LINC00629, a HOXB4-downregulated long noncoding RNA, inhibits glycolysis and ovarian cancer progression by destabilizing c-Myc. | LINC00629, a HOXB4-downregulated long noncoding RNA, inhibits glycolysis and ovarian cancer progression by destabilizing c-Myc. Liu J, Zhu Y, Wang H, Han C, Wang Y, Tang R., Free PMC Article | 03/13/2024 |
[miRNA-181a-5p inhibits proliferation and migration of osteosarcoma cell line HOS by targeting HOXB4]. | [miRNA-181a-5p inhibits proliferation and migration of osteosarcoma cell line HOS by targeting HOXB4]. Li JX, He XJ, Li F, Lei YT, Yang YB, Li J, Zong GY, Zhao MC, Chang SE. | 11/26/2022 |
HOXB4 inhibits the proliferation and tumorigenesis of cervical cancer cells by downregulating the activity of Wnt/beta-catenin signaling pathway. | HOXB4 inhibits the proliferation and tumorigenesis of cervical cancer cells by downregulating the activity of Wnt/β-catenin signaling pathway. Lei D, Yang WT, Zheng PS., Free PMC Article | 10/9/2021 |
HOXB4 promotes the malignant progression of ovarian cancer via DHDDS. | HOXB4 promotes the malignant progression of ovarian cancer via DHDDS. Li N, Gou JH, Xiong J, You JJ, Li ZY., Free PMC Article | 11/21/2020 |
our data confirms that CaP growth and chemo-/radioresistance in vivo is associated with over-expression of EpCAM, which serves both a functional biomarker and promising therapeutic target. | MiR-10a and HOXB4 are overexpressed in atypical myeloproliferative neoplasms. Dumas PY, Mansier O, Prouzet-Mauleon V, Koya J, Villacreces A, Brunet de la Grange P, Luque Paz D, Bidet A, Pasquet JM, Praloran V, Salin F, Kurokawa M, Mahon FX, Cardinaud B, Lippert E., Free PMC Article | 02/16/2019 |
Data suggests that an impaired capacity of eutopic and ectopic endometrial tissue to upregulate levels of HOXB4 during the proliferative phase may play a role in the pathogenesis of endometriosis and that further downregulation of HOXB4 may enhance ectopic implant invasiveness. | HOXB4 Immunoreactivity in Endometrial Tissues From Women With or Without Endometriosis. AlKusayer GM, Pon JR, Peng B, Klausen C, Lisonkova S, Kinloch M, Yong P, Muhammad EMS, Leung PCK, Bedaiwy MA. | 11/17/2018 |
Authors observed that induced expression of HOXB4 in the UW473 cell line significantly reduced in vitro cell proliferation and migration capability of UW473 cells with no effect on the in vivo tumorigenicity. | Functional analysis of HOXA10 and HOXB4 in human medulloblastoma cell lines. Bonfim-Silva R, Ferreira Melo FU, Thomé CH, Abraham KJ, De Souza FAL, Ramalho FS, Machado HR, De Oliveira RS, Cardoso AA, Covas DT, Fontes AM. | 07/28/2018 |
Study revealed that HOXB4 was highly expressed in ovarian cancer cells. HOXB4 silencing enhanced the cytotoxic effect of Taxol and DDP by downregulating ABC transporters via inhibition of the PI3K/Akt signaling pathway. These results for the first time elucidated the critical roles and molecular basis of HOXB4 underlying drug resistance in ovarian cancer cells. | HOXB4 knockdown enhances the cytotoxic effect of paclitaxel and cisplatin by downregulating ABC transporters in ovarian cancer cells. Li Y, Sun J, Gao S, Hu H, Xie P. | 06/2/2018 |
HOXB4 knockout led to downregulation of P-glycoprotein, multidrug resistance-associated protein 1 and breast cancer resistance protein expression and PI3K/Akt signaling activity, suggesting that repression of HOXB4 might be a key point to reverse Multidrug resistance of K562/ADM cells. | HOXB4 knockdown reverses multidrug resistance of human myelogenous leukemia K562/ADM cells by downregulating P-gp, MRP1 and BCRP expression via PI3K/Akt signaling pathway. Wang H, Jia XH, Chen JR, Yi YJ, Wang JY, Li YJ, Xie SY. | 04/22/2017 |
This study provides novel evidences of the mechanisms integrating Notch and TNF-alpha signaling in the transcriptional induction of GATA3 and HOXB4. | TNF-alpha and Notch signaling regulates the expression of HOXB4 and GATA3 during early T lymphopoiesis. Dos Santos Schiavinato JL, Oliveira LH, Araujo AG, Orellana MD, de Palma PV, Covas DT, Zago MA, Panepucci RA. | 03/11/2017 |
Increased expression of HOXB4 in human embryonic stem cells enhances the production of hematopoietic Progenitors but does not effect the maturation of red blood cells. | Enforced Expression of HOXB4 in Human Embryonic Stem Cells Enhances the Production of Hematopoietic Progenitors but Has No Effect on the Maturation of Red Blood Cells. Jackson M, Ma R, Taylor AH, Axton RA, Easterbrook J, Kydonaki M, Olivier E, Marenah L, Stanley EG, Elefanty AG, Mountford JC, Forrester LM., Free PMC Article | 12/31/2016 |
The analysis of HOX expression in primary mesothelioma tumors indicated that these cells could also be sensitive to the disruption of HOX activity by HXR9, and that the expression of HOXB4 is strongly associated with overall survival | HOX transcription factors are potential targets and markers in malignant mesothelioma. Morgan R, Simpson G, Gray S, Gillett C, Tabi Z, Spicer J, Harrington KJ, Pandha HS., Free PMC Article | 10/1/2016 |
