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    MIR373 microRNA 373 [ Homo sapiens (human) ]

    Gene ID: 442918, updated on 26-Aug-2018

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    MiRNA373 transfection suppressed SiHa cell growth and proliferation. MiRNA373 induced SiHa cell apoptosis possibly through downregulating IAPs.

    MiRNA373 induces cervical squamous cell carcinoma SiHa cell apoptosis.
    Fan L, Liu Z, Zhang Y, Zhu H, Yu H, Yang F, Yang R, Wu F.

    08/25/2018
    miR-373 suppresses gastric cancer metastasis by downregulating vimentin.

    miR-373 suppresses gastric cancer metastasis by downregulating vimentin.
    Shi Y, Shi H, Zhang B, Yan Y, Han X, Jiang W, Qian H, Xu W.

    08/18/2018
    this study demonstrated for the first time that miR-373 is frequently up-regulated during HSV-1 infection and promotes HSV-1 replication by down-regulating IRF1 to negatively regulate Type I IFN response

    MicroRNA-373 facilitates HSV-1 replication through suppression of type I IFN response by targeting IRF1.
    Xie Y, He S, Wang J.

    08/11/2018
    Data suggest that circulating levels and expression levels of specific microRNAs are altered in women with breast cancer; serum levels and expression levels in breast tissue of MIRN222, MIRN21, and MIRN373 are up-regulated in breast cancer patients as compared to control subjects (women with benign breast disease or healthy women).

    Potential diagnostic role of circulating MiRNAs in breast cancer: Implications on clinicopathological characters.
    Swellam M, El Magdoub HM, Hassan NM, Hefny MM, Sobeih ME.

    07/21/2018
    Upregulated miR-373 levels and simultaneously downregulated levels of CD44 and E-cadherin were noted in this study.

    Expression of miR-373 and its predicted target genes E-cadherin and CD44 in patients with laryngeal squamous cell carcinoma.
    Timirci-Kahraman Ö, Verim A, Farooqi AA, Turan S, Özkan-Küçük NE, Yaylim İ.

    07/21/2018
    Knockdown of miR373 exerted a significant suppressive effect on RCC proliferation and colony formation in vitro, and tumor growth in a xenograft nude mouse model.

    MicroRNA‑373 promotes tumorigenesis of renal cell carcinoma in vitro and in vivo.
    Li Y, Zhang D, Wang J.

    06/9/2018
    Data suggest that serum miR-373 might serve as a promising biomarker for the early detection and prognosis prediction of pancreatic cancer (PC).

    Low serum miR-373 predicts poor prognosis in patients with pancreatic cancer.
    Hua Y, Chen H, Wang L, Wang F, Wang P, Ning Z, Li Y, Liu L, Chen Z, Meng Z.

    04/28/2018
    MiR-373 promotes growth and cellular invasion in osteosarcoma cells by activating the PI3K/AKT-Rac1-JNK pathway.

    MicroRNA-373 Promotes Growth and Cellular Invasion in Osteosarcoma Cells by Activation of the PI3K/AKT-Rac1-JNK Pathway: The Potential Role in Spinal Osteosarcoma.
    Liu Y, Cheng Z, Pan F, Yan W.

    03/31/2018
    MiR-373 was a tumor suppressor and downregulated the expression of VE-cadherin, the expression and activity of MMP-2, and MMP-9.

    Long Non-Coding RNA HOXA-AS2 Regulates Malignant Glioma Behaviors and Vasculogenic Mimicry Formation via the MiR-373/EGFR Axis.
    Gao Y, Yu H, Liu Y, Liu X, Zheng J, Ma J, Gong W, Chen J, Zhao L, Tian Y, Xue Y.

    03/17/2018
    Our data suggest an important role of beta2-AR/STAT3/miR-373 signaling on the transformation of gastric cancer cells.

    Isoproterenol regulates CD44 expression in gastric cancer cells through STAT3/MicroRNA373 cascade.
    Wei B, Sun X, Geng Z, Shi M, Chen Z, Chen L, Wang Y, Fu X.

    12/9/2017
    The serum concentrations of cell-free microRNAs miR-373, miR-200a, miR-200b and miR-200c were significantly higher in epithelial ovarian cancer (EOC) patients.

    Circulating Cell-Free miR-373, miR-200a, miR-200b and miR-200c in Patients with Epithelial Ovarian Cancer.
    Meng X, Müller V, Milde-Langosch K, Trillsch F, Pantel K, Schwarzenbach H.

    09/23/2017
    First evidence that miR-205 and miR-373 may differentially contribute to the aggressive phenotype of Mucinous adenocarcinoma in colorectal cancer.

    MiR-205 and MiR-373 Are Associated with Aggressive Human Mucinous Colorectal Cancer.
    Eyking A, Reis H, Frank M, Gerken G, Schmid KW, Cario E., Free PMC Article

    08/12/2017
    Down-regulation of TRPS1 by miR-373, acting as a transcriptional activator, promotes epithelial-mesenchymal transition (EMT) and metastasis by repressing FOXA1 transcription, expanding upon its previously reported role as a transcription repressor.

    Down-regulation of TRPS1 stimulates epithelial-mesenchymal transition and metastasis through repression of FOXA1.
    Huang JZ, Chen M, Zeng M, Xu SH, Zou FY, Chen D, Yan GR.

