| Fibrinolytic and Non-fibrinolytic Roles of Tissue-type Plasminogen Activator in the Ischemic Brain. | Fibrinolytic and Non-fibrinolytic Roles of Tissue-type Plasminogen Activator in the Ischemic Brain.
Yepes M. | 03/19/2024 |
| Association of pro-fibrinolytic receptor AnnexinA2 with tissue plasminogen activator/Inhibitor-1 in pre-eclampsia. | Association of pro-fibrinolytic receptor AnnexinA2 with tissue plasminogen activator/Inhibitor-1 in pre-eclampsia.
Ruikar K, Khode V, Shetty SS, Sarathkumar E, Patil P, Patil S, Bargale A, Sadashiv R, Shetty P., Free PMC Article | 08/9/2023 |
| Correlations between the Changing Levels of Tissue Plasminogen Activator and Adiposity Following Exercise-Induced Weight Loss. | Correlations between the Changing Levels of Tissue Plasminogen Activator and Adiposity Following Exercise-Induced Weight Loss.
Zhang C, Salamon J, Zhang R., Free PMC Article | 01/11/2023 |
| Relationship between serum and tear levels of tissue plasminogen activator and plasminogen activator inhibitor-1 in diabetic retinopathy. | Relationship between serum and tear levels of tissue plasminogen activator and plasminogen activator inhibitor-1 in diabetic retinopathy.
Jasmiad NB, Abd Ghani RB, Agarwal R, Ismail ZB, Mohd Abdullah AA, Idorus MY., Free PMC Article | 09/17/2022 |
| Roles of the tissue-type plasminogen activator in immune response. | Roles of the tissue-type plasminogen activator in immune response.
Seillier C, Hélie P, Petit G, Vivien D, Clemente D, Le Mauff B, Docagne F, Toutirais O., Free PMC Article | 01/29/2022 |
| Tissue plasminogen activator is a ligand of cation-independent mannose 6-phosphate receptor and consists of glycoforms that contain mannose 6-phosphate. | Tissue plasminogen activator is a ligand of cation-independent mannose 6-phosphate receptor and consists of glycoforms that contain mannose 6-phosphate.
Miller JJ, Bohnsack RN, Olson LJ, Ishihara M, Aoki K, Tiemeyer M, Dahms NM., Free PMC Article | 12/4/2021 |
| A novel commentary: Investigation of the role of a balance between neurotrophic and apoptotic proteins in the pathogenesis of psychosis via the tPA-BDNF pathway. | A novel commentary: Investigation of the role of a balance between neurotrophic and apoptotic proteins in the pathogenesis of psychosis via the tPA-BDNF pathway.
Yesilkaya UH, Gica S, Guney Tasdemir B, Ozkara Menekseoglu P, Cirakli Z, Karamustafalioglu N. | 11/6/2021 |
| PAI-1 and tPA gene polymorphisms and susceptibility to chronic obstructive pulmonary disease in a sample of Turkish population. | PAI-1 and tPA gene polymorphisms and susceptibility to chronic obstructive pulmonary disease in a sample of Turkish population.
Sunnetcioglu A, Berkoz M, Yildirim M, Bora G, Yalin S. | 07/24/2021 |
| Recombinant Tissue Plasminogen Activator (r-tPA) Induces In-Vitro Human Neutrophil Migration via Low Density Lipoprotein Receptor-Related Protein 1 (LRP-1). | Recombinant Tissue Plasminogen Activator (r-tPA) Induces In-Vitro Human Neutrophil Migration via Low Density Lipoprotein Receptor-Related Protein 1 (LRP-1).
Liberale L, Bertolotto M, Minetti S, Contini P, Verzola D, Ameri P, Ghigliotti G, Pende A, Camici GG, Carbone F, Montecucco F., Free PMC Article | 02/27/2021 |
| Interacting hepatic PAI-1/tPA gene regulatory pathways influence impaired fibrinolysis severity in obesity. | Interacting hepatic PAI-1/tPA gene regulatory pathways influence impaired fibrinolysis severity in obesity.
Zheng Z, Nakamura K, Gershbaum S, Wang X, Thomas S, Bessler M, Schrope B, Krikhely A, Liu RM, Ozcan L, López JA, Tabas I., Free PMC Article | 02/6/2021 |
| COX4I2 and PLAT were highly correlated with blood supply in adrenal pheochromocytoma which contribute to angiogenesis in adrenal pheochromocytoma, which could be used as biomarkers to better indicate tumor angiogenesis | From clinic to mechanism: Proteomics-based assessment of angiogenesis in adrenal pheochromocytoma.
Sun F, Zhuo R, Ma W, Yang D, Su T, Ye L, Xu D, Wang W. | 06/13/2020 |
| Regulation of innate immunity by the fibrinolysis system may reflect the nature of the stimulus and a balance between the potentially opposing activities of tPA and plasmin. | Tissue-type plasminogen activator neutralizes LPS but not protease-activated receptor-mediated inflammatory responses to plasmin.
Zalfa C, Azmoon P, Mantuano E, Gonias SL., Free PMC Article | 05/9/2020 |
| the polymorphic nature of Alu DNA fragment in the human tissue plasminogen activator gene within diabetes mellitus (DM) Jordanian patients, was examined. | Alu DNA Polymorphism of Human Tissue Plasminogen Activator (tPA) Gene in Diabetic Jordanian Patients.
