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    AQP7 aquaporin 7 [ Homo sapiens (human) ]

    Gene ID: 364, updated on 5-Mar-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Aquaporin-7-Mediated Glycerol Permeability Is Linked to Human Sperm Motility in Asthenozoospermia and during Sperm Capacitation.

    Aquaporin-7-Mediated Glycerol Permeability Is Linked to Human Sperm Motility in Asthenozoospermia and during Sperm Capacitation.
    Ribeiro JC, Bernardino RL, Gonçalves A, Barros A, Calamita G, Alves MG, Oliveira PF., Free PMC Article

    08/14/2023
    Cryo-EM structure supports a role of AQP7 as a junction protein.

    Cryo-EM structure supports a role of AQP7 as a junction protein.
    Huang P, Venskutonytė R, Prasad RB, Ardalani H, de Maré SW, Fan X, Li P, Spégel P, Yan N, Gourdon P, Artner I, Lindkvist-Petersson K., Free PMC Article

    02/13/2023
    Cholecystokinin promotes functional expression of the aquaglycerol channel aquaporin 7 in adipocytes.

    Cholecystokinin promotes functional expression of the aquaglycerol channel aquaporin 7 in adipocytes.
    Plaza A, Merino B, Ruiz-Gayo M.

    07/23/2022
    [Association study of single nucleotide polymorphisms of AQP7 and AQP9 genes with type 2 diabetes mellitus among ethnic Han Chinese population].

    [Association study of single nucleotide polymorphisms of AQP7 and AQP9 genes with type 2 diabetes mellitus among ethnic Han Chinese population].
    He S, Yang M, Yang Y, Wang F, Wang X, Lu T, Jiao M, Li Y.

    01/29/2022
    Aquaglyceroporins and orthodox aquaporins in human adipocytes.

    Aquaglyceroporins and orthodox aquaporins in human adipocytes.
    Huang P, Hansen JS, Saba KH, Bergman A, Negoita F, Gourdon P, Hagström-Andersson A, Lindkvist-Petersson K.

    01/1/2022
    Association of Aquaporin-3, Aquaporin-7, NOS3 and CYBA polymorphisms with hypertensive disorders in women.

    Association of Aquaporin-3, Aquaporin-7, NOS3 and CYBA polymorphisms with hypertensive disorders in women.
    da Silva IV, Santos AC, Matos A, Pereira da Silva A, Soveral G, Rebelo I, Bicho M.

    11/13/2021
    AQP7 mediates post-menopausal lipogenesis in adipocytes through FSH-induced transcriptional crosstalk with AP-1 sites.

    AQP7 mediates post-menopausal lipogenesis in adipocytes through FSH-induced transcriptional crosstalk with AP-1 sites.
    Chen L, Chen H, Liu X, Li J, Gao Q, Shi S, Wang T, Ye X, Lu Y, Zhang D, Sheng J, Jin L, Huang H.

    11/13/2021
    Different expression and localization of aquaporin 7 and aquaporin 9 in granulosa cells, oocytes, and embryos of patients with polycystic ovary syndrome and the negatively correlated relationship with insulin regulation.

    Different expression and localization of aquaporin 7 and aquaporin 9 in granulosa cells, oocytes, and embryos of patients with polycystic ovary syndrome and the negatively correlated relationship with insulin regulation.
    Song WY, Wang Y, Hou XM, Tian CC, Wu L, Ma XS, Jin HX, Yao GD, Sun YP.

    08/7/2021
    Structural Basis for Glycerol Efflux and Selectivity of Human Aquaporin 7.

    Structural Basis for Glycerol Efflux and Selectivity of Human Aquaporin 7.
    de Maré SW, Venskutonytė R, Eltschkner S, de Groot BL, Lindkvist-Petersson K.

    05/1/2021
    Glucocorticoid gene regulation of aquaporin-7.

    Glucocorticoid gene regulation of aquaporin-7.
    González-Dávalos L, Álvarez-Pérez M, Quesada-López T, Cereijo R, Campderrós L, Piña E, Shimada A, Villarroya F, Varela-Echavarria A, Mora O.

    04/3/2021
    Aquaporin-7 Regulates the Response to Cellular Stress in Breast Cancer.

    Aquaporin-7 Regulates the Response to Cellular Stress in Breast Cancer.
    Dai C, Charlestin V, Wang M, Walker ZT, Miranda-Vergara MC, Facchine BA, Wu J, Kaliney WJ, Dovichi NJ, Li J, Littlepage LE., Free PMC Article

    02/13/2021
    The metabolic implications of aquaporin 7 (AQP7) promoter variants in lean children and children with obesity.

    The metabolic implications of aquaporin 7 (AQP7) promoter variants in lean children and children with obesity.
    Oikonomou E, Kostopoulou E, Rojas-Gil AP, Georgiou G, Spiliotis BE.

    12/12/2020
    Identification of functional estrogen response elements in glycerol channel Aquaporin-7 gene.

