| effects of upd1 overexpression on lifespan | Effects of unpaired 1 gene overexpression on the lifespan of Drosophila melanogaster.
Moskalev A, Proshkina E, Zhavoronkov A, Shaposhnikov M., Free PMC Article | 02/8/2020 |
| a mechanism based on the dilution of the growth modulator Upd can explain how growth termination is controlled in the eye disc | Growth control in the Drosophila eye disc by the cytokine Unpaired.
Vollmer J, Fried P, Aguilar-Hidalgo D, Sánchez-Aragón M, Iannini A, Casares F, Iber D. | 09/16/2017 |
| adipose- and brain-derived upd/leptin may control differing features of weight regulation through distinct neural circuits. | A Leptin Analog Locally Produced in the Brain Acts via a Conserved Neural Circuit to Modulate Obesity-Linked Behaviors in Drosophila.
Beshel J, Dubnau J, Zhong Y., Free PMC Article | 07/15/2017 |
| ROS/JNK/p38/Upd stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration. | ROS-Induced JNK and p38 Signaling Is Required for Unpaired Cytokine Activation during Drosophila Regeneration.
Santabárbara-Ruiz P, López-Santillán M, Martínez-Rodríguez I, Binagui-Casas A, Pérez L, Milán M, Corominas M, Serras F., Free PMC Article | 06/4/2016 |
| in the Drosophila egg chamber, two anterior cells secrete Unpaired to activate Signal transducer and activator of transcription (STAT) signalling in the epithelium. | Tissue landscape alters adjacent cell fates during Drosophila egg development.
Manning LA, Weideman AM, Peercy BE, Starz-Gaiano M., Free PMC Article | 04/23/2016 |
| data suggest that Dally and Dlp are essential regulators for Upd distribution and JAK/STAT signaling activity in eye development | Drosophila glypicans Dally and Dally-like are essential regulators for JAK/STAT signaling and Unpaired distribution in eye development.
Zhang Y, You J, Ren W, Lin X., Free PMC Article | 04/20/2013 |
| Upd and JAK/STAT signaling induce apoptosis of supernumerary polar cells (PC) to control the size of the PC organizing center and thereby produce appropriate levels of Upd. | JAK/STAT autocontrol of ligand-producing cell number through apoptosis.
Borensztejn A, Boissoneau E, Fernandez G, Agnès F, Pret AM. | 02/2/2013 |
| findings demonstrate that the glypicans dally and dlp regulate formation of the follicular gradient of the Upd morphogen, Upd | Glypicans regulate JAK/STAT signaling and distribution of the Unpaired morphogen.
Hayashi Y, Sexton TR, Dejima K, Perry DW, Takemura M, Kobayashi S, Nakato H, Harrison DA., Free PMC Article | 01/26/2013 |
| Study isolated miR-279 as an effecter of clock-controlled behavioral output, and identified Upd, the ortholog of the JAK/STAT ligand, as the circadian-relevant target of this miRNA. | Regulation of circadian behavioral output via a MicroRNA-JAK/STAT circuit.
Luo W, Sehgal A., Free PMC Article | 04/7/2012 |
| not only is Upd specifically required in the mushroom bodies for olfactory aversive long-term memory but the Upd receptor Dome, as well as the Drosophila JAK and STAT homologs Hop and Stat92E, are also required | Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila.
Copf T, Goguel V, Lampin-Saint-Amaux A, Scaplehorn N, Preat T., Free PMC Article | 07/16/2011 |
| Genetically controls spermatogonial stem cell self-renewal. | Molecular control of spermatogonial stem cell self-renewal by glycoprotein unpaired, a cytokine homolog, in Drosophila melanogaster.
Tulina NM. | 01/21/2010 |
| The difference in effect between localized expression of ligand (Unpaired) and dominant active JAK (Hopscotch) demonstrates that the ligand plays a cell non-autonomous role in hindgut cell rearrangement. | Localized JAK/STAT signaling is required for oriented cell rearrangement in a tubular epithelium.
Johansen KA, Iwaki DD, Lengyel JA. | 01/21/2010 |
| the Upd/Jak/STAT signaling is required and sufficient to determine MF initiation by repressing the transcription of wingless (wg), which is known to block MF initiation | Upd/Jak/STAT signaling represses wg transcription to allow initiation of morphogenetic furrow in Drosophila eye development.
Tsai YC, Yao JG, Chen PH, Posakony JW, Barolo S, Kim J, Sun YH. | 01/21/2010 |
| hub cells in the testis are a localized source of the ligand Upd, which activates the JAK-STAT pathway in adjacent stem cells | Control of stem cell self-renewal in Drosophila spermatogenesis by JAK-STAT signaling.
Tulina N, Matunis E. | 01/21/2010 |
| activates the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway in adjacent germ cells to specify self-renewal and continual maintenance of the germ line stem cell population | Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue.
Kiger AA, Jones DL, Schulz C, Rogers MB, Fuller MT. | 01/21/2010 |
| Encodes the ligand for the Jak/STAT pathway and acts over long distance to promote cell proliferation. Controlled by N and eye gone. | Localized Notch signal acts through eyg and upd to promote global growth in Drosophila eye.
Chao JL, Tsai YC, Chiu SJ, Sun YH. | 01/21/2010 |