| Long Noncoding RNA MIAT Modulates Chronic Retinal Ischemia-Reperfusion Injury in Mice via the microRNA-203-3p/SNAI2 Axis. | Long Noncoding RNA MIAT Modulates Chronic Retinal Ischemia-Reperfusion Injury in Mice via the microRNA-203-3p/SNAI2 Axis.
Fu W, Gu H, Ye Y. | 11/30/2023 |
| LncRNA Miat knockdown protects against pirarubicin-induced cardiotoxicity by targeting miRNA-129-1-3p. | LncRNA Miat knockdown protects against pirarubicin-induced cardiotoxicity by targeting miRNA-129-1-3p.
Huang P, Zhang W, Ji J, Ma J, Cheng H, Qin M, Wei D, Ren L. | 10/11/2023 |
| LncRNA Miat promotes neuropathic pain through miR-362-3p/BAMBI signaling axis. | LncRNA Miat promotes neuropathic pain through miR-362-3p/BAMBI signaling axis.
Zhang W, Zhou L, Zhang C. | 10/15/2022 |
| Long non-coding RNA MIAT impairs neurological function in ischemic stroke via up-regulating microRNA-874-3p-targeted IL1B. | Long non-coding RNA MIAT impairs neurological function in ischemic stroke via up-regulating microRNA-874-3p-targeted IL1B.
Zhang S, Zhang Y, Wang N, Wang Y, Nie H, Zhang Y, Han H, Wang S, Liu W, Bo C. | 03/26/2022 |
| LncRNA MIAT impairs cardiac contractile function by acting on mitochondrial translocator protein TSPO in a mouse model of myocardial infarction. | LncRNA MIAT impairs cardiac contractile function by acting on mitochondrial translocator protein TSPO in a mouse model of myocardial infarction.
Bai X, Yang C, Jiao L, Diao H, Meng Z, Wang L, Cui H, Sun L, Zhang Y, Yang B., Free PMC Article | 03/26/2022 |
| Long non-coding RNA myocardial infarction-associated transcript promotes 1-Methyl-4-phenylpyridinium ion-induced neuronal inflammation and oxidative stress in Parkinson's disease through regulating microRNA-221-3p/ transforming growth factor /nuclear factor E2-related factor 2 axis. | Long non-coding RNA myocardial infarction-associated transcript promotes 1-Methyl-4-phenylpyridinium ion-induced neuronal inflammation and oxidative stress in Parkinson's disease through regulating microRNA-221-3p/ transforming growth factor /nuclear factor E2-related factor 2 axis.
Lang Y, Zhang H, Yu H, Li Y, Liu X, Li M., Free PMC Article | 02/26/2022 |
| Serum extracellular vesicles containing MIAT induces atrial fibrosis, inflammation and oxidative stress to promote atrial remodeling and atrial fibrillation via blockade of miR-485-5p-mediated CXCL10 inhibition. | Serum extracellular vesicles containing MIAT induces atrial fibrosis, inflammation and oxidative stress to promote atrial remodeling and atrial fibrillation via blockade of miR-485-5p-mediated CXCL10 inhibition.
Chen Y, Chen X, Li H, Li Y, Cheng D, Tang Y, Sang H., Free PMC Article | 02/19/2022 |
| Knockdown of long noncoding RNA MIAT attenuates cigarette smoke-induced airway remodeling by downregulating miR-29c-3p-HIF3A axis. | Knockdown of long noncoding RNA MIAT attenuates cigarette smoke-induced airway remodeling by downregulating miR-29c-3p-HIF3A axis.
Gu W, Wang L, Deng G, Gu X, Tang Z, Li S, Jin W, Yang J, Guo X, Li Q. | 02/12/2022 |
| LncRNA MIAT knockdown alleviates oxygen-glucose deprivationinduced cardiomyocyte injury by regulating JAK2/STAT3 pathway via miR-181a-5p. | LncRNA MIAT knockdown alleviates oxygen-glucose deprivation‑induced cardiomyocyte injury by regulating JAK2/STAT3 pathway via miR-181a-5p.
Tan JK, Ma XF, Wang GN, Jiang CR, Gong HQ, Liu H. | 01/15/2022 |
| Overexpressing microRNA-203 alleviates myocardial infarction via interacting with long non-coding RNA MIAT and mitochondrial coupling factor 6. | Overexpressing microRNA-203 alleviates myocardial infarction via interacting with long non-coding RNA MIAT and mitochondrial coupling factor 6.
Wang F, Yu R, Wen S, Yin J, Shi Y, Hu H, Yan S. | 12/4/2021 |
| LncRNA MIAT Promotes Allergic Inflammation and Symptoms by Targeting MiR-10b-5p in Allergic Rhinitis Mice. | LncRNA MIAT Promotes Allergic Inflammation and Symptoms by Targeting MiR-10b-5p in Allergic Rhinitis Mice.
Ma Z, Lian H, Lin X, Li Y. | 11/6/2021 |
| Ablation of lncRNA Miat attenuates pathological hypertrophy and heart failure. | Ablation of lncRNA Miat attenuates pathological hypertrophy and heart failure.
Yang L, Deng J, Ma W, Qiao A, Xu S, Yu Y, Boriboun C, Kang X, Han D, Ernst P, Zhou L, Shi J, Zhang E, Li TS, Qiu H, Nakagawa S, Blackshaw S, Zhang J, Qin G., Free PMC Article | 08/21/2021 |
| Silencing long non-coding RNA MIAT ameliorates myocardial dysfunction induced by myocardial infarction via MIAT/miR-10a-5p/EGR2 axis. | Silencing long non-coding RNA MIAT ameliorates myocardial dysfunction induced by myocardial infarction via MIAT/miR-10a-5p/EGR2 axis.