    Identification of functional estrogen response elements in glycerol channel Aquaporin-7 gene.
    Xing L, Jin B, Fu X, Zhu J, Guo X, Xu W, Mou X, Wang Z, Jiang F, Zhou Y, Chen X, Shu J.

    09/5/2020
    NEAT1 played an important role in the activation of ERalpha to regulate AQP7-mediated hepatic steatosis

    Long non-coding RNA NEAT1 promotes steatosis via enhancement of estrogen receptor alpha-mediated AQP7 expression in HepG2 cells.
    Fu X, Zhu J, Zhang L, Shu J.

    08/31/2019
    adipose tissue lipolysis. However, in contrast to SAT AQP7, skeletal muscle AQP7 protein abundance is markedly increased in obese T2D men, potentially contributing to the excess lipid accumulation in skeletal muscle in type 2 diabetes

    Increased AQP7 abundance in skeletal muscle from obese men with type 2 diabetes.
    Lebeck J, Søndergaard E, Nielsen S.

    07/6/2019
    AQP7 messenger RNA (mRNA) was increased in the younger obese prepubertal children but decreased in the obese adolescents (p=0.014) who also had increased insulin and homeostatic model assessment - insulin resistance.

    Adipocyte aquaporin 7 (AQP7) expression in lean children and children with obesity. Possible involvement in molecular mechanisms of childhood obesity.
    Oikonomou E, Kostopoulou E, Rojas-Gil AP, Georgiou G, Spiliotis BE.

    01/26/2019
    ex vivo studies in human primary adipocytes, demonstrate that perilipin 1 binds to AQP7, and that catecholamine activated protein kinase A phosphorylates the N-terminus of AQP7, thereby reducing complex formation

    Perilipin 1 binds to aquaporin 7 in human adipocytes and controls its mobility via protein kinase A mediated phosphorylation.
    Hansen JS, Krintel C, Hernebring M, Haataja TJ, de Marè S, Wasserstrom S, Kosinska-Eriksson U, Palmgren M, Holm C, Stenkula KG, Jones HA, Lindkvist-Petersson K.

    05/20/2017
    Aquaporins AQP3, -7, -8, and -11 proteins were found in sperm cells and localized in the head (AQP7), in the middle piece (AQP8) and in the tail (AQP3 and -11) in both the plasma membrane and in intracellular structures.

    Aquaporin-Mediated Water and Hydrogen Peroxide Transport Is Involved in Normal Human Spermatozoa Functioning.
    Laforenza U, Pellavio G, Marchetti AL, Omes C, Todaro F, Gastaldi G., Free PMC Article

    04/22/2017
    AQP3 was upregulated, and AQP7 and AQP9 were downregulated in hepatocellular carcinoma. A high expression of AQP3 and low expression of AQP7 was significantly associated with the aggressive features of hepatocellular carcinoma.

    Expression and clinical significance of aquaglyceroporins in human hepatocellular carcinoma.
    Chen XF, Li CF, Lü L, Mei ZC.

    02/18/2017
    the human aquaglyceroporins, i.e., AQP3, AQP7, AQP9 and AQP10 can act as silicon transporters in both Xenopus laevis oocytes and HEK-293 cells.

    Aquaporins Mediate Silicon Transport in Humans.
    Garneau AP, Carpentier GA, Marcoux AA, Frenette-Cotton R, Simard CF, Rémus-Borel W, Caron L, Jacob-Wagner M, Noël M, Powell JJ, Bélanger R, Côté F, Isenring P., Free PMC Article

    05/14/2016
    a direct involvement of AQP7 in water and glycerol transport

    Biophysical assessment of human aquaporin-7 as a water and glycerol channel in 3T3-L1 adipocytes.
    Madeira A, Camps M, Zorzano A, Moura TF, Soveral G., Free PMC Article

    03/7/2015
    AQP7-specific glycerol transport was furthermore found to be specifically inhibited.

    Functional characteristics of aquaporin 7 as a facilitative glycerol carrier.
    Katano T, Ito Y, Ohta K, Yasujima T, Inoue K, Yuasa H.

    02/14/2015
    REVIEW: the current knowledge on the role of the glycerol channels AQP7 and AQP9 in controlling glycerol metabolism in adipose tissue and liver

    Metabolic impact of the glycerol channels AQP7 and AQP9 in adipose tissue and liver.
    Lebeck J.

    11/8/2014
    AQP7 overexpression may be related to insulin sensitivity and glucose homeostasis in women with the polycystic ovary syndrome.

    Aquaglyceroporin-7 overexpression in women with the polycystic ovary syndrome.
    Seow KM, Lin YH, Wang PH, Hwang JL, Ho LT, Juan CC.

    08/31/2013
    AQP7 is expressed in human and mouse oocytes and upregulated by cryoprotectants.

    Cryoprotectants up-regulate expression of mouse oocyte AQP7, which facilitates water diffusion during cryopreservation.
    Tan YJ, Xiong Y, Ding GL, Zhang D, Meng Y, Huang HF, Sheng JZ.

    06/29/2013
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