| Stress fiber strain recognition by the LIM protein testin is cryptic and mediated by RhoA. | Stress fiber strain recognition by the LIM protein testin is cryptic and mediated by RhoA.
Sala S, Oakes PW., Free PMC Article | 01/22/2022 |
| Chitinase 3-Like 1, Nestin, and Testin Proteins as Novel Biomarkers of Potential Clinical Use in Colorectal Cancer: A Review. | Chitinase 3-Like 1, Nestin, and Testin Proteins as Novel Biomarkers of Potential Clinical Use in Colorectal Cancer: A Review.
Szymańska-Chabowska A, Juzwiszyn J, Jankowska-Polańska B, Tański W, Chabowski M. | 09/19/2020 |
| Expression of testin is downregulated in the hearts of patients with dilated cardiomyopathy. | Testin protects against cardiac hypertrophy by targeting a calcineurin-dependent signalling pathway.
Gao L, Liu Y, Guo S, Xiao L, Liang C, Wang X., Free PMC Article | 06/13/2020 |
| TES-mediated upregulation of the transcription factor DDIT3 is involved in CFP suppression of breast cancer cell growth | CFP suppresses breast cancer cell growth by TES-mediated upregulation of the transcription factor DDIT3.
Block I, Müller C, Sdogati D, Pedersen H, List M, Jaskot AM, Syse SD, Lund Hansen P, Schmidt S, Christiansen H, Casella C, Bering Olsen S, Blomstrøm MM, Riedel A, Thomassen M, Kruse TA, Karlskov Hansen SW, Kioschis P, Mollenhauer J. | 01/4/2020 |
| These findings provide a better understanding of the development and progression of gastric cancer (GC) and indicate that TES may be used as a potential prognostic marker and therapeutic target for GC patients. | TES functions as a Mena-dependent tumor suppressor in gastric cancer carcinogenesis and metastasis.
Wang DD, Chen YB, Zhao JJ, Zhang XF, Zhu GC, Weng DS, Pan K, Lv L, Pan QZ, Jiang SS, Wang LL, Xia JC., Free PMC Article | 08/24/2019 |
| Testin and filamin-C downregulation by acetylated Siah2 increases invasiveness of Helicobacter pylori-infected gastric cancer cells. | Testin and filamin-C downregulation by acetylated Siah2 increases invasiveness of Helicobacter pylori-infected gastric cancer cells.
Kokate SB, Dixit P, Poirah I, Roy AD, Chakraborty D, Rout N, Singh SP, Ashktorab H, Smoot DT, Bhattacharyya A. | 05/4/2019 |
| validated two new TES cocomplex partners: TGFB1I1 and a short form of the glucocorticoid receptor. TES and TGFB1I1 are shown to oppositely affect cell spreading providing biological validity for their copresence in complexes since they act in similar processes | Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.
Sala S, Van Troys M, Medves S, Catillon M, Timmerman E, Staes A, Schaffner-Reckinger E, Gevaert K, Ampe C. | 03/10/2018 |
| these data indicate that TES functions as a necessary suppressor of colorectal cancer progression by activating p38-MAPK signaling pathways. | TES inhibits colorectal cancer progression through activation of p38.
Li H, Huang K, Gao L, Wang L, Niu Y, Liu H, Wang Z, Wang L, Wang G, Wang J., Free PMC Article | 01/13/2018 |
| testin region (amino acids 52-233) harbouring the PET domain interacts with the C-terminal LIM1-2 domains | The PET and LIM1-2 domains of testin contribute to intramolecular and homodimeric interactions.
Sala S, Catillon M, Hadzic E, Schaffner-Reckinger E, Van Troys M, Ampe C., Free PMC Article | 09/16/2017 |
| Testin plays an important role in the development and progression of non-small cell lung cancer. Testin is a tumor suppressor. | Testin is a tumor suppressor in non-small cell lung cancer.
Wang M, Wang Q, Peng WJ, Hu JF, Wang ZY, Liu H, Huang LN. | 03/25/2017 |
| VASP, zyxin and TES are tension-dependent members of focal adherens junctions independent of the alpha-catenin-vinculin module. | VASP, zyxin and TES are tension-dependent members of Focal Adherens Junctions independent of the α-catenin-vinculin module.
Oldenburg J, van der Krogt G, Twiss F, Bongaarts A, Habani Y, Slotman JA, Houtsmuller A, Huveneers S, de Rooij J., Free PMC Article | 10/8/2016 |
| we confirm that the TES promoter is unmethylated in normal adult and fetal tissues. Re-expression of TESTIN protein in acute lymphoblastic leukemia cells using expression plasmid transfection results in rapid cell death or cell cycle arrest. | TESTIN Induces Rapid Death and Suppresses Proliferation in Childhood B Acute Lymphoblastic Leukaemia Cells.
