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    NPR3 natriuretic peptide receptor 3 [ Homo sapiens (human) ]

    Gene ID: 4883, updated on 17-Jun-2019

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    It was the aim to investigate the expression of natriuretic peptide receptors NPR-A, NPR-B and NPR-C during adipocyte differentiation (AD), upon stimulation with fatty acids (FA), and in murine and human adipose tissue depots.

    Regulation of natriuretic peptides postprandially in vivo and of their receptors in adipocytes by fatty acids in vitro.
    Schmid A, Albrecht J, Brock J, Koukou M, Arapogianni E, Schäffler A, Karrasch T.

    04/27/2019
    study identifies novel, putative mechanisms for BP-associated variants at the NPR3 locus to elevate blood pressure.

    The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle.
    Ren M, Ng FL, Warren HR, Witkowska K, Baron M, Jia Z, Cabrera C, Zhang R, Mifsud B, Munroe PB, Xiao Q, Townsend-Nicholson A, Hobbs AJ, Ye S, Caulfield MJ., Free PMC Article

    01/5/2019
    Suggest that pro-ANP/corin/NPR-C signaling is dominant in the vascular system in preeclampsia.

    Aberrant pro-atrial natriuretic peptide/corin/natriuretic peptide receptor signaling is present in maternal vascular endothelium in preeclampsia.
    Gu Y, Thompson D, Xu J, Lewis DF, Morgan JA, Cooper DB, McCathran CE, Wang Y., Free PMC Article

    09/22/2018
    NPR3 expression is downregulated by MRCCAT1 in the in metastatic clear cell renal cell carcinoma.

    Long noncoding RNA MRCCAT1 promotes metastasis of clear cell renal cell carcinoma via inhibiting NPR3 and activating p38-MAPK signaling.
    Li JK, Chen C, Liu JY, Shi JZ, Liu SP, Liu B, Wu DS, Fang ZY, Bao Y, Jiang MM, Yuan JH, Qu L, Wang LH., Free PMC Article

    08/18/2018
    This study suggested that NPR3 rs2270915 polymorphism was associated with decreased systolic blood pressure level marginally in essential hypertension patients in a Chinese Han population; the polymorphism may function through decreasing NPR3 mRNA expression and ANP level.

    Association of NPR3 polymorphism with risk of essential hypertension in a Chinese population.
    Kuang DB, Zhou JP, Li MP, Tang J, Chen XP.

    05/12/2018
    NPR-C gene single nucleotide polymorphisms significantly contribute to CAD susceptibility in the Chinese Han population

    NPR-C gene polymorphism is associated with increased susceptibility to coronary artery disease in Chinese Han population: a multicenter study.
    Hu Q, Liu Q, Wang S, Zhen X, Zhang Z, Lv R, Jiang G, Ma Z, He H, Li D, Liu X, Gao F, Li J, Li L, Zhang M, Ji X, Chen Y, Wang D, Huang D, Ma A, Huang W, Zhao Y, Gong Y, Zhang C, Zhang Y., Free PMC Article

    01/20/2018
    The NPRC genetic variant,Rs1847018, is a genetic marker of essential hypertension.

    Association of NPRA and NPRC gene variants and hypertension in Mongolian population.
    Chang PY, Liu ZY, Qin L, Zhao P.

    12/24/2016
    This study focused on the natriuretic peptide receptor C gene (NPR3). The correlation analysis between NPR3 and hypertension was replicated in 450 Chinese Dai and 484 Chinese Mongolian individuals.

    Correlation between natriuretic peptide receptor C (NPR3) gene polymorphisms and hypertension in the Dai people of China.
    Sun H, Yang ZQ, Liu SY, Yu L, Huang K, Lin KQ, Chu JY, Huang XQ.

    06/28/2016
    Angiotensin II downregulates vascular smooth muscle cell NPR-C gene expression by destabilizing its mRNA.

    Downregulation of natriuretic peptide clearance receptor mRNA in vascular smooth muscle cells by angiotensin II.
    Jiao Y, Yang Q.

    02/13/2016
    Results from this study point to a role for miR-100 in the regulation of NPR3 expression, and suggest a possible therapeutic target for modulation of NP bioactivity in heart disease.

    Natriuretic peptide receptor 3 (NPR3) is regulated by microRNA-100.
    Wong LL, Wee AS, Lim JY, Ng JY, Chong JP, Liew OW, Lilyanna S, Martinez EC, Ackers-Johnson MA, Vardy LA, Armugam A, Jeyaseelan K, Ng TP, Lam CS, Foo RS, Richards AM, Chen YT.

    01/16/2016
    Data show that natriuretic peptide receptor 3 (NPR3) single nucleotide polymorphism (SNP) is independently associated with diastolic dysfunction and does not appear to be related to alterations in circulating levels of natriuretic peptides.

    A functional genetic variant (N521D) in natriuretic peptide receptor 3 is associated with diastolic dysfunction: the prevalence of asymptomatic ventricular dysfunction study.
    Pereira NL, Redfield MM, Scott C, Tosakulwong N, Olson TM, Bailey KR, Rodeheffer RJ, Burnett JC Jr., Free PMC Article

    12/6/2014
    The significant change in NPR3 protein was observed for the Arg146 variant allozyme, with 20% of wild-type protein, primarily because of autophagy-dependent degradation.

