| NTSR1 glycosylation and MMP dependent cleavage generate three distinct forms of the protein. | NTSR1 glycosylation and MMP dependent cleavage generate three distinct forms of the protein.
Libanje F, Delille R, Young PA, Rolland S, Meyer-Losic F, Lewkowicz E, Klinz S., Free PMC Article | 04/1/2023 |
| Adding of neurotensin to non-small cell lung cancer cells increases tyrosine phosphorylation of HER3. | Adding of neurotensin to non-small cell lung cancer cells increases tyrosine phosphorylation of HER3.
Moody TW, Ramos-Alvarez I, Jensen RT., Free PMC Article | 10/8/2022 |
| Neurotensin receptor 1 signaling promotes pancreatic cancer progression. | Neurotensin receptor 1 signaling promotes pancreatic cancer progression.
Takahashi K, Ehata S, Miyauchi K, Morishita Y, Miyazawa K, Miyazono K., Free PMC Article | 11/22/2021 |
| Effect of NTSR1 on the Proliferation and Invasion of Gastric Adenocarcinoma Cells, the Underlying Mechanism, and Clinical Role. | Effect of NTSR1 on the Proliferation and Invasion of Gastric Adenocarcinoma Cells, the Underlying Mechanism, and Clinical Role.
Wang H, Huang D, Zhou Z. | 07/3/2021 |
| Feeling at home: Structure of the NTSR1-Gi complex in a lipid environment. | Feeling at home: Structure of the NTSR1-G(i) complex in a lipid environment.
Maharana J, Shukla AK., Free PMC Article | 06/26/2021 |
| Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs. | Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs.
Zhang M, Gui M, Wang ZF, Gorgulla C, Yu JJ, Wu H, Sun ZJ, Klenk C, Merklinger L, Morstein L, Hagn F, Plückthun A, Brown A, Nasr ML, Wagner G., Free PMC Article | 05/1/2021 |
| Characterisation of the Expression of Neurotensin and Its Receptors in Human Colorectal Cancer and Its Clinical Implications. | Characterisation of the Expression of Neurotensin and Its Receptors in Human Colorectal Cancer and Its Clinical Implications.
Qiu S, Nikolaou S, Zhu J, Jeffery P, Goldin R, Kinross J, Alexander JL, Rasheed S, Tekkis P, Kontovounisios C., Free PMC Article | 02/20/2021 |
| beta-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors. | β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors.
Slosky LM, Bai Y, Toth K, Ray C, Rochelle LK, Badea A, Chandrasekhar R, Pogorelov VM, Abraham DM, Atluri N, Peddibhotla S, Hedrick MP, Hershberger P, Maloney P, Yuan H, Li Z, Wetsel WC, Pinkerton AB, Barak LS, Caron MG., Free PMC Article | 01/9/2021 |
| Differential allosteric modulation within dopamine D2R - neurotensin NTS1R and D2R - serotonin 5-HT2AR receptor complexes gives bias to intracellular calcium signalling. | Differential allosteric modulation within dopamine D(2)R - neurotensin NTS1R and D(2)R - serotonin 5-HT(2A)R receptor complexes gives bias to intracellular calcium signalling.
Plach M, Schäfer T, Borroto-Escuela DO, Weikert D, Gmeiner P, Fuxe K, Friedland K., Free PMC Article | 11/21/2020 |
| Neuropeptide receptor genes GHSR and NMUR1 are candidate epigenetic biomarkers and predictors for surgically treated patients with oropharyngeal cancer. | Neuropeptide receptor genes GHSR and NMUR1 are candidate epigenetic biomarkers and predictors for surgically treated patients with oropharyngeal cancer.
Misawa K, Mima M, Satoshi Y, Misawa Y, Imai A, Mochizuki D, Nakagawa T, Kurokawa T, Oguro M, Ishikawa R, Yamaguchi Y, Endo S, Kawasaki H, Kanazawa T, Mineta H., Free PMC Article | 11/21/2020 |
| A complex structure of arrestin-2 bound to a G protein-coupled receptor. | A complex structure of arrestin-2 bound to a G protein-coupled receptor.
Yin W, Li Z, Jin M, Yin YL, de Waal PW, Pal K, Yin Y, Gao X, He Y, Gao J, Wang X, Zhang Y, Zhou H, Melcher K, Jiang Y, Cong Y, Edward Zhou X, Yu X, Eric Xu H., Free PMC Article | 09/19/2020 |
| neurotensin receptor 1 regulates the transactivation of the EGFR and HER2 in a reactive oxygen species-dependent manner | Neurotensin receptors regulate transactivation of the EGFR and HER2 in a reactive oxygen species-dependent manner.
Moody TW, Lee L, Ramos-Alvarez I, Jensen RT., Free PMC Article | 04/25/2020 |
| A novel role of NTS in the development of Castration-resistant prostate cancer with Neuroendocrine differentiation (NED), and a possible strategy to prevent the onset of NED by targeting the NTS signaling pathway. | Neurotensin and its receptors mediate neuroendocrine transdifferentiation in prostate cancer.
Zhu S, Tian H, Niu X, Wang J, Li X, Jiang N, Wen S, Chen X, Ren S, Xu C, Chang C, Flores-Morales A, Shang Z, Sun Y, Niu Y., Free PMC Article | 12/14/2019 |
| cryoelectron structures of human NTSR1 in complex with the agonist JMV449 and the heterotrimeric Gi1 protein, at a resolution of 3 A | Conformational transitions of a neurotensin receptor 1-G(i1) complex.
