| Results suggest that ELMOD2 is functioning as an effector downstream of ARL2 and upstream of the mitofusins to promote mitochondrial fusion. Data provide insights into the pathway by which mitochondrial fusion is regulated in the cell. | ELMOD2 regulates mitochondrial fusion in a mitofusin-dependent manner, downstream of ARL2.
Schiavon CR, Turn RE, Newman LE, Kahn RA., Free PMC Article | 09/14/2019 |
| The non-opioid sigma-1 receptor (S1R) was identified as a novel effector of GAP activity of ELMOD1-3 proteins as its direct binding to either ELMOD1 or ELMOD2 resulted in loss of GAP activity. | Characterization of recombinant ELMOD (cell engulfment and motility domain) proteins as GTPase-activating proteins (GAPs) for ARF family GTPases.
Ivanova AA, East MP, Yi SL, Kahn RA., Free PMC Article | 06/7/2014 |
| TLR3 pathway is dependent on ELMOD2 | ELMOD2, a candidate gene for idiopathic pulmonary fibrosis, regulates antiviral responses.
Pulkkinen V, Bruce S, Rintahaka J, Hodgson U, Laitinen T, Alenius H, Kinnula VL, Myllärniemi M, Matikainen S, Kere J. | 05/3/2010 |
| Results describe the purification from bovine testis of an Arl2 GAP and its identity as ELMOD2, a protein with no previously described function. | ELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs.
Bowzard JB, Cheng D, Peng J, Kahn RA. | 01/21/2010 |
| results suggest ELMOD2 as a novel candidate gene for susceptibility in familial idiopathic pulmonary fibrosis | ELMOD2 is a candidate gene for familial idiopathic pulmonary fibrosis.
Hodgson U, Pulkkinen V, Dixon M, Peyrard-Janvid M, Rehn M, Lahermo P, Ollikainen V, Salmenkivi K, Kinnula V, Kere J, Tukiainen P, Laitinen T., Free PMC Article | 01/21/2010 |