    06/3/2017
    our findings reveal a new regulatory mechanism for miR-373-3p and suggest that miR-373-3p might be a potential target in tongue squamous cell carcinoma therapy

    miR-373-3p Targets DKK1 to Promote EMT-Induced Metastasis via the Wnt/<b>β</b>-Catenin Pathway in Tongue Squamous Cell Carcinoma.
    Weng J, Zhang H, Wang C, Liang J, Chen G, Li W, Tang H, Hou J., Free PMC Article

    04/29/2017
    the HOTAIR lncRNA positively regulated the protein expression of Rab22a through competition for miR-373 binding. the positive regulation between HOTAIR and Rab22a may be partially attributed to the ceRNA regulatory network via miR-373, indicating a potential therapeutic target for ovarian cancer.

    LncRNA HOTAIR controls the expression of Rab22a by sponging miR-373 in ovarian cancer.
    Zhang Z, Cheng J, Wu Y, Qiu J, Sun Y, Tong X., Free PMC Article

    04/8/2017
    CD44 and TGFBR2 are the functional targets of miR-373, which are responsible for the tumor suppressive functions of miR-373

    miR-373 Inhibits Glioma Cell U251 Migration and Invasion by Down-Regulating CD44 and TGFBR2.
    Wei F, Wang Q, Su Q, Huang H, Luan J, Xu X, Wang J.

    02/25/2017
    The results show that miR-370 and miR-373 contribute to the pathogenesis of osteoarthritis (OA) and act as negative regulators of SHMT-2 and MECP-2, respectively.

    miR-370 and miR-373 regulate the pathogenesis of osteoarthritis by modulating one-carbon metabolism via SHMT-2 and MECP-2, respectively.
    Song J, Kim D, Chun CH, Jin EJ., Free PMC Article

    09/24/2016
    Activation of the miR-373-TXNIP-HIF1alpha-TWIST signaling axis is correlated with a worse outcome in patients with breast cancer.

    MiR-373 drives the epithelial-to-mesenchymal transition and metastasis via the miR-373-TXNIP-HIF1α-TWIST signaling axis in breast cancer.
    Chen D, Dang BL, Huang JZ, Chen M, Wu D, Xu ML, Li R, Yan GR., Free PMC Article

    08/13/2016
    A serum/CSF miRNA panel (miR-371a-3p, miR-372-3p, miR-373-3p and miR-367-3p) was sensitive and specific for diagnosing pediatric extracranial malignant GCT as well as detecting relapse, and distinguishing GCT vs. non-GCT intracranial neoplasms.

    A pipeline to quantify serum and cerebrospinal fluid microRNAs for diagnosis and detection of relapse in paediatric malignant germ-cell tumours.
    Murray MJ, Bell E, Raby KL, Rijlaarsdam MA, Gillis AJ, Looijenga LH, Brown H, Destenaves B, Nicholson JC, Coleman N., Free PMC Article

    06/11/2016
    Epigenetic silencing of ITGA2 by MiR-373 promotes cell migration in breast cancer.

    Epigenetic silencing of ITGA2 by MiR-373 promotes cell migration in breast cancer.
    Ding W, Fan XL, Xu X, Huang JZ, Xu SH, Geng Q, Li R, Chen D, Yan GR., Free PMC Article

    05/14/2016
    Data suggest that microRNAs miR-10b, 21, 200c, 373 and 520c may control both metastasis and stemness potential.

    Evaluation of the expressions pattern of miR-10b, 21, 200c, 373 and 520c to find the correlation between epithelial-to-mesenchymal transition and melanoma stem cell potential in isolated cancer stem cells.
    Fomeshi MR, Ebrahimi M, Mowla SJ, Khosravani P, Firouzi J, Khayatzadeh H.

    04/30/2016
    analysis of the functions of miR-373 and its implication in cancers [review]

    Diverse functions of miR-373 in cancer.
    Wei F, Cao C, Xu X, Wang J., Free PMC Article

    04/16/2016
    Low MIR373 expression is associated with cell cycle arrest in unrestricted somatic stem cells.

    MiR-371-373 cluster acts as a tumor-suppressor-miR and promotes cell cycle arrest in unrestricted somatic stem cells.
    Langroudi L, Jamshidi-Adegani F, Shafiee A, Rad SM, Keramati F, Azadmanesh K, Arefian E, Soleimani M.

    01/30/2016
    MiR-373-3p participated in the invasion and metastasis of lung adenocarcinoma cells, partly by upregulation of MMP-9 and MMP-14.

    [MiR-373-3p Promotes Invasion and Metastasis of Lung Adenocarcinoma Cells].
    Wu A, Li J, Wu K, Mo Y, Luo Y, Ye H, Shen X, Li S, Liang Y, Liu M, Yang Z., Free PMC Article

    01/30/2016
    these results demonstrate that miR-373 suppresses epithelial ovarian cancer invasion and metastasis by directly targeting Rab22a gene

    MiR-373 targeting of the Rab22a oncogene suppresses tumor invasion and metastasis in ovarian cancer.
    Zhang Y, Zhao FJ, Chen LL, Wang LQ, Nephew KP, Wu YL, Zhang S., Free PMC Article

    10/3/2015
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