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    FRK fyn related Src family tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 2444, updated on 21-Dec-2019

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Targetable fusions of the FRK tyrosine kinase in ALK-negative anaplastic large cell lymphoma.

    Targetable fusions of the FRK tyrosine kinase in ALK-negative anaplastic large cell lymphoma.
    Hu G, Dasari S, Asmann YW, Greipp PT, Knudson RA, Benson HK, Li Y, Eckloff BW, Jen J, Link BK, Jiang L, Sidhu JS, Wellik LE, Witzig TE, Bennani NN, Cerhan JR, Boddicker RL, Feldman AL., Free PMC Article

    04/18/2019
    our results present the first evidence that site-specific promoter methylation contributes to the repression of FRK more so in basal B breast cancers.

    Repression of Fyn-related kinase in breast cancer cells is associated with promoter site-specific CpG methylation.
    Bagu ET, Miah S, Dai C, Spriggs T, Ogunbolude Y, Beaton E, Sanders M, Goel RK, Bonham K, Lukong KE., Free PMC Article

    09/23/2017
    Loss of FRK protein may be implicated into the tumorigenesis and cell motility/invasiveness of human cervical cancer.

    Fyn-related kinase expression predicts favorable prognosis in patients with cervical cancer and suppresses malignant progression by regulating migration and invasion.
    Zhang X, Li F, Zhu PL.

    02/18/2017
    antagomir-1290 significantly inhibited the proliferation, clonogenicity, invasion, and migration of CD133(+) cells by targeting fyn-related Src family tyrosine kinase.

    Antagomir-1290 suppresses CD133⁺ cells in non-small cell lung cancer by targeting fyn-related Src family tyrosine kinase.
    Sun B, Yang N, Jiang Y, Zhang H, Hou C, Ji C, Liu Y, Zuo P.

    11/21/2015
    our results demonstrate a combined mechanism for the anti-proliferative effects of FRK by inhibiting cyclin D1 nucleus accumulation and pRb phosphorylation in glioma cells.

    FRK suppresses the proliferation of human glioma cells by inhibiting cyclin D1 nuclear accumulation.
    Hua L, Zhu M, Song X, Wang J, Fang Z, Zhang C, Shi Q, Zhan W, Wang L, Meng Q, Zhou X, Yu R.

    10/24/2015
    FRK over-expression promoted beta-catenin translocation to the plasma membrane, where it formed complex with N-cadherin.

    FRK inhibits migration and invasion of human glioma cells by promoting N-cadherin/β-catenin complex formation.
    Shi Q, Song X, Wang J, Gu J, Zhang W, Hu J, Zhou X, Yu R.

    09/12/2015
    exome sequencing identified recurrent somatic FRK mutations that induce constitutive kinase activity, STAT3 activation, and cell proliferation sensitive to Src inhibitors

    Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation.
    Pilati C, Letouzé E, Nault JC, Imbeaud S, Boulai A, Calderaro J, Poussin K, Franconi A, Couchy G, Morcrette G, Mallet M, Taouji S, Balabaud C, Terris B, Canal F, Paradis V, Scoazec JY, de Muret A, Guettier C, Bioulac-Sage P, Chevet E, Calvo F, Zucman-Rossi J.

    09/20/2014
    Data indicaate that the Rak/Frk SH2 and SH3 domains collaborate to increase the Rak-EGFR interaction.

    The Rak/Frk tyrosine kinase associates with and internalizes the epidermal growth factor receptor.
    Jin L, Craven RJ.

    03/15/2014
    The expression levels of FRK were significantly correlated with invasiveness in both Hep3B and HepG2 tumor cell lines.

    In silico identification of oncogenic potential of fyn-related kinase in hepatocellular carcinoma.
    Chen JS, Hung WS, Chan HH, Tsai SJ, Sun HS.

    08/31/2013
    these results clearly indicate that FRK may play a protective role against the progression of glioma by suppressing cell migration and invasion

    FRK controls migration and invasion of human glioma cells by regulating JNK/c-Jun signaling.
    Zhou X, Hua L, Zhang W, Zhu M, Shi Q, Li F, Zhang L, Song C, Yu R.

    04/27/2013
    Genetic variation near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.

    Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
    Yu Y, Bhangale TR, Fagerness J, Ripke S, Thorleifsson G, Tan PL, Souied EH, Richardson AJ, Merriam JE, Buitendijk GH, Reynolds R, Raychaudhuri S, Chin KA, Sobrin L, Evangelou E, Lee PH, Lee AY, Leveziel N, Zack DJ, Campochiaro B, Campochiaro P, Smith RT, Barile GR, Guymer RH, Hogg R, Chakravarthy U, Robman LD, Gustafsson O, Sigurdsson H, Ortmann W, Behrens TW, Stefansson K, Uitterlinden AG, van Duijn CM, Vingerling JR, Klaver CC, Allikmets R, Brantley MA Jr, Baird PN, Katsanis N, Thorsteinsdottir U, Ioannidis JP, Daly MJ, Graham RR, Seddon JM., Free PMC Article

    01/21/2012
    Study searched for mutations in the FRK gene, a recently identified tumor suppressor gene, for the first time in NSCLC. Somatic FRK mutations were found at a very low frequency in NSCLCs.

    Mutation analysis of the FRK gene in non-small cell lung cancers.
    Jin G, Jeon HS, Yang E, Park JY.

    04/2/2011
    Rak functions as a tumor suppressor by regulating PTEN protein stability and function in breast and bone neoplasms.

    Rak functions as a tumor suppressor by regulating PTEN protein stability and function.
    Yim EK, Peng G, Dai H, Hu R, Li K, Lu Y, Mills GB, Meric-Bernstam F, Hennessy BT, Craven RJ, Lin SY., Free PMC Article

    01/21/2010
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (2) articles

    Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
    Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A.

    No genetic association between polymorphisms in the Fyn kinase gene and age of schizophrenic onset.
    Ohnuma T, Shibata N, Matsubara Y, Sato S, Yamashina M, Arai H.

    03/13/2008
    Three common Japanese polymorphisms of the Fyn kinase gene studied in 127 healthy controls and 182 sporadic Alzheimer's disease failed to demonstrate any significant difference.

    No genetic association between Fyn kinase gene polymorphisms (-93A/G, IVS10+37T/C and Ex12+894T/G) and Japanese sporadic Alzheimer's disease.
    Watanabe T, Ohnuma T, Shibata N, Ohtsuka M, Ueki A, Nagao M, Arai H.

    01/21/2010
    Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase

    Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase.
    Meyer T, Xu L, Chang J, Liu ET, Craven RJ, Cance WG.

    01/21/2010
    The tyrosine kinases Brk/PTK6/Sik, Srm, Frk/Rak/Gtk/Iyk/Bsk, and Src42A/Dsrc41 have a low degree of sequence homology to other known kinases. The exon structure of these kinases, called the Brk family, is highly conserved and distinct.

    Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases.
    Serfas MS, Tyner AL.

    01/21/2010
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