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    MAP1A microtubule associated protein 1A [ Homo sapiens (human) ]

    Gene ID: 4130, updated on 2-Oct-2018

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    MAP1A functions to maintain the neuronal microtubule network in the brain and mutations cause Purkinje cell degeneration.

    Mutations in the microtubule-associated protein 1A (Map1a) gene cause Purkinje cell degeneration.
    Liu Y, Lee JW, Ackerman SL., Free PMC Article

    results support a role for MAP1 proteins in promoting efficient retrograde trafficking of HIV-1 by stimulating the formation of stable microtubules and mediating the association of HIV-1 cores with microtubules.

    Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus.
    Fernandez J, Portilho DM, Danckaert A, Munier S, Becker A, Roux P, Zambo A, Shorte S, Jacob Y, Vidalain PO, Charneau P, Clavel F, Arhel NJ., Free PMC Article

    This protein has been found differentially expressed in thalami from patients with schizophrenia.

    Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.
    Martins-de-Souza D, Maccarrone G, Wobrock T, Zerr I, Gormanns P, Reckow S, Falkai P, Schmitt A, Turck CW.

    Observational study of gene-disease association. (HuGE Navigator)

    Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses.
    Tomppo L, Hennah W, Lahermo P, Loukola A, Tuulio-Henriksson A, Suvisaari J, Partonen T, Ekelund J, Lönnqvist J, Peltonen L., Free PMC Article

    Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.

    Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
    Martins-de-Souza D, Gattaz WF, Schmitt A, Rewerts C, Maccarrone G, Dias-Neto E, Turck CW.

    postulate that the RhoB and MAP1A/LC2 interactions facilitate endocytic vesicle trafficking and regulate the trafficking of signaling molecules

    MAP1A light chain-2 interacts with GTP-RhoB to control epidermal growth factor (EGF)-dependent EGF receptor signaling.
    Lajoie-Mazenc I, Tovar D, Penary M, Lortal B, Allart S, Favard C, Brihoum M, Pradines A, Favre G.

    MAP1A LC2 is a biological enhancer of EPAC1 activity toward Rap1 and associated downstream signaling mechanisms

    MAP1A light chain 2 interacts with exchange protein activated by cyclic AMP 1 (EPAC1) to enhance Rap1 GTPase activity and cell adhesion.
    Gupta M, Yarwood SJ.

    Complexes (MAP1B heavy chain-MAP1A light chain) form through interaction of homologous domains conserved in heavy and light chains of MAP1A and MAP1B. Conserved domains of the MAP1A and MAP1B light chains account for formation of light chain heterodimers.

    Heterotypic complex formation between subunits of microtubule-associated proteins 1A and 1B is due to interaction of conserved domains.
    Noiges R, Stroissnigg H, Tranciková A, Kalny I, Eichinger R, Propst F.

    Data show that two regulatory factor for X box (RFX1 and 3) binding sites in exon1 of both the mouse and human microtubule-associated protein (MAP1A) gene are important for effective transcriptional repression in non-neuronal cells.

    Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter.
    Nakayama A, Murakami H, Maeyama N, Yamashiro N, Sakakibara A, Mori N, Takahashi M.

    a novel protein-binding partner for EPAC1 and EPAC2, light chain 2 of MAP1A (microtubule-associated protein 1A)

    Exchange protein directly activated by cAMP (EPAC) interacts with the light chain (LC) 2 of MAP1A.
    Magiera MM, Gupta M, Rundell CJ, Satish N, Ernens I, Yarwood SJ., Free PMC Article

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