| Homodimeric Granzyme A Opsonizes Mycobacterium tuberculosis and Inhibits Its Intracellular Growth in Human Monocytes via Toll-Like Receptor 4 and CD14. | Homodimeric Granzyme A Opsonizes Mycobacterium tuberculosis and Inhibits Its Intracellular Growth in Human Monocytes via Toll-Like Receptor 4 and CD14.
Rasi V, Phelps KR, Paulson KR, Eickhoff CS, Chinnaraj M, Pozzi N, Di Gioia M, Zanoni I, Shakya S, Carlson HL, Ford DA, Kolar GR, Hoft DF., | 03/18/2024 |
| Heterogeneity induced GZMA-F2R communication inefficient impairs antitumor immunotherapy of PD-1 mAb through JAK2/STAT1 signal suppression in hepatocellular carcinoma. | Heterogeneity induced GZMA-F2R communication inefficient impairs antitumor immunotherapy of PD-1 mAb through JAK2/STAT1 signal suppression in hepatocellular carcinoma.
Gao Y, Xu Q, Li X, Guo Y, Zhang B, Jin Y, Zhu C, Shen Y, Yang P, Shi Y, Jin R, Liu D, Ouyang Y, Liu X, Wang W, Chen D, Yang T., Free PMC Article | 04/23/2022 |
| Elevated Extracellular Levels of Granzymes in Patients with Scrub Typhus. | Elevated Extracellular Levels of Granzymes in Patients with Scrub Typhus.
Hwang JH, Hwang JH, Lee CS., Free PMC Article | 02/26/2022 |
| Granzyme A Produced by gamma9delta2 T Cells Activates ER Stress Responses and ATP Production, and Protects Against Intracellular Mycobacterial Replication Independent of Enzymatic Activity. | Granzyme A Produced by γ(9)δ(2) T Cells Activates ER Stress Responses and ATP Production, and Protects Against Intracellular Mycobacterial Replication Independent of Enzymatic Activity.
Rasi V, Wood DC, Eickhoff CS, Xia M, Pozzi N, Edwards RL, Walch M, Bovenschen N, Hoft DF., Free PMC Article | 12/25/2021 |
| Lighting a Fire: Can We Harness Pyroptosis to Ignite Antitumor Immunity? | Lighting a Fire: Can We Harness Pyroptosis to Ignite Antitumor Immunity?
Zhang Z, Zhang Y, Lieberman J., Free PMC Article | 10/23/2021 |
| Novel tumour suppressor roles for GZMA and RASGRP1 in Theileria annulata-transformed macrophages and human B lymphoma cells. | Novel tumour suppressor roles for GZMA and RASGRP1 in Theileria annulata-transformed macrophages and human B lymphoma cells.
Rchiad Z, Haidar M, Ansari HR, Tajeri S, Mfarrej S, Ben Rached F, Kaushik A, Langsley G, Pain A., Free PMC Article | 08/7/2021 |
| Extracellular Granzyme A Promotes Colorectal Cancer Development by Enhancing Gut Inflammation. | Extracellular Granzyme A Promotes Colorectal Cancer Development by Enhancing Gut Inflammation.
Santiago L, Castro M, Sanz-Pamplona R, Garzón M, Ramirez-Labrada A, Tapia E, Moreno V, Layunta E, Gil-Gómez G, Garrido M, Peña R, Lanuza PM, Comas L, Jaime-Sanchez P, Uranga-Murillo I, Del Campo R, Pelegrín P, Camerer E, Martínez-Lostao L, Muñoz G, Uranga JA, Alcalde A, Galvez EM, Ferrandez A, Bird PI, Metkar S, Arias MA, Pardo J. | 05/1/2021 |
| Granzyme A in Chikungunya and Other Arboviral Infections. | Granzyme A in Chikungunya and Other Arboviral Infections.
Schanoski AS, Le TT, Kaiserman D, Rowe C, Prow NA, Barboza DD, Santos CA, Zanotto PMA, Magalhães KG, Aurelio L, Muller D, Young P, Zhao P, Bird PI, Suhrbier A., Free PMC Article | 11/21/2020 |
| COVID-19 pneumonia: CD8(+) T and NK cells are decreased in number but compensatory increased in cytotoxic potential. | COVID-19 pneumonia: CD8(+) T and NK cells are decreased in number but compensatory increased in cytotoxic potential.
Jiang Y, Wei X, Guan J, Qin S, Wang Z, Lu H, Qian J, Wu L, Chen Y, Chen Y, Lin X., Free PMC Article | 08/29/2020 |
| this study demonstrated that GZMA from cytotoxic lymphocytes cleaves and activates GSDMB to induce target cell pyroptosis. | Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells.
Zhou Z, He H, Wang K, Shi X, Wang Y, Su Y, Wang Y, Li D, Liu W, Zhang Y, Shen L, Han W, Shen L, Ding J, Shao F. | 06/13/2020 |
| GzmA produced by lesional CD8 T cells has the capacity to specifically increase chemokine secretion from inflamed keratinocytes, thereby sustaining the focal inflammation in psoriasis lesions by amplifying a chemotactic inflammatory loop. | Granzyme A potentiates chemokine production in IL-17-stimulated keratinocytes.
Cheuk S, Martini E, Bergh K, Chang D, Rethi B, Ståhle M, Eidsmo L. | 07/14/2018 |
| granzyme A in human platelets increases with aging | Granzyme A in Human Platelets Regulates the Synthesis of Proinflammatory Cytokines by Monocytes in Aging.
