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    SERPINB5 serpin family B member 5 [ Homo sapiens (human) ]

    Gene ID: 5268, updated on 16-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    SERPINB5 promotes colorectal cancer invasion and migration by promoting EMT and angiogenesis via the TNF-alpha/NF-kappaB pathway.

    SERPINB5 promotes colorectal cancer invasion and migration by promoting EMT and angiogenesis via the TNF-α/NF-κB pathway.
    Liu BX, Xie Y, Zhang J, Zeng S, Li J, Tao Q, Yang J, Chen Y, Zeng C.

    04/12/2024
    DPM1 modulates desmosomal adhesion and epidermal differentiation through SERPINB5.

    DPM1 modulates desmosomal adhesion and epidermal differentiation through SERPINB5.
    Rathod M, Franz H, Beyersdorfer V, Wanuske MT, Leal-Fischer K, Hanns P, Stüdle C, Zimmermann A, Buczak K, Schinner C, Spindler V.,

    03/15/2024
    The Role of Galectin3, Tubulinbeta, and Maspin in Promoting Tumor Budding in Colorectal Carcinoma and Their Clinical Implications.

    The Role of Galectin3, Tubulinβ, and Maspin in Promoting Tumor Budding in Colorectal Carcinoma and Their Clinical Implications.
    Elkady N, Allam DM.

    03/11/2024
    FOXA2 suppresses gallbladder carcinoma cell migration, invasion, and epithelial-mesenchymal transition by targeting SERPINB5.

    FOXA2 suppresses gallbladder carcinoma cell migration, invasion, and epithelial-mesenchymal transition by targeting SERPINB5.
    Hong L, Chen M, Huang M, Chen W, Abudukeremu X, She F, Chen Y.

    01/15/2024
    Effect of Maspin Gene Methylation Induced by Specific shRNA Sequences on the Proliferation of Oral Squamous Cell Carcinoma HN13 Cells.

    Effect of Maspin Gene Methylation Induced by Specific shRNA Sequences on the Proliferation of Oral Squamous Cell Carcinoma HN13 Cells.
    Wu J, Liu Y, Wang W, Wang H, Zhang H.

    06/22/2023
    PI3K-AKT, JAK2-STAT3 pathways and cell-cell contact regulate maspin subcellular localization.

    PI3K-AKT, JAK2-STAT3 pathways and cell-cell contact regulate maspin subcellular localization.
    Longhi MT, Silva LE, Pereira M, Magalhães M, Reina J, Vitorino FNL, Gumbiner BM, da Cunha JPC, Cella N., Free PMC Article

    02/26/2022
    Association and functional significance of genetic variants present in regulatory elements of SERPINB5 gene in gallbladder cancer.

    Association and functional significance of genetic variants present in regulatory elements of SERPINB5 gene in gallbladder cancer.
    Sinha KK, Vinay J, Parida S, Singh SP, Dixit M.

    12/4/2021
    Cytoplasmic-only Expression of Maspin Predicts Poor Prognosis in Patients With Oral Squamous Cell Carcinoma.

    Cytoplasmic-only Expression of Maspin Predicts Poor Prognosis in Patients With Oral Squamous Cell Carcinoma.
    Kawasaki M, Sakabe T, Kodani I, Umekita Y.

    09/11/2021
    The potential function of IKKalpha in gastric precancerous lesion via mediating Maspin.

    The potential function of IKKα in gastric precancerous lesion via mediating Maspin.
    Wang N, Chang LL.

    05/29/2021
    Cytoplasmic-only Expression of Maspin Predicts Unfavorable Prognosis in Patients With Pancreatic Ductal Adenocarcinoma.

    Cytoplasmic-only Expression of Maspin Predicts Unfavorable Prognosis in Patients With Pancreatic Ductal Adenocarcinoma.
    Uchinaka EI, Sakabe T, Hanaki T, Tokuyasu N, Sakamoto T, Honjo S, Fujiwara Y, Umekita Y.

    05/15/2021
    SERPINB5 Genetic Variants rs2289519 and rs2289521 are Significantly Associated with Gallbladder Cancer Risk.

    SERPINB5 Genetic Variants rs2289519 and rs2289521 are Significantly Associated with Gallbladder Cancer Risk.
    Mahananda B, Vinay J, Palo A, Singh A, Sahu SK, Singh SP, Dixit M.

    05/15/2021
    Prognostic role of maspin expression in patients with cervical dysplasia and cervical cancer.

    Prognostic role of maspin expression in patients with cervical dysplasia and cervical cancer.
    Isci Bostanci E, Guler I, Dikmen AU, Erdem O, Guner H, Onan MA, Taskiran C.

    02/6/2021
    The value of maspin and PD-L1 expression and peritumoral lymphocytic infiltration in breast tumors.

    The value of maspin and PD-L1 expression and peritumoral lymphocytic infiltration in breast tumors.
    Tuncel F, Bozkurt F, Berkesoglu M.

    02/2/2021
    Maspin expression and anti-apoptotic pathway regulation by bcl2 in laryngeal cancer.

