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    Gfap glial fibrillary acidic protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24387, updated on 19-Apr-2019

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Results show that clustered regularly interspaced short palindromic repeats/Cas9-mediated SOX9 knockout not only inhibitedglial fibrillary acidic protein expression in rat Muller cells but also attenuated cell migration ability. These results suggest that inhibition of SOX9 activity may be a novel therapeutic strategy for reduction of glial cell activity.

    CRISPR-mediated SOX9 knockout inhibits GFAP expression in retinal glial (Müller) cells.
    Wang X, Shu Q, Ni Y, Xu G.

    02/16/2019
    demonstrate increased DNA methylation coupled with decreased histone acetylation at the Gfap promoter leading to suppression of Gfap expression under maternal hypothyroidism

    Mechanisms involved in epigenetic down-regulation of Gfap under maternal hypothyroidism.
    Kumar P, Godbole NM, Chaturvedi CP, Singh RS, George N, Upadhyay A, Anjum B, Godbole MM, Sinha RA.

    11/10/2018
    The present study found that social isolation during adolescence resulted in abnormal locomotor, emotional and cognitive behaviors and increased the expression of GFAP, ANXA2 and VIM in PFC of adult rats

    Adolescent social isolation affects schizophrenia-like behavior and astrocyte biomarkers in the PFC of adult rats.
    Sun L, Min L, Zhou H, Li M, Shao F, Wang W.

    04/21/2018
    GFAP-positive structures were present and exhibited a tendency to become linear on both sides, with an increased density on the left. NFAP-positive expression was present in the left treated limb with a disorganized pattern

    Adipose Tissue Graft Improves Early but not Late Stages of Nerve Regeneration.
    Bloancă V, Ceauşu AR, Jitariu AA, Barmayoun A, Moş R, Crăiniceanu Z, Bratu T., Free PMC Article

    03/31/2018
    We found that GFAP exhibited enhanced stability upon the addition of two equivalents of each ligands with ceftriaxone imparting a more spontaneous interactions and a more ordered complex system than phenytoin

    Interactions of GFAP with ceftriaxone and phenytoin: SRCD and molecular docking and dynamic simulation.
    Ruzza P, Vitale RM, Hussain R, Biondi B, Amodeo P, Sechi G, Siligardi G.

    11/4/2017
    reduction of GFAP+ cell density was in agreement with a lower expression of GFAP protein

    Anorexia Reduces GFAP+ Cell Density in the Rat Hippocampus.
    Reyes-Haro D, Labrada-Moncada FE, Varman DR, Krüger J, Morales T, Miledi R, Martínez-Torres A., Free PMC Article

    10/28/2017
    Astrocyte expression of GLAST/GFAP was reduced via JAK1/JAK2/STAT3 signaling pathway after exposure to sevoflurane.

    Sevoflurane Inhibits Glutamate-Aspartate Transporter and Glial Fibrillary Acidic Protein Expression in Hippocampal Astrocytes of Neonatal Rats Through the Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) Pathway.
    Wang W, Lu R, Feng DY, Zhang H.

    07/1/2017
    Upon ependymal stem cells differentiation, Cx50 expression favors glial cell fate, since higher expression levels, endogenous or by over-expression of Cx50, augmented the expression of the astrocyte marker GFAP and impaired the neuronal marker Tuj1.

    Connexin 50 Expression in Ependymal Stem Progenitor Cells after Spinal Cord Injury Activation.
    Rodriguez-Jimenez FJ, Alastrue-Agudo A, Stojkovic M, Erceg S, Moreno-Manzano V., Free PMC Article

    09/3/2016
    It is likely that a plastic change in GFAP expression in astrocytes selectively occurs around Oxytocin (OXT) neurons at proestrus and facilitates OXT release.

    Expression of glial fibrillary acidic protein in astrocytes of rat supraoptic nucleus throughout estrous cycle.
    Liu XY, Hou D, Wang J, Lv C, Jia S, Zhang Y, Wang R, Jin H, Zhu H, Wang YF.

    07/30/2016
    investigated temporal profile of astrocytic and neuronal injury markers after TBI; different mechanisms underlie clearance of UCH-L1 and GFAP in CSF and serum

    Acute Temporal Profiles of Serum Levels of UCH-L1 and GFAP and Relationships to Neuronal and Astroglial Pathology following Traumatic Brain Injury in Rats.
    Huang XJ, Glushakova O, Mondello S, Van K, Hayes RL, Lyeth BG.

    05/7/2016
    Its antibody is able to protect cells from oxidative stress, which is due to changed protein expressions of the actin cytoskeleton.

    GFAP antibodies show protective effect on oxidatively stressed neuroretinal cells via interaction with ERP57.
    Wilding C, Bell K, Funke S, Beck S, Pfeiffer N, Grus FH.

    04/9/2016
    GFAP release in hippocampus is significantly increased in a model of traumatic brain injury.

    S100B and Glial Fibrillary Acidic Protein as Indexes to Monitor Damage Severity in an In Vitro Model of Traumatic Brain Injury.
    Di Pietro V, Amorini AM, Lazzarino G, Yakoub KM, D'Urso S, Lazzarino G, Belli A.

    04/2/2016
    Hippocampal glucose uptake defects correlate with NeuN immunoreactivity in the latent phase and GFAP immunoreactivity in the chronic phase.

