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    NHLH2 nescient helix-loop-helix 2 [ Homo sapiens (human) ]

    Gene ID: 4808, updated on 3-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    In Silico Examination of Single Nucleotide Missense Mutations in NHLH2, a Gene Linked to Infertility and Obesity.

    In Silico Examination of Single Nucleotide Missense Mutations in NHLH2, a Gene Linked to Infertility and Obesity.
    Madsen AT, Good DJ., Free PMC Article

    03/1/2023
    Inactivating NHLH2 variants cause idiopathic hypogonadotropic hypogonadism and obesity in humans.

    Inactivating NHLH2 variants cause idiopathic hypogonadotropic hypogonadism and obesity in humans.
    Topaloglu AK, Simsek E, Kocher MA, Mammadova J, Bober E, Kotan LD, Turan I, Celiloglu C, Gurbuz F, Yuksel B, Good DJ.

    02/5/2022
    Natural Selection at the NHLH2 Core Promoter Exceptionally Long CA-Repeat in Human and Disease-Only Genotypes in Late-Onset Neurocognitive Disorder.

    Natural Selection at the NHLH2 Core Promoter Exceptionally Long CA-Repeat in Human and Disease-Only Genotypes in Late-Onset Neurocognitive Disorder.
    Afshar H, Adelirad F, Kowsari A, Kalhor N, Delbari A, Najafipour R, Foroughan M, Bozorgmehr A, Khamse S, Nazaripanah N, Ohadi M.

    10/9/2021
    These data support part of our hypothesis that NHLH2 or MAO-A polymorphism is associated with sedentary behavior.

    A Genetic Basis for Motivated Exercise.
    Good DJ, Li M, Deater-Deckard K.

    06/11/2016
    Leptin signaling regulates hypothalamic expression of Nhlh2 through Stat3.

    Leptin signaling regulates hypothalamic expression of nescient helix-loop-helix 2 (Nhlh2) through signal transducer and activator 3 (Stat3).
    Al Rayyan N, Zhang J, Burnside AS, Good DJ., Free PMC Article

    11/8/2014
    Two single nucleotide polymorphisms in the human nescient helix-loop-helix 2 (NHLH2) gene reduce mRNA stability or reduce helical structure in the DNA binding domain of the protein.

    Two single nucleotide polymorphisms in the human nescient helix-loop-helix 2 (NHLH2) gene reduce mRNA stability and DNA binding.
    Al Rayyan N, Wankhade UD, Bush K, Good DJ., Free PMC Article

    01/26/2013
    The present results suggest that a transcriptional complex of LMO3 and HEN2 may contribute to the genesis and malignant phenotype of neuroblastoma by inhibiting HES1 which suppresses the transactivation of Mash1.

    Oncogenic LMO3 collaborates with HEN2 to enhance neuroblastoma cell growth through transactivation of Mash1.
    Isogai E, Ohira M, Ozaki T, Oba S, Nakamura Y, Nakagawara A., Free PMC Article

    10/29/2011
    Observational study of gene-disease association. (HuGE Navigator)

    Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.
    Raychaudhuri S, Thomson BP, Remmers EF, Eyre S, Hinks A, Guiducci C, Catanese JJ, Xie G, Stahl EA, Chen R, Alfredsson L, Amos CI, Ardlie KG, BIRAC Consortium, Barton A, Bowes J, Burtt NP, Chang M, Coblyn J, Costenbader KH, Criswell LA, Crusius JB, Cui J, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner DL, Ke X, Kurreeman FA, Lee AT, Liu X, Li Y, Martin P, Morgan AW, Padyukov L, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma IE, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth P, YEAR Consortium, Altshuler D, Karlson EW, Toes RE, de Vries N, Begovich AB, Siminovitch KA, Worthington J, Klareskog L, Gregersen PK, Daly MJ, Plenge RM., Free PMC Article

    12/2/2009
    proposes the novel hypothesis that transcriptional activity by Nhlh2 (NHLH2 in humans) controls either the ability or the motivation for exercise [review]

    Nhlh2: a basic helix-loop-helix transcription factor controlling physical activity.
    Good DJ, Coyle CA, Fox DL., Free PMC Article

    01/21/2010
    The deregulated expression of neuronal-specific LMO3 and HEN2 contributes to the genesis and progression of human neuroblastoma in a lineage-specific manner.

    LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma.
    Aoyama M, Ozaki T, Inuzuka H, Tomotsune D, Hirato J, Okamoto Y, Tokita H, Ohira M, Nakagawara A.

    01/21/2010
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