Kato HE, Zhang Y, Hu H, Suomivuori CM, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G., Free PMC Article | 11/30/2019 |
| NTSR1 knockdown impaired glioblastoma invasion and tumor growth through miR-494 and identified a novel mechanism by which siNTSR1 suppressed glioblastoma invasion through the miR-494/SOCS6 axis in glioblastoma. | Interference with NTSR1 Expression Exerts an Anti-Invasion Effect via the Jun/miR-494/SOCS6 Axis of Glioblastoma Cells.
Ou-Yang Q, He X, Yang A, Li B, Xu M. | 10/27/2018 |
| This study strongly suggests that the addition of NTSR1 inhibitor in combination with platinum salt-based therapy will improve the response to the drug. | Neurotensin Receptor 1 Antagonist SR48692 Improves Response to Carboplatin by Enhancing Apoptosis and Inhibiting Drug Efflux in Ovarian Cancer.
Liu J, Agopiantz M, Poupon J, Wu Z, Just PA, Borghese B, Ségal-Bendirdjian E, Gauchotte G, Gompel A, Forgez P. | 07/28/2018 |
| Patients with lung cancer have specific personality traits, and variations in the neurotensin receptor 1 gene may be involved in the biological mechanisms of the harm avoidance and reward dependence personality traits. | Preliminary study of personality traits in Chinese lung cancer patients: Modification by neurotensin receptor 1 polymorphisms.
Ma H, Cong Z, Zhang H, Tao J, Yang C, Song Z. | 07/14/2018 |
| Our findings identify promoter methylation as an important process regulating the differential expression or silencing of NTSR1/2 in Colorectal cancer (CRC) cells. Moreover, inhibition of NTSR1 repressed tumorigenic effects in CRC cells, suggesting that NTSR1 may be used as a therapeutic target for CRC. | Diverse expression patterns and tumorigenic role of neurotensin signaling components in colorectal cancer cells.
Kim JT, Weiss HL, Evers BM., Free PMC Article | 03/3/2018 |
| inducing exogenous neurotensin stimulation and enhancing NTR1 expression promoted tumor invasion rather than proliferation by accelerating epithelial-to-mesenchymal transition in hepatocellular carcinoma cells. | NTS/NTR1 co-expression enhances epithelial-to-mesenchymal transition and promotes tumor metastasis by activating the Wnt/β-catenin signaling pathway in hepatocellular carcinoma.
Ye Y, Long X, Zhang L, Chen J, Liu P, Li H, Wei F, Yu W, Ren X, Yu J., Free PMC Article | 02/24/2018 |
| High NTR1 expression is associated with pancreatic ductal adenocarcinoma. | Evaluation of neurotensin receptor 1 as a potential imaging target in pancreatic ductal adenocarcinoma.
Yin X, Wang M, Wang H, Deng H, He T, Tan Y, Zhu Z, Wu Z, Hu S, Li Z., Free PMC Article | 02/17/2018 |
| Data suggest that small molecule ligand binding to neurotensin receptor 1 (NTSR1) could facilitate the structure-based design of non-peptide ligands for the evaluation of the pharmacological potential of NTSR1 in neurological disorders and cancer. | In Silico Investigation of the Neurotensin Receptor 1 Binding Site: Overlapping Binding Modes for Small Molecule Antagonists and the Endogenous Peptide Agonist.
Lückmann M, Holst B, Schwartz TW, Frimurer TM. | 02/3/2018 |
| The results reveal a positive feedback loop between NTS/NTSR1 and Wnt/beta-Catenin signaling in glioblastoma cells that might be important for tumor development and provide potential therapeutic targets for glioblastoma. | A Novel Positive Feedback Loop Between NTSR1 and Wnt/β-Catenin Contributes to Tumor Growth of Glioblastoma.
Xiao H, Zeng Y, Wang Q, Wei S, Zhu X. | 01/27/2018 |
| NTSR1 overexpression is a poor prognostic factor in endometrial cancer, highlighting the contribution of NTS in endometrial cancer progression | Expression of neurotensin receptor 1 in endometrial adenocarcinoma is correlated with histological grade and clinical outcome.
Agopiantz M, Forgez P, Casse JM, Lacomme S, Charra-Brunaud C, Clerc-Urmès I, Morel O, Bonnet C, Guéant JL, Vignaud JM, Gompel A, Gauchotte G. | 12/9/2017 |
| characterization of the hNTS1-mediated cellular signaling network | The signaling signature of the neurotensin type 1 receptor with endogenous ligands.
Besserer-Offroy É, Brouillette RL, Lavenus S, Froehlich U, Brumwell A, Murza A, Longpré JM, Marsault É, Grandbois M, Sarret P, Leduc R. | 11/11/2017 |
| Heterodimerization of the kappa opioid receptor and neurotensin receptor 1 contributes to a novel beta-arrestin-2-signaling pathway. | Heterodimerization of the kappa opioid receptor and neurotensin receptor 1 contributes to a novel β-arrestin-2-biased pathway.
Liu H, Tian Y, Ji B, Lu H, Xin Q, Jiang Y, Ding L, Zhang J, Chen J, Bai B. | 07/1/2017 |