Yasin SR, AlHawari HH, Alassaf AA, Khadra MM, Al-Mazaydeh ZA, Al-Emerieen AF, Tahtamouni LH., Free PMC Article | 02/22/2020 |
| t-PA-mediated fibrinolysis is a transient event that resolves within 2 hours of liver graft reperfusion and is associated with increased blood product use. | Increase in post-reperfusion sensitivity to tissue plasminogen activator-mediated fibrinolysis during liver transplantation is associated with abnormal metabolic changes and increased blood product utilisation.
Moore HB, D'Alessandro A, Moore EE, Wither M, Lawson PJ, Huebner BR, Hansen K, Choudhury R, Nydam TL., Free PMC Article | 02/8/2020 |
| In macrophages, PAI1 blocked the ability of tPA to inhibit IkappaBalpha phosphorylation and cytokine expression. | PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology.
Gonias SL, Banki MA, Gilder AS, Azmoon P, Campana WM, Mantuano E., Free PMC Article | 10/26/2019 |
| Results show that the expression levels of vascular endothelial growth factor A (VEGFA), angiopoietin-2 (ANGPT2), and tissue plasminogen activator (PLAT) were suppressed in ADAM9-silenced cells, which in turn leads to decreases in angiogenesis, vascular remodeling, and tumor growth in vivo. | ADAM9 promotes lung cancer progression through vascular remodeling by VEGFA, ANGPT2, and PLAT.
Lin CY, Cho CF, Bai ST, Liu JP, Kuo TT, Wang LJ, Lin YS, Lin CC, Lai LC, Lu TP, Hsieh CY, Chu CN, Cheng DC, Sher YP., Free PMC Article | 07/13/2019 |
| The abnormal levels of PAI-1, D-dimer and tPA imply that they contribute to the exaggerated hypercoagulabilty state in pre-eclampsia thus, measuring their levels can help in the management of the condition. | Fibrinolytic proteins of normal pregnancy and pre-eclamptic patients in North West Nigeria.
Oladosu-Olayiwola O, Olawumi H, Babatunde A, Ijaiya M, Durotoye I, Biliaminu S, Ibraheem R., Free PMC Article | 04/27/2019 |
| the tPA A146Y variant not only increases the catalytic efficiency of the enzyme, but also enhances resistance to PAI-1 inhibition | tPA Point Mutation at Autolysis Loop Enhances Resistance to PAI-1 Inhibition and Catalytic Activity.
Peng S, Xue G, Chen S, Chen Z, Yuan C, Li J, Huang M. | 04/13/2019 |
| The present study suggests that both the t-PA -7351C > T and the PAI-1 4G/5G gene variants are unlikely major risk factors for central serous chorioretinopathy. | Role of the tissue-type plasminogen activator -7351C > T and plasminogen activator inhibitor 1 4G/5G gene polymorphisms in central serous chorioretinopathy.
Malle EM, Posch-Pertl L, Renner W, Pinter-Hausberger S, Singer C, Haas A, Wedrich A, Weger M. | 04/13/2019 |
| We reported for the first time to our knowledge the significant role of the two SNPs in t-PA gene (rs2020918 and rs4646972) in developing susceptibility to temporal lobe epilepsyin Chinese Han population | Role of t-PA and PAI-1 variants in temporal lobe epilepsy in Chinese Han population.
Han W, Jiang P, Guo Y, Xu P, Dang R, Li G, He X, Liao D, Yan G., Free PMC Article | 03/2/2019 |
| this study shows hypermethylation of PLAT promoter may downregulate the gene expression in nasal polyps, leading to excessive fibrin deposition by aberrant coagulation cascade | DNA Methylation of Proximal PLAT Promoter in Chronic Rhinosinusitis With Nasal Polyps.
Kidoguchi M, Noguchi E, Nakamura T, Ninomiya T, Morii W, Yoshida K, Morikawa T, Kato Y, Imoto Y, Sakashita M, Takabayashi T, Fujieda S. | 01/12/2019 |
| These findings provides evidence that gene-gene interactions between p11, tPA and BDNF are all associated with post stroke depression. | Genetic variations in the p11/tPA/BDNF pathway are associated with post stroke depression.
Liang J, Yue Y, Jiang H, Geng D, Wang J, Lu J, Li S, Zhang K, Wu A, Yuan Y. | 04/28/2018 |
| PAI-1/tPA ratio may be an important parameter to monitor the progression of OSMF, and normalizing this ratio to 1:1 may reinstate the normal healing pattern in OSMF cases | Unfavourable stoichiometry of PAI-1 and tPA foments OSMF.
Sharma M, Radhakrishnan R. | 04/14/2018 |
| The concentration of tPA/PAI-1 complex is an independent predictor of mortality from all causes and from cardiovascular causes in patients with heart failure and preserved ejection fraction. | Prognostic significance of tPA/PAI-1 complex in patients with heart failure and preserved ejection fraction.
Winter MP, Kleber ME, Koller L, Sulzgruber P, Scharnagl H, Delgado G, Goliasch G, März W, Niessner A. | 03/3/2018 |
| Underexpression of Tissue plasminogen activator is associated with diabetic foot syndrome. | Tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1) in diabetic foot syndrome.
Kulwas A, Lisewska B, Jundziłł W, Ruszkowska B, Drewniak W, Ruprecht Z, Gadomska G, Rość D. | 02/24/2018 |