Campbell RA, Franks Z, Bhatnagar A, Rowley JW, Manne BK, Supiano MA, Schwertz H, Weyrich AS, Rondina MT., Free PMC Article | 01/6/2018 |
| GzmA plays an unfavorable role in host defense during pneumococcal pneumonia by a mechanism that does not depend on natural killer cells. | Granzyme A impairs host defense during Streptococcus pneumoniae pneumonia.
van den Boogaard FE, van Gisbergen KP, Vernooy JH, Medema JP, Roelofs JJ, van Zoelen MA, Endeman H, Biesma DH, Boon L, Van't Veer C, de Vos AF, van der Poll T. | 05/27/2017 |
| Carbamate pesticides significantly reduced the intracellular levels of perforin, GrA, GrB, Gr3/K, and GRN in NK-92CI cells. | Effect of carbamate pesticides on perforin, granzymes A-B-3/K, and granulysin in human natural killer cells.
Li Q, Kobayashi M, Kawada T. | 04/8/2017 |
| Our results suggest that granzyme A could be considered another biomarker of TB, that can be used, other than IFN-gamma, to discriminate between patients with active TB and LTBI subjects | Granzyme A as a potential biomarker of Mycobacterium tuberculosis infection and disease.
Guggino G, Orlando V, Cutrera S, La Manna MP, Di Liberto D, Vanini V, Petruccioli E, Dieli F, Goletti D, Caccamo N. | 09/19/2016 |
| Delivered into parasite infected cells by granulysin and perforin, granzymes generate superoxide and inactivate oxidative defense enzymes to kill the parasite. | Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites.
Dotiwala F, Mulik S, Polidoro RB, Ansara JA, Burleigh BA, Walch M, Gazzinelli RT, Lieberman J., Free PMC Article | 07/2/2016 |
| Taken together, the authors verified that histone H3 is a real substrate for GzmA in vivo in the Raji cells treated by staurosporin. | Histone H3 is Digested by Granzyme A During Compromised Cell Death in the Raji Cells.
Lee PY, Park BC, Chi SW, Bae KH, Kim S, Cho S, Kim JH, Park SG. | 06/28/2016 |
| Results reveal enhanced intra- and extracellular expression of gzmA and B in patients with pulmonary TB, suggesting that gzms are part of the host response to tuberculosis. | Increased intra- and extracellular granzyme expression in patients with tuberculosis.
Garcia-Laorden MI, Blok DC, Kager LM, Hoogendijk AJ, van Mierlo GJ, Lede IO, Rahman W, Afroz R, Ghose A, Visser CE, Md Zahed AS, Husain MA, Alam KM, Chandra Barua P, Hassan M, Hossain A, Tayab MA, Day N, Dondorp AM, de Vos AF, van der Poll T. | 06/4/2016 |
| Levels of GZMA and ITGAE mRNAs in colon tissues can identify patients with UC who are most likely to benefit from etrolizumab; expression levels decrease with etrolizumab administration in biomarker(high) patients. | Association Between Response to Etrolizumab and Expression of Integrin αE and Granzyme A in Colon Biopsies of Patients With Ulcerative Colitis.
Tew GW, Hackney JA, Gibbons D, Lamb CA, Luca D, Egen JG, Diehl L, Eastham Anderson J, Vermeire S, Mansfield JC, Feagan BG, Panes J, Baumgart DC, Schreiber S, Dotan I, Sandborn WJ, Kirby JA, Irving PM, De Hertogh G, Van Assche GA, Rutgeerts P, O'Byrne S, Hayday A, Keir ME. | 06/4/2016 |
| GzmA and GzmB expressing cells in the airways and lung parenchyma was higher in subjects who died from asthma | Increased expression of granzymes A and B in fatal asthma.
Annoni R, Silva LF, Nussbaumer-Ochsner Y, van Schadewijk A, Mauad T, Hiemstra PS, Rabe KF. | 04/9/2016 |
| GZMA, GBP5 and CD64 genes show promise as a rapid diagnostic markers separating tuberculosis from other pulmonary diseases. | A real-time PCR signature to discriminate between tuberculosis and other pulmonary diseases.
Laux da Costa L, Delcroix M, Dalla Costa ER, Prestes IV, Milano M, Francis SS, Unis G, Silva DR, Riley LW, Rossetti ML., Free PMC Article | 03/26/2016 |
| Data indicate N-terminomics on the human and mouse granzymes A and K by combined fractional diagonal chromatography (COFRADIC). | Substrate specificities of the granzyme tryptases A and K.
Plasman K, Demol H, Bird PI, Gevaert K, Van Damme P. | 10/31/2015 |
| We herewith identify GZMA as critical effector molecule of human Treg function for gastrointestinal immune response in an experimental GvHD model. | Granzyme A Is Required for Regulatory T-Cell Mediated Prevention of Gastrointestinal Graft-versus-Host Disease.
Velaga S, Ukena SN, Dringenberg U, Alter C, Pardo J, Kershaw O, Franzke A., Free PMC Article | 10/17/2015 |
| The exocytosed granzyme A enters target cells and mediates IL-1beta maturation independently of caspase-1 and without inducing cytotoxicity. | Granzyme A produces bioactive IL-1β through a nonapoptotic inflammasome-independent pathway.
Hildebrand D, Bode KA, Rieß D, Cerny D, Waldhuber A, Römmler F, Strack J, Korten S, Orth JH, Miethke T, Heeg K, Kubatzky KF. | 07/25/2015 |
| Serum concentrations of granzyme A in patients with ovarian cancer were substantially increased in comparison to concentrations in patients with ovarian cystadenomas or ovarian teratomas. | Cytotoxic reaction mediators: granzymes A and B in women with ovarian cancer.
Mielczarek-Palacz A, Sikora J, Kondera-Anasz Z, Bednarek I. | 01/10/2015 |