Weeks RJ, Ludgate JL, LeMée G, Morison IM., Free PMC Article | 08/6/2016 |
| Loss of TES gene expression is associated with nasopharyngeal carcinoma. | Effects of TESTIN gene expression on proliferation and migration of the 5-8F nasopharyngeal carcinoma cell line.
Zhong Z, Zhang F, Yin SC. | 02/6/2016 |
| findings suggest that the TES gene is a novel tumor suppressor gene | Downregulation of TES by hypermethylation in glioblastoma reduces cell apoptosis and predicts poor clinical outcome.
Bai Y, Zhang QG, Wang XH., Free PMC Article | 12/19/2015 |
| TESTIN was hypermethylated in 43.7% endometrial cancer tissues (p < 0.001). Moreover, TESTIN hypermethylation was significantly correlated with advanced tumor stage, deep myometrial invasion and lymphatic node metastasis. | TESTIN was commonly hypermethylated and involved in the epithelial-mesenchymal transition of endometrial cancer.
Dong R, Pu H, Wang Y, Yu J, Lian K, Mao C. | 07/25/2015 |
| Downregulation of TES was associated with breast cancer. | TES was epigenetically silenced and suppressed the epithelial-mesenchymal transition in breast cancer.
Yongbin Y, Jinghua L, Zhanxue Z, Aimin Z, Youchao J, Yanhong S, Manjing J. | 04/18/2015 |
| TESTIN was commonly downregulated in human endometrial carcinoma and was associated with poor prognostic markers. | TESTIN suppresses tumor growth and invasion via manipulating cell cycle progression in endometrial carcinoma.
Gu Z, Ding G, Liang K, Zhang H, Guo G, Zhang L, Cui J., Free PMC Article | 12/20/2014 |
| A further significant correlation was observed between TES downregulation and the luminal B subtype independent of survivin expression. | Differential expression of testin and survivin in breast cancer subtypes.
Sarti M, Pinton S, Limoni C, Carbone GM, Pagani O, Cavalli F, Catapano CV. | 03/1/2014 |
| TES, as a valuable marker of breast cancer prognosis, plays an important role in the development and progression of breast cancer. TES may be an effective novel target in breast cancer prevention and treatment. | Testin is a tumor suppressor and prognostic marker in breast cancer.
Zhu J, Li X, Kong X, Moran MS, Su P, Haffty BG, Yang Q., Free PMC Article | 03/2/2013 |
| Low TES gene expression is associated with coronary artery disease. | Comparative gene expression analysis between coronary arteries and internal mammary arteries identifies a role for the TES gene in endothelial cell functions relevant to coronary artery disease.
Archacki SR, Angheloiu G, Moravec CS, Liu H, Topol EJ, Wang QK. | 08/11/2012 |
| Alterations of TES mRNA level may predict the location of metastasis. CAV1 possibly affect the cancer cell invasion | Prognostic relevance of the expressions of CAV1 and TES genes on 7q31 in melanoma.
Vizkeleti L, Ecsedi S, Rakosy Z, Begany A, Emri G, Toth R, Orosz A, Szollosi AG, Mehes G, Adany R, Balazs M. | 05/19/2012 |
| These results suggest an interplay between the CaR and testin in the regulation of CaR-mediated Rho signalling with possible effects on the cytoskeleton. | Testin, a novel binding partner of the calcium-sensing receptor, enhances receptor-mediated Rho-kinase signalling.
Magno AL, Ingley E, Brown SJ, Conigrave AD, Ratajczak T, Ward BK. | 11/26/2011 |
| Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A. | Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A.
Boëda B, Knowles PP, Briggs DC, Murray-Rust J, Soriano E, Garvalov BK, McDonald NQ, Way M., Free PMC Article | 06/4/2011 |
| data implicate TES methylation in ALL and provide additional evidence for the involvement of LIM domain proteins in leukaemogenesis | Silencing of TESTIN by dense biallelic promoter methylation is the most common molecular event in childhood acute lymphoblastic leukaemia.
Weeks RJ, Kees UR, Song S, Morison IM., Free PMC Article | 12/11/2010 |
| results support the role of TES as a TSG in gastric carcinogenesis and that TES is inactivated primarily by LOH and CpG island methylation | Extensive analysis of D7S486 in primary gastric cancer supports TESTIN as a candidate tumor suppressor gene.
Ma H, Weng D, Chen Y, Huang W, Pan K, Wang H, Sun J, Wang Q, Zhou Z, Wang H, Xia J., Free PMC Article | 12/11/2010 |