| Improvement of loperamide-induced slow transit constipation by Bifidobacterium bifidum G9-1 is mediated by the correction of butyrate production and neurotransmitter profile due to improvement in dysbiosis. | Improvement of loperamide-induced slow transit constipation by Bifidobacterium bifidum G9-1 is mediated by the correction of butyrate production and neurotransmitter profile due to improvement in dysbiosis.
Makizaki Y, Uemoto T, Yokota H, Yamamoto M, Tanaka Y, Ohno H., Free PMC Article | 10/16/2021 |
| Protein acetylation derepresses Serotonin Synthesis to potentiate Pancreatic Beta-Cell Function through HDAC1-PKA-Tph1 signaling. | Protein acetylation derepresses Serotonin Synthesis to potentiate Pancreatic Beta-Cell Function through HDAC1-PKA-Tph1 signaling.
Zhang Y, Wang S, Zhang L, Zhou F, Zhu K, Zhu Q, Liu Q, Liu Y, Jiang L, Ning G, Bi Y, Zhou L, Wang X., Free PMC Article | 05/8/2021 |
| tryptophan hydroxylase-1 (TPH1), an enzyme that catalyzes the reaction of Trp to serotonin, was significantly increased in liver and spleen of AT-2 engrafted rats. Further histochemical analysis revealed that the induction of TPH1 in the liver could be attributed to infiltration of mast cells. | Induction of tryptophan hydroxylase in the liver of s.c. tumor model of prostate cancer.
Hagiwara A, Nakamura Y, Nishimoto R, Ueno S, Miyagi Y., Free PMC Article | 04/25/2020 |
| The testes of control animals express the Tph1, Aanat, and Asmt and Per2 genes with 24-h rhythms in mRNA, reaching the maximal values during the dark phase. | The Absence of Pineal Melatonin Abolishes the Daily Rhythm of Tph1 (Tryptophan Hydroxylase 1), Asmt (Acetylserotonin O-Methyltransferase), and Aanat (Aralkylamine N-Acetyltransferase) mRNA Expressions in Rat Testes.
Coelho LA, Andrade-Silva J, Motta-Teixeira LC, Amaral FG, Reiter RJ, Cipolla-Neto J. | 03/14/2020 |
| Ursolic acid derivatives targeted to tryptophan hydroxylase 1 prevented bone loss by suppressing serotonin biosynthesis without estrogenic side-effects in ovariectomized rats. | Ursolic acid derivatives as bone anabolic agents targeted to tryptophan hydroxylase 1 (Tph-1).
Fu HJ, Zhao Y, Zhou YR, Bao BH, Du Y, Li JX. | 03/12/2016 |
| there exists possible interrelation between tyrosine hydroxylase and TPH gene expression and epigenetic histone acetylation in chronic unpredictable stress-induced depressive rats, which at least partly contributes to the etiology of depression. | Histone acetylation and expression of mono-aminergic transmitters synthetases involved in CUS-induced depressive rats.
Liu D, Qiu HM, Fei HZ, Hu XY, Xia HJ, Wang LJ, Qin LJ, Jiang XH, Zhou QX. | 05/17/2014 |
| An increased expression of TPH1 in the dorsal raphe nucleus may be the primary mechanism to explain the chronic increase in the brain synthesis of 5-HT in these in utero malnourished rats. | Increased expression of tryptophan-5-hydroxylase 1, but not 2, in brainstem as a result of intrauterine malnutrition.
Manjarrez-Gutiérrez G, Martínez-Radilla K, Boyzo-Montes de Oca A, Orozco-Suárez S, Hernández-Rodríguez J. | 02/9/2013 |
| Transfection of VMAT-1 and TPH-1 induced vesicular storage of serotonin which is triggered release upon cooling and has protective effects against hypothermia. | Induction of VMAT-1 and TPH-1 expression induces vesicular accumulation of serotonin and protects cells and tissue from cooling/rewarming injury.
Talaei F, Schmidt M, Henning RH., Free PMC Article | 06/2/2012 |
| data support the model that increased nocturnal 5-HT synthesis in the pineal gland is mediated by the phosphorylation of TPH1 at the serine 58, which elevates the TPH1 protein content and activity at night | Posttranslational regulation of TPH1 is responsible for the nightly surge of 5-HT output in the rat pineal gland.
