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    NEUROD2 neuronal differentiation 2 [ Homo sapiens (human) ]

    Gene ID: 4761, updated on 17-Jun-2019

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Study identifies a novel role of NeuroD2 as a tumor suppressor and prognostic biomarker in GBM the levels of which are tightly regulated by p53 and miR-210.

    p53 and miR-210 regulated NeuroD2, a neuronal basic helix-loop-helix transcription factor, is downregulated in glioblastoma patients and functions as a tumor suppressor under hypoxic microenvironment.
    Agrawal R, Garg A, Benny Malgulwar P, Sharma V, Sarkar C, Kulshreshtha R.

    01/12/2019
    Our findings suggest that the NEUROD2 gene could play a role in the pathophysiology of neurocognitive dysfunctions as well as in the change of cognitive symptoms under antipsychotic treatment in schizophrenia and schizoaffective disorder.

    Associations of NEUROD2 polymorphisms and change of cognitive dysfunctions in schizophrenia and schizoaffective disorder after eight weeks of antipsychotic treatment.
    Spellmann I, Riedel M, Städtler J, Zill P, Obermeier M, Cerovecki A, Dehning S, Schennach R, Epple M, Opgen-Rhein M, Müller N, Bondy B, Möller HJ, Musil R.

    02/10/2018
    Downregulation of NEUROD2 is associated with neurodevelopmental defects in trisomies 18.

    Novel neurodevelopmental information revealed in amniotic fluid supernatant transcripts from fetuses with trisomies 18 and 21.
    Hui L, Slonim DK, Wick HC, Johnson KL, Koide K, Bianchi DW., Free PMC Article

    01/12/2013
    The results of this study did not provide evidence for an involvement of NEUROD2 polymorphisms in the pathophysiology of alcohol dependence.

    Lack of association between SNPs in the NEUROD2 gene and alcohol dependence in a German patient sample.
    Zill P, Preuss UW, Koller G, Bondy B, Soyka M, Zill P, Preuss UW, Koller G, Bondy B, Soyka M.

    06/4/2011
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (5) articles

    Lack of association between SNPs in the NEUROD2 gene and alcohol dependence in a German patient sample.
    Zill P, Preuss UW, Koller G, Bondy B, Soyka M, Zill P, Preuss UW, Koller G, Bondy B, Soyka M.

    Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.
    Mavaddat N, Dunning AM, Ponder BA, Easton DF, Pharoah PD.

    Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.
    Gratacòs M, Costas J, de Cid R, Bayés M, González JR, Baca-García E, de Diego Y, Fernández-Aranda F, Fernández-Piqueras J, Guitart M, Martín-Santos R, Martorell L, Menchón JM, Roca M, Sáiz-Ruiz J, Sanjuán J, Torrens M, Urretavizcaya M, Valero J, Vilella E, Estivill X, Carracedo A, Psychiatric Genetics Network Group..

    HapMap-based study of the 17q21 ERBB2 amplicon in susceptibility to breast cancer.
    Benusiglio PR, Pharoah PD, Smith PL, Lesueur F, Conroy D, Luben RN, Dew G, Jordan C, Dunning A, Easton DF, Ponder BA.

    NeuroD/beta2 gene G-->A polymorphism may affect onset pattern of type 1 diabetes in Japanese.
    Yamada S, Motohashi Y, Yanagawa T, Maruyama T, Kasuga A, Hirose H, Matsubara K, Shimada A, Saruta T.

    03/13/2008
    Lower neuroD2 mRNA levels was found in opiate-dependent individuals in the cortex and hippocampus.

    A possible impact of the neuroD2 transcription factor on the development of drug abusing behavior.
    Zill P, Büttner A, Eisenmenger W, Bondy B.

    01/21/2010
    expression during trophoblast invasion

    The proneural genes NEUROD1 and NEUROD2 are expressed during human trophoblast invasion.
    Westerman BA, Poutsma A, Maruyama K, Schrijnemakers HF, van Wijk IJ, Oudejans CB.

    01/21/2010
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