| Characterizing ATP processing by the AAA+ protein p97 at the atomic level. | Characterizing ATP processing by the AAA+ protein p97 at the atomic level.
Shein M, Hitzenberger M, Cheng TC, Rout SR, Leitl KD, Sato Y, Zacharias M, Sakata E, Schütz AK., Free PMC Article | 03/7/2024 |
| The E2F1/MELTF axis fosters the progression of lung adenocarcinoma by regulating the Notch signaling pathway. | The E2F1/MELTF axis fosters the progression of lung adenocarcinoma by regulating the Notch signaling pathway.
Zhang L, Shi L. | 11/18/2023 |
| MELTF Might Regulate Ferroptosis, Pyroptosis, and Autophagy in Platelet-Rich Plasma-Mediated Endometrial Epithelium Regeneration. | MELTF Might Regulate Ferroptosis, Pyroptosis, and Autophagy in Platelet-Rich Plasma-Mediated Endometrial Epithelium Regeneration.
Mao Y, Wang M, Xiong Y, Wen X, Zhang M, Ma L, Zhang Y. | 05/10/2023 |
| The Role of Melanotransferrin (CD228) in the regulation of the differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells (hBM-MSC). | The Role of Melanotransferrin (CD228) in the regulation of the differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells (hBM-MSC).
Dubon M, Lee S, Park JH, Lee JY, Kang D., Free PMC Article | 11/6/2021 |
| The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke. | The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke.
Valsecchi V, Laudati G, Cuomo O, Sirabella R, Del Prete A, Annunziato L, Pignataro G., Free PMC Article | 10/9/2021 |
| High MELTF mRNA expression was associated with Gastric Cancer. | Level of Melanotransferrin in Tissue and Sera Serves as a Prognostic Marker of Gastric Cancer.
Sawaki K, Kanda M, Umeda S, Miwa T, Tanaka C, Kobayashi D, Hayashi M, Yamada S, Nakayama G, Omae K, Koike M, Kodera Y. | 11/30/2019 |
| Melanotransferrin is a serological marker of colorectal cancer by secretome analysis and quantitative proteomics. | Discovery of melanotransferrin as a serological marker of colorectal cancer by secretome analysis and quantitative proteomics.
Shin J, Kim HJ, Kim G, Song M, Woo SJ, Lee ST, Kim H, Lee C. | 07/25/2015 |
| PC3 tumors are sustained by a small number of tumor-initiating cells with stem-like characteristics, including strong self-renewal and pro-angiogenic capability and marked by the expression pattern FAM65Bhigh/MFI2low/LEF1low. | PC3 prostate tumor-initiating cells with molecular profile FAM65Bhigh/MFI2low/LEF1low increase tumor angiogenesis.
Zhang K, Waxman DJ., Free PMC Article | 03/26/2011 |
| Biochemical and spectroscopic studies of MTF1 are reported. | Biochemical and spectroscopic studies of human melanotransferrin (MTf): electron-paramagnetic resonance evidence for a difference between the iron-binding site of MTf and other transferrins.
Farnaud S, Amini M, Rapisarda C, Cammack R, Bui T, Drake A, Evans RW, Suryo Rahmanto Y, Richardson DR. | 01/21/2010 |
| Novel molecular targets directly or indirectly regulated by MTf and the potential pathways involved in its function, including modulation of proliferation. | Identification of distinct changes in gene expression after modulation of melanoma tumor antigen p97 (melanotransferrin) in multiple models in vitro and in vivo.
Suryo Rahmanto Y, Dunn LL, Richardson DR. | 01/21/2010 |
| this review discusses the studies that have demonstrated that melanotransferrin is not involved in iron metabolism, but plays a vital role in melanoma cell proliferation and tumorigenesis. | The melanoma tumor antigen, melanotransferrin (p97): a 25-year hallmark--from iron metabolism to tumorigenesis.