    Maspin expression and anti-apoptotic pathway regulation by bcl2 in laryngeal cancer.
    Lovato A, Franz L, Carraro V, Bandolin L, Contro G, Ottaviano G, de Filippis C, Blandamura S, Alessandrini L, Marioni G.

    01/9/2021
    Role of class I histone deacetylases in the regulation of maspin expression in prostate cancer.

    Role of class I histone deacetylases in the regulation of maspin expression in prostate cancer.
    Shankar E, Pandey M, Verma S, Abbas A, Candamo M, Kanwal R, Shukla S, MacLennan GT, Gupta S., Free PMC Article

    10/10/2020
    TRIM21-SERPINB5-mediated guanine monophosphate synthase degradation facilitated TP53 repression, which promoted the radioresistance of nasopharyngeal carcinoma (NPC) cells. This novel working model related to TP53 suppression provided new insight into NPC radioresistence clinically.

    TRIM21-SERPINB5 aids GMPS repression to protect nasopharyngeal carcinoma cells from radiation-induced apoptosis.
    Zhang P, Li X, He Q, Zhang L, Song K, Yang X, He Q, Wang Y, Hong X, Ma J, Liu N., Free PMC Article

    07/18/2020
    This is the first study to recognize the potential implication of maspin in the pathophysiology of asthma

    Increased extracellular maspin levels after mechanical compression in vitro or allergen challenge in vivo.
    Kim SH, Mitchel JA, McGill M, Cremona TP, Baek JW, Kasahara DI, Anathy V, Israel E, Park JA., Free PMC Article

    06/20/2020
    Low maspin expression is associated with esophageal adenocarcinoma.

    Maspin differential expression patterns as a potential marker for targeted screening of esophageal adenocarcinoma/gastroesophageal junction adenocarcinoma.
    Dzinic SH, Mahdi Z, Bernardo MM, Vranic S, Beydoun H, Nahra N, Alijagic A, Harajli D, Pang A, Saliganan DM, Rahman AM, Skenderi F, Hasanbegovic B, Dyson G, Beydoun R, Sheng S., Free PMC Article

    01/11/2020
    Both MASPIN and IKKalpha are involved in the inflammatory process of OLP [Oral lichen planus ], suggesting potential therapeutic targets.

    Role of mammary serine protease inhibitor on the inflammatory response in oral lichen planus.
    Xu N, Li B, Liu Z, Gao R, Wu S, Dong Z, Li H, Yu F, Zhang F.

    01/4/2020
    High MASPIN expression is associated with gallbladder cancer.

    Significance of methylation status of MASPIN gene and its protein expression in prognosis of gallbladder cancer.
    Baghel K, Kazmi HR, Chandra A, Raj S, Srivastava RN.

    12/7/2019
    This is the first study, to our knowledge, demonstrating that maspin mRNA expression in sentinel lymph nodess is an independent predictor of non-sentinel lymph node metastasis and the presence of >/=4 LN metastases in breast cancer patients with sentinel lymph node metastasis.

    Maspin mRNA expression in sentinel lymph nodes predicts non-SLN metastasis in breast cancer patients with SLN metastasis.
    Umekita Y, Ohi Y, Iwaya O, Souda M, Sagara Y, Tamada S, Yotsumoto D, Tanimoto A.

    03/9/2019
    data suggest that maspin inhibits high glucose-induced proliferation, oxidative stress, and angiogenesis of HRMECs at least by modulating the PI3K/AKT pathway. Maspin may be a potential therapeutic agent for the prevention and treatment of proliferative diabetic retinopathy.

    Recombinant human maspin inhibits high glucose-induced oxidative stress and angiogenesis of human retinal microvascular endothelial cells via PI3K/AKT pathway.
    Qiu F, Tong H, Wang Y, Tao J, Wang H, Chen L.

    11/3/2018
    SERPINB5 may play an important role in rectal cancer progression and response to neoadjuvant CCRT and serve as a novel prognostic factor.

    SERPINB5 Expression: Association with CCRT Response and Prognostic Value in Rectal Cancer.
    Chang IW, Liu KW, Ragunanan M, He HL, Shiue YL, Yu SC., Free PMC Article

    08/25/2018
    maspin expression has a prognostic role in breast cancer. Maspin expression is related to increased angiogenesis. Subcellular localization of maspin can strongly affect cancer prognosis. Cytoplasmic maspin relates to poor prognostic parameters whereas nuclear maspin relates to good prognostic ones.

    Maspin expression and subcellular localization in invasive ductal carcinoma of the breast: Prognostic significance and relation to microvessel density.
    Helal DS, El-Guindy DM.

    07/28/2018
    Maspin nuclear expression in colorectal carcinoma buds may be helpful for a proper budding assessment and may serve as a negative prognostic factor.

    Nuclear maspin expression: A biomarker for budding assessment in colorectal cancer specimens.
    Banias L, Gurzu S, Kovacs Z, Bara T, Bara T Jr, Jung I.

    06/2/2018
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