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    HK3 hexokinase 3 [ Homo sapiens (human) ]

    Gene ID: 3101, updated on 17-Jun-2019

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Upregulation of HK3 is associated with EMT in CRC and may be a crucial metabolic adaptation for rapid proliferation, survival, and metastases of CRC cells

    HK3 overexpression associated with epithelial-mesenchymal transition in colorectal cancer.
    Pudova EA, Kudryavtseva AV, Fedorova MS, Zaretsky AR, Shcherbo DS, Lukyanova EN, Popov AY, Sadritdinova AF, Abramov IS, Kharitonov SL, Krasnov GS, Klimina KM, Koroban NV, Volchenko NN, Nyushko KM, Melnikova NV, Chernichenko MA, Sidorov DV, Alekseev BY, Kiseleva MV, Kaprin AD, Dmitriev AA, Snezhkina AV., Free PMC Article

    HK3 expression is significantly upregulated in human masticatory mucosa during wound healing

    Human gingiva transcriptome during wound healing.
    Wang Y, Tatakis DN.

    The transport of glucose across the cell membrane by glucose transporters (GLUTs) and intracellular phosphorylation by hexokinases (HKs) are the initial steps of the glycolytic pathway.

    High 18F-FDG uptake in PMAH correlated with normal expression of Glut1, HK1, HK2, and HK3.
    Cavalcante IP, Zerbini MC, Alencar GA, Mariani Bde P, Buchpiguel CA, Almeida MQ, Mendonca BB, Fragoso MC.

    HK1 and HK2 expression alterations were detected, that could be explained by common deregulation mechanisms of these genes in colorectal tumors. The HK3 expression level was significantly increased in 60% of samples.

    [Evaluation of Gene Expression of Hexokinases in Colorectal Cancer with the Use of Bioinformatics Methods].
    Krasnov GS, Dmitriev AA, Sadtritdinova AF, Fedorova MS, Snezhkina AV, Melnikova NV, Poteryakhina AV, Nyushko KM, Belyakov MM, Kaprin AD, Zaretsky AR, Kudryavtseva AV.

    Through glycolysis and arachidonic acid metabolism, HK3 and PTGS2 might play important roles in pediatric ALL and its prognosis, and thus, might be potential targets for therapeutic intervention to suppress pediatric ALL.

    Identification of key genes affecting disease free survival time of pediatric acute lymphoblastic leukemia based on bioinformatic analysis.
    Gao HY, Luo XG, Chen X, Wang JH.

    Altogether, our data provide an explanation for low HK3 and KLF5 expression in particular AML subtype and establish these genes as novel CEBPA targets during neutrophil differentiation.

    CEBPA-dependent HK3 and KLF5 expression in primary AML and during AML differentiation.
    Federzoni EA, Humbert M, Torbett BE, Behre G, Fey MF, Tschan MP., Free PMC Article

    HK3 is: (1) directly activated by PU.1, (2) repressed by PML-RARA, and (3) functionally involved in neutrophil differentiation and cell viability of acute promyelocytic leukemia cells.

    PU.1 is linking the glycolytic enzyme HK3 in neutrophil differentiation and survival of APL cells.
    Federzoni EA, Valk PJ, Torbett BE, Haferlach T, Löwenberg B, Fey MF, Tschan MP., Free PMC Article

    Data demonstrated that in addition to galectin-3, HK III and cyclin A profiles could be important biomarkers in predicting malignancy in follicular thyroid nodules.

    Hexokinase III, cyclin A and galectin-3 are overexpressed in malignant follicular thyroid nodules.
    Hooft L, van der Veldt AA, Hoekstra OS, Boers M, Molthoff CF, van Diest PJ.

    Data show that HKIII exerts protective effects against oxidative stress, perhaps by increasing ATP levels, reducing oxidant-induced ROS production, preserving mitochondrial membrane potential, and increasing mitochondrial biogenesis.

    Regulation and cytoprotective role of hexokinase III.
    Wyatt E, Wu R, Rabeh W, Park HW, Ghanefar M, Ardehali H., Free PMC Article

    Observational study of gene-disease association. (HuGE Navigator)

    Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article

    Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)

    Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.
    He C, Kraft P, Chen C, Buring JE, Paré G, Hankinson SE, Chanock SJ, Ridker PM, Hunter DJ, Chasman DI., Free PMC Article

    The expression pattern of HK3 is reported in newly diagnosed esophageal adenocarcinoma by means of immunohistochemistry.

    Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma.
    Fonteyne P, Casneuf V, Pauwels P, Van Damme N, Peeters M, Dierckx R, Van de Wiele C.

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