Huang Z, Liu T, Chattoraj A, Ahmed S, Wang MM, Deng J, Sun X, Borjigin J., Free PMC Article | 01/21/2010 |
| TPH1 mRNA is 2.5-fold upregulated by the stress in dorsal raphe nucleus but not in pineal gland. | Stress upregulates TPH1 but not TPH2 mRNA in the rat dorsal raphe nucleus: identification of two TPH2 mRNA splice variants.
Abumaria N, Ribic A, Anacker C, Fuchs E, Flügge G. | 01/21/2010 |
| mRNA for TPH-1 was present in peripheral arteries, with low levels of TPH protein and TPH activity | The existence of a local 5-hydroxytryptaminergic system in peripheral arteries.
Ni W, Geddes TJ, Priestley JR, Szasz T, Kuhn DM, Watts SW., Free PMC Article | 01/21/2010 |
| Data showed that calcium influx blockaded by nifedipine caused a decrease in tryptophan hydroxylase activity. | Tryptophan hydroxylase is modulated by L-type calcium channels in the rat pineal gland.
Barbosa R, Scialfa JH, Terra IM, Cipolla-Neto J, Simonneaux V, Afeche SC. | 01/21/2010 |
| An adjacent GC-rich cis -acting sequence cooperates with the inverted CCAAT box for full activation of basal transcription; both elements are essential for full cAMP response. In pinealocytes, NF-Y and Sp1 bind the inverted CCAAT box and GC-rich-region | Involvement of NF-Y and Sp1 in basal and cAMP-stimulated transcriptional activation of the tryptophan hydroxylase (TPH ) gene in the pineal gland.
Côté F, Schussler N, Boularand S, Peirotes A, Thévenot E, Mallet J, Vodjdani G. | 01/21/2010 |
| This study reveals adrenal glucocorticoid-independent induction of tryptophan hydroxylase gene expression in raphe nuclei in response to immobilization stress. | Immobilization stress elevates tryptophan hydroxylase mRNA and protein in the rat raphe nuclei.
Chamas FM, Underwood MD, Arango V, Serova L, Kassir SA, Mann JJ, Sabban EL. | 01/21/2010 |
| regulation of rat tryptophan hydroxylase gene expression by stress involves 5' untranslated region | Role of the 5' untranslated region (UTR) in the tissue-specific regulation of rat tryptophan hydroxylase gene expression by stress.
Chamas F, Sabban EL. | 01/21/2010 |
| Tph1 and Tph2 transcripts showed robust diurnal rhythms of abundance, with highest levels at night. | Diurnal rhythms of tryptophan hydroxylase 1 and 2 mRNA expression in the rat retina.
Liang J, Wessel JH 3rd, Iuvone PM, Tosini G, Fukuhara C. | 01/21/2010 |
| TPH2 mRNA is expressed in raphe, in a pattern overlapping the histologically defined raphe nuclei. In sharp contrast, TPH1 (the previously known TPH) is expressed predominantly in pineal gland. | Robust and tissue-specific expression of TPH2 versus TPH1 in rat raphe and pineal gland.
Patel PD, Pontrello C, Burke S. | 01/21/2010 |
| Results show that the synthesis of 5-hydroxytryptamine and the expression of tryptophan hydroxylase in the dorsal raphe of rat offspring were suppressed by maternal ethanol intake. | Maternal ethanol administration inhibits 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of rat offspring.
Kim EK, Lee MH, Kim H, Sim YJ, Shin MS, Lee SJ, Yang HY, Chang HK, Lee TH, Jang MH, Shin MC, Lee HH, Kim CJ. | 01/21/2010 |
| TPH1 mRNA expression was 105-fold more abundant in rat pineal than TPH2; TPH2 expression within the gland showed no significant variation with time of day and was very low. | Comparison of circadian expression of tryptophan hydroxylase isoform mRNAs in the rat pineal gland using real-time PCR.
Sugden D. | 01/21/2010 |