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    P2RX5 purinergic receptor P2X 5 [ Homo sapiens (human) ]

    Gene ID: 5026, updated on 15-Jun-2019

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    sensory proteins P2X3 and TRPV1 are in correlation with urothelial differentiation, while P2X5 and TRPV4 have unique expression patterns

    Correlation between urothelial differentiation and sensory proteins P2X3, P2X5, TRPV1, and TRPV4 in normal urothelium and papillary carcinoma of human bladder.
    Sterle I, Zupančič D, Romih R., Free PMC Article

    The amino acid transporter PAT2 and the purinergic receptor P2RX5 are cell surface markers expressed in classical brown and beige adipocytes.

    ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes.
    Ussar S, Lee KY, Dankel SN, Boucher J, Haering MF, Kleinridders A, Thomou T, Xue R, Macotela Y, Cypess AM, Tseng YH, Mellgren G, Kahn CR., Free PMC Article

    These data indicate a functional role of the human P2RX5 splice variant in T cell activation and immunoregulation.

    A truncation variant of the cation channel P2RX5 is upregulated during T cell activation.
    Abramowski P, Ogrodowczyk C, Martin R, Pongs O., Free PMC Article

    These findings provide a rationale for use of LRH-1 as immunotherapeutic target antigen to treat residual or persisting myeloid malignancies after allogeneic stem cell transplantation

    Myeloid leukemic progenitor cells can be specifically targeted by minor histocompatibility antigen LRH-1-reactive cytotoxic T cells.
    Norde WJ, Overes IM, Maas F, Fredrix H, Vos JC, Kester MG, van der Voort R, Jedema I, Falkenburg JH, Schattenberg AV, de Witte TM, Dolstra H.

    Purinergic receptor P2X5 binds to adenosine triphosphate (ATP) to form a molecular complex with ASIC3 (acid-sensing ion channel number 3) to detect muscle ischemia.

    Sensing muscle ischemia: coincident detection of acid and ATP via interplay of two ion channels.
    Birdsong WT, Fierro L, Williams FG, Spelta V, Naves LA, Knowles M, Marsh-Haffner J, Adelman JP, Almers W, Elde RP, McCleskey EW., Free PMC Article

    findings indicate that most humans express only a nonfunctional isoform of P2X5, which is in stark contrast to what is seen in other vertebrate species in which P2X5 has been studied, from which only the full-length isoform is known

    Genetic and functional analysis of human P2X5 reveals a distinct pattern of exon 10 polymorphism with predominant expression of the nonfunctional receptor isoform.
    Kotnis S, Bingham B, Vasilyev DV, Miller SW, Bai Y, Yeola S, Chanda PK, Bowlby MR, Kaftan EJ, Samad TA, Whiteside GT.

    LRH-1 is aberrantly expressed on solid tumor cells

    Aberrant expression of the hematopoietic-restricted minor histocompatibility antigen LRH-1 on solid tumors results in efficient cytotoxic T cell-mediated lysis.
    Overes IM, Levenga TH, Vos JC, van Horssen-Zoetbrood A, van der Voort R, De Mulder PH, de Witte TM, Dolstra H.

    Different purinergic receptors have different functional roles in human epidermis with P2Y1 and P2Y2 receptors controlling proliferation, while P2X5 and P2X7 receptors control early differentiation, terminal differentiation and death of keratinocytes.

    Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes.
    Greig AV, Linge C, Terenghi G, McGrouther DA, Burnstock G.

    a P2X5 frameshift mutation has a role in response to treatment of chronic myeloid leukemia

    A frameshift polymorphism in P2X5 elicits an allogeneic cytotoxic T lymphocyte response associated with remission of chronic myeloid leukemia.
    de Rijke B, van Horssen-Zoetbrood A, Beekman JM, Otterud B, Maas F, Woestenenk R, Kester M, Leppert M, Schattenberg AV, de Witte T, van de Wiel-van Kemenade E, Dolstra H., Free PMC Article

    Increased keratinocyte P2X(5) receptor activity may, in part, be accountable for epidermal thinning in chronic venous insufficiency.

    Purinoceptor expression on keratinocytes reflects their function on the epidermis during chronic venous insufficiency.
    Metcalfe MJ, Baker DM, Burnstock G.

    Non-melanoma skin cancers express functional purinergic receptors and that P2X7 receptor agonists significantly reduce cell numbers in vitro.

    Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells.
    Greig AV, Linge C, Healy V, Lim P, Clayton E, Rustin MH, McGrouther DA, Burnstock G.

    analysis of topology, helix-helix interactions, and oligomerization of P2X5 subunits

    P2X5 subunit assembly requires scaffolding by the second transmembrane domain and a conserved aspartate.
    Duckwitz W, Hausmann R, Aschrafi A, Schmalzing G.

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