The epigenetic downregulation of LncGHRLOS mediated by RNA m6A methylase ZCCHC4 promotes colorectal cancer tumorigenesis. | The epigenetic downregulation of LncGHRLOS mediated by RNA m6A methylase ZCCHC4 promotes colorectal cancer tumorigenesis. Chen K, Zhang J, Meng L, Kong L, Lu M, Wang Z, Wang W., Free PMC Article | 02/14/2024 |
ZCCHC4 Promotes Osteosarcoma Progression by Upregulating ITGB1. | ZCCHC4 Promotes Osteosarcoma Progression by Upregulating ITGB1. Luo L, Tang X, Liu L, Tang G, Chen L, Chang G, Xiao Z. | 08/25/2023 |
RNA-binding protein ZCCHC4 promotes human cancer chemoresistance by disrupting DNA-damage-induced apoptosis. | RNA-binding protein ZCCHC4 promotes human cancer chemoresistance by disrupting DNA-damage-induced apoptosis. Zhu H, Chen K, Chen Y, Liu J, Zhang X, Zhou Y, Liu Q, Wang B, Chen T, Cao X., Free PMC Article | 07/30/2022 |
In summary, we establish ZCCHC4 as the enzyme responsible for m6A modification of human 28S rRNA, and demonstrate its functional significance in mRNA translation. | The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA. Pinto R, Vågbø CB, Jakobsson ME, Kim Y, Baltissen MP, O'Donohue MF, Guzmán UH, Małecki JM, Wu J, Kirpekar F, Olsen JV, Gleizes PE, Vermeulen M, Leidel SA, Slupphaug G, Falnes PØ., Free PMC Article | 03/21/2020 |
3.1 A-resolution crystal structure of human CCHC zinc finger-containing protein ZCCHC4, a 28S rRNA-specific m(6)A methyltransferase, bound to S-adenosyl-L-homocysteine. Mutational and enzymatic analyses further substantiate the molecular basis for ZCCHC4-RNA recognition and a role of the stem-loop structure within substrate in governing the substrate specificity. | Structure and regulation of ZCCHC4 in m(6)A-methylation of 28S rRNA. Ren W, Lu J, Huang M, Gao L, Li D, Wang GG, Song J., Free PMC Article | 03/7/2020 |
ZCCHC4 protein is overexpressed in hepatocellular carcinoma tumors.ZCCHC4 is an m6A RNA methyltransferase. | N(6-)Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation. Ma H, Wang X, Cai J, Dai Q, Natchiar SK, Lv R, Chen K, Lu Z, Chen H, Shi YG, Lan F, Fan J, Klaholz BP, Pan T, Shi Y, He C., Free PMC Article | 05/11/2019 |