HOXA4 increases short-term repopulation to higher levels than HOXB4, which may involve Notch signaling to induce self-renewal of primitive hematopoietic cells | HOXA4 provides stronger engraftment potential to short-term repopulating cells than HOXB4. Fournier M, Lebert-Ghali CÉ, Bijl JJ., Free PMC Article | 08/13/2016 |
showed that OAC1 treatment led to OCT4-mediated upregulation of HOXB4 | Activation of OCT4 enhances ex vivo expansion of human cord blood hematopoietic stem and progenitor cells by regulating HOXB4 expression. Huang X, Lee MR, Cooper S, Hangoc G, Hong KS, Chung HM, Broxmeyer HE., Free PMC Article | 06/4/2016 |
decreased methylation at HOXB3 and HOXB4 was associated with increased gene expression of both HOXB genes specific to the mid-risk AML, while increased DNA methylation at DCC distinctive to the high-risk AML was associated with increased gene expression | Identification of differentially methylated markers among cytogenetic risk groups of acute myeloid leukemia. Qu X, Davison J, Du L, Storer B, Stirewalt DL, Heimfeld S, Estey E, Appelbaum FR, Fang M., Free PMC Article | 03/12/2016 |
a crucial regulator of NK lytic function | Enhanced cytotoxic activity of ex vivo-differentiated human natural killer cells in the presence of HOXB4. Nanbakhsh A, Pochon C, Amsellem S, Pittari G, Tejchman A, Bourhis JH, Chouaib S. | 04/18/2015 |
Epigenetic analysis revealed that increased promoter methylation of HOXB4 correlates with decreased expression of its transcript in oral cancer cell lines. HOXB4 may work as an epigenetic biomarker gene. | Epigenetic repression of HOXB cluster in oral cancer cell lines. Xavier FC, Destro MF, Duarte CM, Nunes FD. | 01/31/2015 |
Our study demonstrates for the first time the regulation of HOXB4 by miR-23a | Identification of the transcription factor HOXB4 as a novel target of miR-23a. Koller K, Das S, Leuschner I, Korbelius M, Hoefler G, Guertl B. | 11/2/2013 |
our results outline the effects of HOXB4 in combination with stromal cells in the development of NK cells from embryonic stem cells. | The HOXB4 homeoprotein promotes the ex vivo enrichment of functional human embryonic stem cell-derived NK cells. Larbi A, Gombert JM, Auvray C, l'Homme B, Magniez A, Féraud O, Coulombel L, Chapel A, Mitjavila-Garcia MT, Turhan AG, Haddad R, Bennaceur-Griscelli A., Free PMC Article | 03/23/2013 |
GATA-2 directly regulates HOXB4 expression in hematopoietic stem cells, which may play an important role in the development and/or progression of aplastic anemia. | Gene expression profiling identifies HOXB4 as a direct downstream target of GATA-2 in human CD34+ hematopoietic cells. Fujiwara T, Yokoyama H, Okitsu Y, Kamata M, Fukuhara N, Onishi Y, Fujimaki S, Takahashi S, Ishizawa K, Bresnick EH, Harigae H., Free PMC Article | 03/23/2013 |
HOXB4-positivity as an independent predictor of overall survival of acute myeloid leukemia patients | Prognostic significance of HOXB4 in de novo acute myeloid leukemia. Umeda S, Yamamoto K, Murayama T, Hidaka M, Kurata M, Ohshima T, Suzuki S, Sugawara E, Kawano F, Kitagawa M. | 01/5/2013 |
Expressions of ABCB1, BMI-1, HOXB4 were not detected in the patients with non-malignant hematologic diseases, but were higher in de novo acute leukemia patients and lower in patients in complete remission. | [Clinical significance of leukemia stem/progenitor cell related gene expression in acute leukemia]. Zhu HB, Zhao MF, Xie F, Xiao X, Xu XN, Mu J, Yang JW, Liu PJ, Lü HR, Li YM. | 12/8/2012 |
Comparative transcriptome analysis of CD34(+) cells subjected or not to HOXB4 or HOXC4 demonstrated that both homeoproteins regulate the same set of genes, some of which encode key hematopoietic factors and signaling molecules. | HOXC4 homeoprotein efficiently expands human hematopoietic stem cells and triggers similar molecular alterations as HOXB4. Auvray C, Delahaye A, Pflumio F, Haddad R, Amsellem S, Miri-Nezhad A, Broix L, Yacia A, Bulle F, Fichelson S, Vigon I., Free PMC Article | 09/22/2012 |
cytomegalovirus infection markedly down-regulated HOXB4 expression which affected proliferation and differentiation of erythroid and lymphocyte progenitor cells. | Studies on HOXB4 expression during differentiation of human cytomegalovirus-infected hematopoietic stem cells into lymphocyte and erythrocyte progenitor cells. Wen-jun L, qu-lian G, Hong-ying C, Yan Z, Mei-Xian H. | 09/8/2012 |
Down-regulation of mitochondria and lysosomal genes by HoxB4 plays a role in the impaired lymphoid lineage development from embryonic stem cells-derived hematopoietic stem cells. | Dynamic HoxB4-regulatory network during embryonic stem cell differentiation to hematopoietic cells. Fan R, Bonde S, Gao P, Sotomayor B, Chen C, Mouw T, Zavazava N, Tan K., Free PMC Article | 07/21/2012 |