| Data suggest underlying pathology for some patients with type II Bartter syndrome is linked to stability of ROMK1 in ERAD pathway; using a yeast expression system, cells can be rescued by wild-type (rat) ROMK1 but not by ROMK1 containing any one of four mutations found in (human) type II Bartter syndrome; mutant ROMKs are significantly less stable than wild-type ROMK. (ERAD = endoplasmic reticulum-associated degradation) | Endoplasmic reticulum-associated degradation of the renal potassium channel, ROMK, leads to type II Bartter syndrome.
O'Donnell BM, Mackie TD, Subramanya AR, Brodsky JL., Free PMC Article | 08/26/2017 |
| Blockade of ROMK or Na(+)-K(+)-2Cl(-) transport inhibits tubuloglomerular feedback yet increases renal vascular resistance. The renal vasoconstriction was independent of volume depletion, blood pressure, TGF, or proximal tubule hydrostatic pressure. | Inhibition of ROMK blocks macula densa tubuloglomerular feedback yet causes renal vasoconstriction in anesthetized rats.
Araujo M, Welch WJ, Zhou X, Sullivan K, Walsh S, Pasternak A, Wilcox CS. | 08/12/2017 |
| These preliminary findings suggest that K channel genes play a role in the development of secondary lymphedema | Potassium Channel Candidate Genes Predict the Development of Secondary Lymphedema Following Breast Cancer Surgery.
Smoot B, Kober KM, Paul SM, Levine JD, Abrams G, Mastick J, Topp K, Conley YP, Miaskowski CA., Free PMC Article | 06/3/2017 |
| Data indicate that mutations in kir1.1 potassium channel preferentially increase pH sensitivity. | State-dependent network connectivity determines gating in a K+ channel.
Bollepalli MK, Fowler PW, Rapedius M, Shang L, Sansom MS, Tucker SJ, Baukrowitz T., Free PMC Article | 05/16/2015 |
| The TPNQ toxin-rKir1.1 channel complex structure not only revealed their unique interaction mechanism, but also elucidate the relative insensitivity of rKir1.1 channel towards animal toxins. | Unique mechanism of the interaction between honey bee toxin TPNQ and rKir1.1 potassium channel explored by computational simulations: insights into the relative insensitivity of channel towards animal toxins.
Hu J, Qiu S, Yang F, Cao Z, Li W, Wu Y., Free PMC Article | 04/5/2014 |
| Heterozygous disruption of renal outer medullary potassium channel in rats is associated with reduced blood pressure. | Heterozygous disruption of renal outer medullary potassium channel in rats is associated with reduced blood pressure.
Zhou X, Zhang Z, Shin MK, Horwitz SB, Levorse JM, Zhu L, Sharif-Rodriguez W, Streltsov DY, Dajee M, Hernandez M, Pan Y, Urosevic-Price O, Wang L, Forrest G, Szeto D, Zhu Y, Cui Y, Michael B, Balogh LA, Welling PA, Wade JB, Roy S, Sullivan KA. | 10/19/2013 |
| Low luminal potassium inhibits the activity of ROMK channels in the kidney cortical collecting duct. | Inhibition of ROMK channels by low extracellular K+ and oxidative stress.
Frindt G, Li H, Sackin H, Palmer LG., Free PMC Article | 09/28/2013 |
| The findings support ROMK as the pore-forming subunit of the cytoprotective mitoK(ATP) channel in heart mitochondria. | Mitochondrial ROMK channel is a molecular component of mitoK(ATP).
Foster DB, Ho AS, Rucker J, Garlid AO, Chen L, Sidor A, Garlid KD, O'Rourke B., Free PMC Article | 10/20/2012 |
| Insulin also more than doubled ROMK (tertiapin-Q-sensitive) K(+) currents in kidney collecting ducts. | Effects of insulin on Na and K transporters in the rat CCD.
Frindt G, Palmer LG., Free PMC Article | 07/21/2012 |
| The large increase in the Rb/K conductance ratio, with no change in K/Na permeability or rectification, is consistent with R128Y-Kir1.1b causing a subtle change in the selectivity filter | A conserved arginine near the filter of Kir1.1 controls Rb/K selectivity.
Sackin H, Nanazashvili M, Li H, Palmer LG, Walters DE., Free PMC Article | 08/6/2011 |
| POSH inhibits ROMK channels by enhancing dynamin-dependent and clathrin-independent endocytosis and by stimulating ubiquitination of ROMK channels. | POSH stimulates the ubiquitination and the clathrin-independent endocytosis of ROMK1 channels.
Lin DH, Yue P, Pan CY, Sun P, Zhang X, Han Z, Roos M, Caplan M, Giebisch G, Wang WH., Free PMC Article | 01/21/2010 |
| Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho. | Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho.