Cao X, Ma Q, Wang B, Qian Q, Liu N, Liu T, Dong X., Free PMC Article | 07/31/2021 |
| Ablation of lncRNA MIAT mitigates high glucose-stimulated inflammation and apoptosis of podocyte via miR-130a-3p/TLR4 signaling axis. | Ablation of lncRNA MIAT mitigates high glucose-stimulated inflammation and apoptosis of podocyte via miR-130a-3p/TLR4 signaling axis.
Zhang M, Zhao S, Xu C, Shen Y, Huang J, Shen S, Li Y, Chen X. | 03/20/2021 |
| LncRNA MIAT Promotes Inflammation and Oxidative Stress in Sepsis-Induced Cardiac Injury by Targeting miR-330-5p/TRAF6/NF-kappaB Axis. | LncRNA MIAT Promotes Inflammation and Oxidative Stress in Sepsis-Induced Cardiac Injury by Targeting miR-330-5p/TRAF6/NF-κB Axis.
Xing PC, An P, Hu GY, Wang DL, Zhou MJ. | 02/6/2021 |
| MIAT could elevate the expression of SIRT1/PGC-1alpha via downregulating miR-29b. And the downregulated SIRT/PGC-1alpha increased the incidence of age-related hearing loss via promoting the apoptosis of cochlear hair cells. | Rs1894720 polymorphism in MIAT increased susceptibility to age-related hearing loss by modulating the activation of miR-29b/SIRT1/PGC-1α signaling.
Hao S, Wang L, Zhao K, Zhu X, Ye F. | 07/25/2020 |
| MIAT was consistently increased in serum and macrophages of necrotic cores in an advanced atherosclerosis mouse model. These data also demonstrated how MIAT inhibited efferocytosis by targeting miR-149-5p/CD47 axis. | LncRNA MIAT sponges miR-149-5p to inhibit efferocytosis in advanced atherosclerosis through CD47 upregulation.
Ye ZM, Yang S, Xia YP, Hu RT, Chen S, Li BW, Chen SL, Luo XY, Mao L, Li Y, Jin H, Qin C, Hu B., Free PMC Article | 04/11/2020 |
| Upregulation of MIAT can aggravate AS injury in AS mice. | Up-regulation of MIAT aggravates the atherosclerotic damage in atherosclerosis mice through the activation of PI3K/Akt signaling pathway.
Sun G, Li Y, Ji Z., Free PMC Article | 12/14/2019 |
| silence of MIAT protected ATDC5 cells against LPS challenge | Silence of lncRNA MIAT protects ATDC5 cells against lipopolysaccharides challenge via up-regulating miR-132.
Li C, Pan S, Song Y, Li Y, Qu J. | 12/7/2019 |
| Knockdown of hepatic Gomafu inhibited hepatic glucose production (HGP) and improved insulin sensitivity in obese mice. | Long noncoding RNA Gomafu upregulates Foxo1 expression to promote hepatic insulin resistance by sponging miR-139-5p.
Yan C, Li J, Feng S, Li Y, Tan L., Free PMC Article | 10/26/2019 |
| The study suggests that targeting MIAT may protect against cardiomyocytes against hypoxia-reperfusion injury or myocardial ischemia-reperfusion injury via inhibition of cell apoptosis, mediated by NF-kappaB and PUMA signaling pathway. | Targeting MIAT reduces apoptosis of cardiomyocytes after ischemia/reperfusion injury.
Chen L, Zhang D, Yu L, Dong H., Free PMC Article | 08/31/2019 |
| MIAT transcript levels were significantly elevated in breast cancer samples. Such increase was specific to the early stages of the disease. Silencing of MIAT induced growth arrest and increased basal apoptosis. | Long noncoding RNA MIAT regulates apoptosis and the apoptotic response to chemotherapeutic agents in breast cancer cell lines.
Almnaseer ZA, Mourtada-Maarabouni M., Free PMC Article | 04/20/2019 |
| Our study therefore has identified MIAT as the first pro-fibrotic lncRNA in heart and unraveled the role of MIAT in the pathogenesis of MI. | MIAT Is a Pro-fibrotic Long Non-coding RNA Governing Cardiac Fibrosis in Post-infarct Myocardium.
Qu X, Du Y, Shu Y, Gao M, Sun F, Luo S, Yang T, Zhan L, Yuan Y, Chu W, Pan Z, Wang Z, Yang B, Lu Y., Free PMC Article | 11/3/2018 |
| Observations suggest that Gomafu modifies mouse behavior thorough a mild modulation of gene expression and/or alternative splicing of target genes. | Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine.
Ip JY, Sone M, Nashiki C, Pan Q, Kitaichi K, Yanaka K, Abe T, Takao K, Miyakawa T, Blencowe BJ, Nakagawa S., Free PMC Article | 04/28/2018 |
| MIAT knockdown leads to cerebral microvascular degeneration, progressive neuronal loss and neurodegeneration, and behavioral deficits in a CNS neurovascular disorder, Alzheimer's disease model | Long non-coding RNA-MIAT promotes neurovascular remodeling in the eye and brain.
Jiang Q, Shan K, Qun-Wang X, Zhou RM, Yang H, Liu C, Li YJ, Yao J, Li XM, Shen Y, Cheng H, Yuan J, Zhang YY, Yan B., Free PMC Article | 02/24/2018 |