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    GPR34 G protein-coupled receptor 34 [ Homo sapiens (human) ]

    Gene ID: 2857, updated on 2-Oct-2018

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    By monitoring fused FLAG-tag and conformation-sensitive native epitope during expression of GPR34 mutants, a tri-basic motif in the first intracellular loop was identified as key topogenic signal that dictates the orientation of transmembrane domain-1.

    Topogenesis and cell surface trafficking of GPR34 are facilitated by positive-inside rule that effects through a tri-basic motif in the first intracellular loop.
    Hasegawa H, Patel N, Ettehadieh E, Li P, Lim AC.

    09/10/2016
    GPR34 knockdown impairs the proliferation and migration of HGC-27 gastric cancer cells in vitro and provides a potential implication for therapy of gastric cancer.

    G-protein coupled receptor 34 knockdown impairs the proliferation and migration of HGC-27 gastric cancer cells in vitro.
    Jin ZT, Li K, Li M, Ren ZG, Wang FS, Zhu JY, Leng XS, Yu WD., Free PMC Article

    10/3/2015
    up-regulation of GPR34 expression in human gastric carcinoma may play a critical role in tumor progression and in determining patient prognosis

    Upregulation of GPR34 expression affects the progression and prognosis of human gastric adenocarcinoma by PI3K/PDK1/AKT pathway.
    Yu W, Ma S, Wang L, Zuo B, Li M, Qiao Z, Pan X, Liu Y, Wang J.

    06/28/2014
    The present studies confirm that GPR34 is a cellular receptor for LysoPS, especially with a fatty acid at the sn-2 position.

    GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position.
    Kitamura H, Makide K, Shuto A, Ikubo M, Inoue A, Suzuki K, Sato Y, Nakamura S, Otani Y, Ohwada T, Aoki J.

    02/2/2013
    these results are the first to identify a role for a GPR34 in lymphoma cell growth, provide insight into GPR34-mediated signaling, identify a genetically unique subset of MZLs that express high levels of GPR34.

    t(X;14)(p11;q32) in MALT lymphoma involving GPR34 reveals a role for GPR34 in tumor cell growth.
    Ansell SM, Akasaka T, McPhail E, Manske M, Braggio E, Price-Troska T, Ziesmer S, Secreto F, Fonseca R, Gupta M, Law M, Witzig TE, Dyer MJ, Dogan A, Cerhan JR, Novak AJ., Free PMC Article

    01/26/2013
    data show that multiple translation initiation starts and alternative splicing contribute to the supragenomic diversification of GPR34

    Genomic and supragenomic structure of the nucleotide-like G-protein-coupled receptor GPR34.
    Engemaier E, Römpler H, Schöneberg T, Schulz A.

    01/21/2010
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