Cha SK, Hu MC, Kurosu H, Kuro-o M, Moe O, Huang CL., Free PMC Article | 01/21/2010 |
| The Kir channel immunoglobulin domain is essential for Kir1.1 (ROMK) thermodynamic stability, trafficking and gating. | The Kir channel immunoglobulin domain is essential for Kir1.1 (ROMK) thermodynamic stability, trafficking and gating.
Fallen K, Banerjee S, Sheehan J, Addison D, Lewis LM, Meiler J, Denton JS., Free PMC Article | 01/21/2010 |
| Altered renal expression of ROMK in protein-deprived rats. | Altered renal expression of Na(+) transporters and ROMK in protein-deprived rats.
Ruete MC, Carrizo LC, Bocanegra MV, Vallés PG. | 01/21/2010 |
| hydrophobic leucines at the cytoplasmic end of the inner transmembrane helices comprise the principal pH gate of Kir1.1, a gate that can be relocated from 160-Kir1.1b to 157-Kir1.1b. | Moving the pH gate of the Kir1.1 inward rectifier channel.
Nanazashvili M, Li H, Palmer LG, Walters DE, Sackin H. | 01/21/2010 |
| May participate in the regulation of epithelial and smooth muscle cell volume and osmolality and in bidirectional potassium transport across urinary tract epithelia. | The ROMK potassium channel is present in mammalian urinary tract epithelia and muscle.
Spector DA, Yang Q, Klopouh L, Deng J, Weinman EJ, Steplock DA, Biswas R, Brazie MF, Liu J, Wade JB., Free PMC Article | 01/21/2010 |
| CD63 plays a role in the regulation of ROMK channels through its association with RPTPalpha, which in turn interacts with and activates Src family PTK, thus reducing ROMK activity. | Expression of tetraspan protein CD63 activates protein-tyrosine kinase (PTK) and enhances the PTK-induced inhibition of ROMK channels.
Lin D, Kamsteeg EJ, Zhang Y, Jin Y, Sterling H, Yue P, Roos M, Duffield A, Spencer J, Caplan M, Wang WH. | 01/21/2010 |
| Potassium restriction suppresses the expression of PP2B catalytic subunits and that inhibition of PP2B decreases ROMK channel activity. | K restriction inhibits protein phosphatase 2B (PP2B) and suppression of PP2B decreases ROMK channel activity in the CCD.
Zhang Y, Lin DH, Wang ZJ, Jin Y, Yang B, Wang WH., Free PMC Article | 01/21/2010 |
| ROMK is antagonistically regulated by long and kidney-specific WNK1 isoforms | Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms.
Lazrak A, Liu Z, Huang CL., Free PMC Article | 01/21/2010 |
| stimulation of PTK increases the ROMK channels in the intracellular compartment but decreases them in the apical/subapical membrane in the kidney cortex collecting duct | Protein tyrosine kinase is expressed and regulates ROMK1 location in the cortical collecting duct.
Lin DH, Sterling H, Yang B, Hebert SC, Giebisch G, Wang WH., Free PMC Article | 01/21/2010 |
| tyrosine phosphorylation of Kcnj is modulated by dietary K intake | K depletion increases protein tyrosine kinase-mediated phosphorylation of ROMK.
Lin DH, Sterling H, Lerea KM, Welling P, Jin L, Giebisch G, Wang WH., Free PMC Article | 01/21/2010 |
| Intrinsic sensitivity of Kir1.1 (ROMK) to glibenclamide in the absence of SUR2B. | Intrinsic sensitivity of Kir1.1 (ROMK) to glibenclamide in the absence of SUR2B. Implications for the identity of the renal ATP-regulated secretory K+ channel.
Konstas AA, Dabrowski M, Korbmacher C, Tucker SJ. | 01/21/2010 |
| structural analysis of the pH gate in the Kir1.1 inward rectifier channel | Structural locus of the pH gate in the Kir1.1 inward rectifier channel.
Sackin H, Nanazashvili M, Palmer LG, Krambis M, Walters DE., Free PMC Article | 01/21/2010 |
| the first 39 COOH-terminal amino acid residues form an ATP-PIP(2) binding domain in Kir1.1 and possibly the Kir6.x ATP-sensitive K(+) channels | Localization of the ATP/phosphatidylinositol 4,5 diphosphate-binding site to a 39-amino acid region of the carboxyl terminus of the ATP-regulated K+ channel Kir1.1.
Dong K, Tang L, MacGregor GG, Hebert SC. | 01/21/2010 |
| Most of investigated ROMK mutations displayed trafficking defect that might be rescued by pharmacologic agents acting as molecular chaperones. | Classification and rescue of ROMK mutations underlying hyperprostaglandin E syndrome/antenatal Bartter syndrome.
Peters M, Ermert S, Jeck N, Derst C, Pechmann U, Weber S, Schlingmann KP, Seyberth HW, Waldegger S, Konrad M. | 01/21/2010 |