6 deficiency promotes the development of Kras(G12D)-induced lung adenoma through reducing the cell apoptosis in Kras(G12D) mouse lungs partially by activating the ErbB4 pathway.

    Mig-6 deficiency cooperates with oncogenic Kras to promote mouse lung tumorigenesis.
    Liu J, Cho SN, Wu SP, Jin N, Moghaddam SJ, Gilbert JL, Wistuba I, DeMayo FJ., Free PMC Article

    Cdc42 inhibition is required for Mig-6 suppression of cell migration induced by EGF

    Inhibition of Cdc42 is essential for Mig-6 suppression of cell migration induced by EGF.
    Jiang X, Niu M, Chen D, Chen J, Cao Y, Li X, Ying H, Bergholz J, Zhang Y, Xiao ZX., Free PMC Article

    ectopic expression of Gene 33 triggers DNA damage response in an ATM serine/threonine kinase (ATM)-dependent fashion and through pathways dependent or not dependent on ABL proto-oncogene 1 non-receptor tyrosine kinase (c-Abl).

    Nuclear Gene 33/Mig6 regulates the DNA damage response through an ATM serine/threonine kinase-dependent mechanism.
    Li C, Park S, Zhang X, Eisenberg LM, Zhao H, Darzynkiewicz Z, Xu D., Free PMC Article

    our data suggest that dormant cancer cells with a high MIG6 expression level might be one of the causes of EGFR-TKI resistance in EGFR mutant lung cancer cells.

    The induction of MIG6 under hypoxic conditions is critical for dormancy in primary cultured lung cancer cells with activating EGFR mutations.
    Endo H, Okami J, Okuyama H, Nishizawa Y, Imamura F, Inoue M.

    Down-regulation of Mig-6 induces Cyclin D1 expression and activates the MAPK-ERK signaling pathway. Our study shows that the expression of Mig-6 protein is low in hepatocellular carcinoma, which predicts a poor prognosis.

    Mig-6 is down-regulated in HCC and inhibits the proliferation of HCC cells via the P-ERK/Cyclin D1 pathway.
    Li Z, Qu L, Luo W, Tian Y, Zhai H, Xu K, Zhong H.

    PIPKIgammai5, NEDD4-1, and Mig6 form a novel molecular nexus that controls EGFR activation and downstream signaling.

    Type I γ Phosphatidylinositol Phosphate 5-Kinase i5 Controls the Ubiquitination and Degradation of the Tumor Suppressor Mitogen-inducible Gene 6.
    Sun M, Cai J, Anderson RA, Sun Y., Free PMC Article

    Low MIG6 expression is associated with lung cancer.

    Gene 33/Mig6 inhibits hexavalent chromium-induced DNA damage and cell transformation in human lung epithelial cells.
    Park S, Li C, Zhao H, Darzynkiewicz Z, Xu D., Free PMC Article

    Upregulation of mitogen-inducible gene 6 triggers antitumor effect and attenuates progesterone resistance in endometrial carcinoma cells

    Upregulation of mitogen-inducible gene 6 triggers antitumor effect and attenuates progesterone resistance in endometrial carcinoma cells.
    Xu W, Zhu S, Zhou Y, Jin Y, Dai H, Wang X.

    MIG6 down regulation may promote the migration and invasiveness of MEK inhibited mutant NRAS melanoma.

    MIG6 Is MEK Regulated and Affects EGF-Induced Migration in Mutant NRAS Melanoma.
    Vu HL, Rosenbaum S, Capparelli C, Purwin TJ, Davies MA, Berger AC, Aplin AE., Free PMC Article

    MIG6 is a potent tumor suppressor for mutant EGFR-driven lung tumor initiation and progression in mice and provides a possible mechanism by which mutant EGFR can partially circumvent this tumor suppressor in human lung adenocarcinoma.

    Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor-Driven Lung Adenocarcinoma.
    Maity TK, Venugopalan A, Linnoila I, Cultraro CM, Giannakou A, Nemati R, Zhang X, Webster JD, Ritt D, Ghosal S, Hoschuetzky H, Simpson RM, Biswas R, Politi K, Morrison DK, Varmus HE, Guha U., Free PMC Article

    Crystal structures of human EGFR-Mig6 complexes show how Mig6 rearranges after phosphorylation by EGFR to effectively irreversibly inhibit the same receptor that catalyzed its phosphorylation.

    Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6.
    Park E, Kim N, Ficarro SB, Zhang Y, Lee BI, Cho A, Kim K, Park AKJ, Park WY, Murray B, Meyerson M, Beroukhim R, Marto JA, Cho J, Eck MJ., Free PMC Article

    MIG-6 efficiently reduces cellular transformation driven by oncogenic BRAF by orchestrating a negative feedback circuit directed towards the EGFR.

    Mitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant Transformation.
    Milewska M, Romano D, Herrero A, Guerriero ML, Birtwistle M, Quehenberger F, Hatzl S, Kholodenko BN, Segatto O, Kolch W, Zebisch A., Free PMC Article

    study provides a new molecular mechanism to regulate EGFR signaling through modulation of MIG6 by DNAJB1 as a negative regulator.

    DNAJB1 negatively regulates MIG6 to promote epidermal growth factor receptor signaling.
    Park SY, Choi HK, Seo JS, Yoo JY, Jeong JW, Choi Y, Choi KC, Yoon HG.

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