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    GTF2H2 general transcription factor IIH subunit 2 [ Homo sapiens (human) ]

    Gene ID: 2966, updated on 17-Jun-2019

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    interface variants between the p34 and p44 subunits only mildly affected the association between the full length proteins and did not impinge on TFIIH activities due to the presence of an additional interface involving the C4 domain of p34.

    The intricate network between the p34 and p44 subunits is central to the activity of the transcription/DNA repair factor TFIIH.
    Radu L, Schoenwetter E, Braun C, Marcoux J, Koelmel W, Schmitt DR, Kuper J, Cianférani S, Egly JM, Poterszman A, Kisker C., Free PMC Article

    Advanced oxidation protein products down-regulate the expression of calcium transport channels through p44/42 MAPK signaling mechanisms in the small intestinal epithelium.

    Advanced oxidation protein products decrease the expression of calcium transport channels in small intestinal epithelium via the p44/42 MAPK signaling pathway.
    Wu P, Xie F, Xue M, Xu X, He S, Lin M, Bai L.

    Together, these results suggest that p44/WDR77 expression causes the non-sensitivity of proliferating cells to TGFbeta signaling, thereby contributing to cellular proliferation during lung tumorigenesis.

    P44/WDR77 restricts the sensitivity of proliferating cells to TGFβ signaling.
    Yi P, Gao S, Gu Z, Huang T, Wang Z.

    No correlation was found for p44 and occludin gene copy number and spinal muscular atrophy

    Correlation of SMN2, NAIP, p44, H4F5 and Occludin genes copy number with spinal muscular atrophy phenotype in Tunisian patients.
    Amara A, Adala L, Ben Charfeddine I, Mamaï O, Mili A, Lazreg TB, H'mida D, Amri F, Salem N, Boughammura L, Saad A, Gribaa M.

    miR-27a was identified as a key regulator of p44 mRNA. Moreover, miR-27a was shown to destabilize the p44 subunit of the TFIIH complex during the G2-M phase, thereby modulating the transcriptional shutdown observed during this transition.

    MicroRNA-27a regulates basal transcription by targeting the p44 subunit of general transcription factor IIH.
    Portal MM., Free PMC Article

    Observational study of gene-disease association. (HuGE Navigator)

    A population-based study of genotypic and phenotypic variability in children with spinal muscular atrophy.
    Arkblad E, Tulinius M, Kroksmark AK, Henricsson M, Darin N.

    p52 Mediates XPB function within the transcription/repair factor

    p52 Mediates XPB function within the transcription/repair factor TFIIH.
    Jawhari A, Lainé JP, Dubaele S, Lamour V, Poterszman A, Coin F, Moras D, Egly JM.

    p44 of TFIIH has a role in binding to the nonstructural protein of Rift Valley fever virus to form nuclear filamentous structures

    TFIIH transcription factor, a target for the Rift Valley hemorrhagic fever virus.
    Le May N, Dubaele S, Proietti De Santis L, Billecocq A, Bouloy M, Egly JM.

    solution structure of p44-(321-395) shows topology differs from other reported RING domains by a circular permutation of the extended secondary structure elements; mutagenesis suggests tight binding to p34 is mediated by hydrophobic interactions

    Solution structure of the C-terminal domain of TFIIH P44 subunit reveals a novel type of C4C4 ring domain involved in protein-protein interactions.
    Kellenberger E, Dominguez C, Fribourg S, Wasielewski E, Moras D, Poterszman A, Boelens R, Kieffer B.

    Impaired transcription in IPF is associated with decreased concentrations of transcription factor II-H in alveolar macrophages and may alter the intraalveolar milieu in IPF.

    Impairment of alveolar macrophage transcription in idiopathic pulmonary fibrosis.
    Ren P, Rosas IO, Macdonald SD, Wu HP, Billings EM, Gochuico BR., Free PMC Article

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