    FDG-PET and NeuN-GFAP immunohistochemistry of hippocampus at different phases of the pilocarpine model of temporal lobe epilepsy.
    Zhang L, Guo Y, Hu H, Wang J, Liu Z, Gao F., Free PMC Article

    11/14/2015
    paracrine factors inhibit p38 MAPK and JNK, and most likely by regulating their downstream targets, p53 and STAT1, to promote astrocyte survival associated with GFAP downregulation after ischemic stroke in vitro

    Paracrine Factors Secreted by MSCs Promote Astrocyte Survival Associated With GFAP Downregulation After Ischemic Stroke via p38 MAPK and JNK.
    Huang W, Lv B, Zeng H, Shi D, Liu Y, Chen F, Li F, Liu X, Zhu R, Yu L, Jiang X.

    09/26/2015
    The down-regulation of histone deacetylase SIRT1 abrogating the effect of cocoa on glial fibrillary acidic protein up-regulation and on Lys310-RelA/p65 acetylation by silencing or blockage was clearly demonstrated herein in vivo and in vitro.

    Polyphenol-enriched cocoa protects the diabetic retina from glial reaction through the sirtuin pathway.
    Duarte DA, Rosales MA, Papadimitriou A, Silva KC, Amancio VH, Mendonça JN, Lopes NP, de Faria JB, de Faria JM.

    09/5/2015
    Data indicate that glial fibrillary acidic protein (GFAP) was up-regulated in satellite glial cells (SGCs) in dorsal root ganglia 14 days after streptozotocin injection.

    Satellite glial cells in dorsal root ganglia are activated in streptozotocin-treated rodents.
    Hanani M, Blum E, Liu S, Peng L, Liang S., Free PMC Article

    08/29/2015
    increased in nucleus ambiguous after recurrent or superior laryngeal nerve injury

    GFAP immunoreactivity within the rat nucleus ambiguus after laryngeal nerve injury.
    Berdugo-Vega G, Arias-Gil G, Rodriguez-Niedenführ M, Davies DC, Vázquez T, Pascual-Font A., Free PMC Article

    07/4/2015
    Diametric expression of GFAP and a different morphological pattern of caspase-3 labelling, although no changes in the cell number, were observed in the neurons of young and old animals.

    Age-dependent modifications in vascular adhesion molecules and apoptosis after 48-h reperfusion in a rat global cerebral ischemia model.
    Anuncibay-Soto B, Pérez-Rodríguez D, Llorente IL, Regueiro-Purriños M, Gonzalo-Orden JM, Fernández-López A., Free PMC Article

    05/16/2015
    Fractionated gamma-irradiation with fixed total dose differently modified VEGF, GFAP, and BDNF gene expression in the brain tissue.

    Expression of VEGF, GFAP, and BDNF genes in the brain of rats after fractionated γ-irradiation according to different protocols.
    Zorkina YA, Yusubalieva GM, Koshkin FA, Chamorsov AY, Kistenev AV, Gorlachev GE, Golanov AV, Potapov AA, Chekhonin VP.

    04/25/2015
    Data indicate that histone demethylases KDM4A/C regulate H3K9 and H3K36 methylation on brain-derived neurotrophic factor (BDNF) versus astroglial glial fibrillary acidic protein (GFAP) genes in neural stem cells.

    Gene-specific methylation control of H3K9 and H3K36 on neurotrophic BDNF versus astroglial GFAP genes by KDM4A/C regulates neural stem cell differentiation.
    Cascante A, Klum S, Biswas M, Antolin-Fontes B, Barnabé-Heider F, Hermanson O.

    12/20/2014
    Progesterone promotes neuroprotection following traumatic brain injury by inhibiting the expression of Nogo-A and GFAP, and increasing GAP-43 expression.

    Progesterone alters Nogo-A, GFAP and GAP-43 expression in a rat model of traumatic brain injury.
    Liu F, Liao F, Li W, Han Y, Liao D.

    10/25/2014
    GFAP expression study also showed that cortical layer I usually contained multiple large astrocytes with branching processes, as well as numerous smaller processes with high intensity of expression.

    [Neuronal and glial antigen distribution in the columns of somatosensory cortex of rat brain (an immunohistochemical study)].
    Kirichenko EIu, Logvinov AK, Povilaĭtite PE, Grankina AO.

    10/18/2014
    GFAP repression is mediated through direct binding of p-PPARgamma (S112) to its promoter region.

    CDK5-induced p-PPARγ(Ser 112) downregulates GFAP via PPREs in developing rat brain: effect of metal mixture and troglitazone in astrocytes.
    Rai A, Tripathi S, Kushwaha R, Singh P, Srivastava P, Sanyal S, Bandyopadhyay S., Free PMC Article

    09/6/2014
    GFAP is an important marker in determining the severity of traumatic brain injury.

    Investigation of the course of GFAP in blood in the initial 24 hours in rats subjected to minor head trauma.
    Cikriklar HI, Ekici MA, Ozbek Z, Cosan DT, Baydemir C, Yürümez Y.

    03/29/2014
    To clarify whether GFAP-positive neoplastic astrocytes exist in rat spontaneous oligodendrogliomas and mixed gliomas or not, immunohistochemical examination was performed on spontaneous oligodendrogliomas (26 cases) and mixed gliomas.

    GFAP-positive neoplastic astrocytes in spontaneous oligodendrogliomas and mixed gliomas of rats.
    Nagatani M, Yamakawa S, Saito T, Ando R, Hoshiya T, Tamura K, Uchida K.

    11/2/2013
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