    Natriuretic peptide receptor-3 gene (NPR3): nonsynonymous polymorphism results in significant reduction in protein expression because of accelerated degradation.
    Pereira NL, Lin D, Pelleymounter L, Moon I, Stilling G, Eckloff BW, Wieben ED, Redfield MM, Burnett JC Jr, Yee VC, Weinshilboum RM., Free PMC Article

    10/26/2013
    polymorphisms or haplotype in NPR3 gene may influence the risk of ischemic stroke or hypertension independently in Chinese population.

    Association of natriuretic peptide receptor-C gene with ischemic stroke and hypertension in Chinese Han population.
    Liu Y, Li S, Chen X, Zheng L, Yang Y, Jin L, Wang X.

    06/1/2013
    a NPR3 promoter gene variant could have a role on cerebrovascular disease susceptibility

    Association of a single nucleotide polymorphism of the NPR3 gene promoter with early onset ischemic stroke in an Italian cohort.
    Rubattu S, Giusti B, Lotta LA, Peyvandi F, Cotugno M, Stanzione R, Marchitti S, Palombella AM, Di Castro S, Rasura M, Mannucci PM, Volpe M.

    06/1/2013
    Report the presence of CNP and its receptors, NPR2/3 in atherosclerotic plaques of human carotid artery, with increased expression of NPR3 in histologically unstable plaques.

    C-type natriuretic peptide and its receptors in atherosclerotic plaques of the carotid artery of clinically asymptomatic patients.
    Kuehnl A, Pelisek J, Pongratz J, Eckstein HH.

    07/28/2012
    Results demonstrate the opposite effects of NPR-A and NPR-C in LPS-mediated endothelial permeability and lung injury.

    Opposite effects of ANP receptors in attenuation of LPS-induced endothelial permeability and lung injury.
    Xing J, Yakubov B, Poroyko V, Birukova AA., Free PMC Article

    06/9/2012
    Data found a consistent and significant association between the rs2270915 polymorphism of the NPR3 gene and SBP in diabetic patients. This genetic variation may affect pressure response to changes in dietary sodium.

    Impact of natriuretic peptide clearance receptor (NPR3) gene variants on blood pressure in type 2 diabetes.
    Saulnier PJ, Roussel R, Halimi JM, Lebrec J, Dardari D, Maimaitiming S, Guilloteau G, Prugnard X, Marechaud R, Ragot S, Marre M, Hadjadj S, SURDIAGENE, DIAB2NEPHROGENE, and DIABHYCAR study groups.., Free PMC Article

    08/27/2011
    integrative genomics approach to a large cohort of medulloblastomas has identified four disparate subgroups (NPR3)with distinct demographics, clinical presentation, transcriptional profiles, genetic abnormalities, and clinical outcome.

    Medulloblastoma comprises four distinct molecular variants.
    Northcott PA, Korshunov A, Witt H, Hielscher T, Eberhart CG, Mack S, Bouffet E, Clifford SC, Hawkins CE, French P, Rutka JT, Pfister S, Taylor MD., Free PMC Article

    07/2/2011
    The mRNA levels of natriuretic peptide receptor-C appear to be increased in epicardial adipose tissue independent of their plasma levels in coronary artery disease.

    Greater expression of inflammatory cytokines, adrenomedullin, and natriuretic peptide receptor-C in epicardial adipose tissue in coronary artery disease.
    Shibasaki I, Nishikimi T, Mochizuki Y, Yamada Y, Yoshitatsu M, Inoue Y, Kuwata T, Ogawa H, Tsuchiya G, Ishimitsu T, Fukuda H.

    04/16/2011
    Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

    Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators.., Free PMC Article

    03/1/2011
    The data indicates that ANP, BNP, and CNP and natriuretic peptide receptor transcripts are expressed and are functional in human lens epithelial cells.

    Characterization and functional expression of the natriuretic peptide system in human lens epithelial cells.
    Cammarata PR, Braun B, Dimitrijevich SD, Pack J., Free PMC Article

    11/13/2010
    Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

    Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article

    06/30/2010
    results suggest that variation in the C-type natriuretic peptide signaling pathway, involving the NPPC and NPR3 genes, plays an important role in determining human body height.

    A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation.
    Estrada K, Krawczak M, Schreiber S, van Duijn K, Stolk L, van Meurs JB, Liu F, Penninx BW, Smit JH, Vogelzangs N, Hottenga JJ, Willemsen G, de Geus EJ, Lorentzon M, von Eller-Eberstein H, Lips P, Schoor N, Pop V, de Keijzer J, Hofman A, Aulchenko YS, Oostra BA, Ohlsson C, Boomsma DI, Uitterlinden AG, van Duijn CM, Rivadeneira F, Kayser M., Free PMC Article

    01/21/2010
    Data indicate that the familial ANP mutation associated with atrial fibrillation has only minor effects on natriuretic peptide receptor interactions but markedly modifies peptide proteolysis.

    A familial mutation renders atrial natriuretic Peptide resistant to proteolytic degradation.
    Dickey DM, Yoder AR, Potter LR., Free PMC Article

    01/21/2010
    the NPR-C receptor is expressed in normal and neoplastic human alpha cells.

    C-type natriuretic peptide receptor expression in pancreatic alpha cells.
    Burgess MD, Moore KD, Carter GM, Alli AA, Granda CS, Ichii H, Ricordi C, Gower WR Jr.

    01/21/2010
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