Suryo Rahmanto Y, Dunn LL, Richardson DR. | 01/21/2010 |
| HMB-45 (melanoma-associated antigen p97) and Melan-A combined were positive in 100% of the renal angiomyolipomas | Differential expression of melanocytic markers in myoid, lipomatous, and vascular components of renal angiomyolipomas.
Roma AA, Magi-Galluzzi C, Zhou M. | 01/21/2010 |
| results suggest a Plg-mediated internalization mechanism for the clearance of sMTf via annexin II and LRP | Plasminogen-dependent internalization of soluble melanotransferrin involves the low-density lipoprotein receptor-related protein and annexin II.
Michaud-Levesque J, Demeule M, Béliveau R. | 01/21/2010 |
| This melanoma-associated marker was detected in melanoma cell lines. | Detection of multiple melanoma-associated markers in melanoma cell lines by RT in situ PCR.
Guo J, Wen DR, Huang RR, Paul E, Wünsch P, Itakura E, Cochran AJ. | 01/21/2010 |
| Anti-angiogenic properties of soluble melanotransferrin may result from local overstimulation of plasminogen activation by tissue plasminogen activator, thus leading to subsequent degradation of the fibronectin matrix and endothelial cell detachment. | Melanotransferrin stimulates t-PA-dependent activation of plasminogen in endothelial cells leading to cell detachment.
Rolland Y, Demeule M, Béliveau R. | 01/21/2010 |
| Serum melanotransferrin exists in various conformations depending on the binding of bivalent cations or following post-translational modification; serum melanotransferrin levels are unchanged in subjects with Alzheimer's disease. | Expression of melanotransferrin isoforms in human serum: relevance to Alzheimer's disease.
Desrosiers RR, Bertrand Y, Nguyen QT, Demeule M, Gabathuler R, Kennard ML, Gauthier S, Béliveau R., Free PMC Article | 01/21/2010 |
| its ability to donate 59Fe to SK-Mel-28 melanoma cells and other cell types | The soluble form of the membrane-bound transferrin homologue, melanotransferrin, inefficiently donates iron to cells via nonspecific internalization and degradation of the protein.
Food MR, Sekyere EO, Richardson DR. | 01/21/2010 |
| The distribution of MTf and its splice variants may provide clues to their possible biological roles in melanoma and other tumors. | Examination of the distribution of the transferrin homologue, melanotransferrin (tumour antigen p97), in mouse and human.
Sekyere EO, Dunn LL, Richardson DR. | 01/21/2010 |
| melanotransferrin has a role in cell proliferation and tumorigenesis | The function of melanotransferrin: a role in melanoma cell proliferation and tumorigenesis.
Dunn LL, Sekyere EO, Suryo Rahmanto Y, Richardson DR. | 01/21/2010 |
| membrane-bound and soluble p97 affect the migration capacity of endothelial and melanoma cells and suggest that p97 could be involved in the regulation of plasminogen activation by interacting with pro-uPA and plasminogen. | Regulation of plasminogen activation: a role for melanotransferrin (p97) in cell migration.
Demeule M, Bertrand Y, Michaud-Levesque J, Jodoin J, Rolland Y, Gabathuler R, Béliveau R. | 01/21/2010 |
| The human genome contains a second melanotransferrin gene (MTf2). There are two isoforms of melanotransferrin. | A second melanotransferrin gene (MTf2) and a novel protein isoform: explanation for the membrane-bound and soluble forms of melanotransferrin?
Sekyere E, Food MR, Richardson DR. | 01/21/2010 |
| Altogether, these findings strongly suggest that MTf overexpression in melanoma cells contributes to tumor progression by stimulating plasmin generation as well as cell migration and invasion. | Melanotransferrin induces human melanoma SK-Mel-28 cell invasion in vivo.
Bertrand Y, Demeule M, Michaud-Levesque J, Béliveau R. | 01/21/2010 |