| The emergence of inflammatory microglia during gut inflammation is not affected by FFAR2 expression in intestinal epithelial cells or peripheral myeloid cells. | The emergence of inflammatory microglia during gut inflammation is not affected by FFAR2 expression in intestinal epithelial cells or peripheral myeloid cells.
Caetano-Silva ME, Rund L, Vailati-Riboni M, Matt S, Soto-Diaz K, Beever J, Allen JM, Woods JA, Steelman AJ, Johnson RW. | 04/12/2024 |
| GPR41 and GPR43 regulate CD8[+] T cell priming during herpes simplex virus type 1 infection. | GPR41 and GPR43 regulate CD8(+) T cell priming during herpes simplex virus type 1 infection.
Lee AR, Wilson KR, Clarke M, Engel S, Tscharke DC, Gebhardt T, Bedoui S, Bachem A., Free PMC Article | 03/27/2024 |
| FFAR2 expressing myeloid-derived suppressor cells drive cancer immunoevasion. | FFAR2 expressing myeloid-derived suppressor cells drive cancer immunoevasion.
Zhao Z, Qin J, Qian Y, Huang C, Liu X, Wang N, Li L, Chao Y, Tan B, Zhang N, Qian M, Li D, Liu M, Du B., Free PMC Article | 02/26/2024 |
| Intestinal FFA2 promotes obesity by altering food intake in Western diet-fed mice. | Intestinal FFA2 promotes obesity by altering food intake in Western diet-fed mice.
Lednovich KR, Gough S, Priyadarshini M, Pandya N, Nnyamah C, Xu K, Wicksteed B, Mishra S, Jain S, Zapater JL, Cordoba-Chacon J, Yadav H, Layden BT., Free PMC Article | 01/31/2024 |
| GPR43 stimulation on TCRalphabeta[+] intraepithelial colonic lymphocytes inhibits the recruitment of encephalitogenic T-cells into the central nervous system and attenuates the development of autoimmunity. | GPR43 stimulation on TCRαβ(+) intraepithelial colonic lymphocytes inhibits the recruitment of encephalitogenic T-cells into the central nervous system and attenuates the development of autoimmunity.
Prado C, Espinoza A, Martínez-Hernández JE, Petrosino J, Riquelme E, Martin AJM, Pacheco R., Free PMC Article | 06/7/2023 |
| Consumption of barley flour increases gut fermentation and improves glucose intolerance via the short-chain fatty acid receptor GPR43 in obese male mice. | Consumption of barley flour increases gut fermentation and improves glucose intolerance via the short-chain fatty acid receptor GPR43 in obese male mice.
Mio K, Iida-Tanaka N, Yamanaka C, Kimura I, Aoe S. | 01/28/2023 |
| Acetate, a metabolic product of Heligmosomoides polygyrus, facilitates intestinal epithelial barrier breakdown in a FFAR2-dependent manner. | Acetate, a metabolic product of Heligmosomoides polygyrus, facilitates intestinal epithelial barrier breakdown in a FFAR2-dependent manner.
Schälter F, Frech M, Dürholz K, Lucas S, Sarter K, Lebon L, Esser-von Bieren J, Dubey LK, Voehringer D, Schett G, Harris NL, Zaiss MM. | 10/15/2022 |
| Changes in gut microbiota, metabolite SCFAs, and GPR43 expression in obese diabetic mice after sleeve gastrectomy. | Changes in gut microbiota, metabolite SCFAs, and GPR43 expression in obese diabetic mice after sleeve gastrectomy.
Guo Y, Liu C, Zhao X, Zhang X, Wu Q, Wang Z, Lu J. | 08/13/2022 |
| GPR43 Suppresses Intestinal Tumor Growth by Modification of the Mammalian Target of Rapamycin Complex 1 Activity in ApcMin/+ Mice. | GPR43 Suppresses Intestinal Tumor Growth by Modification of the Mammalian Target of Rapamycin Complex 1 Activity in ApcMin/+ Mice.
Kong L, Hoshi N, Sui Y, Yamada Y, Yoshida R, Ooi M, Tian Z, Kimura I, Kodama Y., Free PMC Article | 04/30/2022 |
| Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior. | Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior.
Cook TM, Gavini CK, Jesse J, Aubert G, Gornick E, Bonomo R, Gautron L, Layden BT, Mansuy-Aubert V., Free PMC Article | 03/26/2022 |
| Acetate sensing by GPR43 alarms neutrophils and protects from severe sepsis. | Acetate sensing by GPR43 alarms neutrophils and protects from severe sepsis.
Schlatterer K, Beck C, Schoppmeier U, Peschel A, Kretschmer D., Free PMC Article | 11/13/2021 |
| GPR43 deficiency protects against podocyte insulin resistance in diabetic nephropathy through the restoration of AMPKalpha activity. | GPR43 deficiency protects against podocyte insulin resistance in diabetic nephropathy through the restoration of AMPKα activity.
Lu J, Chen PP, Zhang JX, Li XQ, Wang GH, Yuan BY, Huang SJ, Liu XQ, Jiang TT, Wang MY, Liu WT, Ruan XZ, Liu BC, Ma KL., Free PMC Article | 08/21/2021 |
| Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease. | Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease.
Kaye DM, Shihata WA, Jama HA, Tsyganov K, Ziemann M, Kiriazis H, Horlock D, Vijay A, Giam B, Vinh A, Johnson C, Fiedler A, Donner D, Snelson M, Coughlan MT, Phillips S, Du XJ, El-Osta A, Drummond G, Lambert GW, Spector TD, Valdes AM, Mackay CR, Marques FZ. | 04/3/2021 |
| Acetate protects against intestinal ischemia-reperfusion injury independent of its cognate free fatty acid 2 receptor. | Acetate protects against intestinal ischemia-reperfusion injury independent of its cognate free fatty acid 2 receptor.
Schofield ZV, Wu MCL, Hansbro PM, Cooper MA, Woodruff TM. | 03/6/2021 |
| Acetate coordinates neutrophil and ILC3 responses against C. difficile through FFAR2. | Acetate coordinates neutrophil and ILC3 responses against C. difficile through FFAR2.
Fachi JL, Sécca C, Rodrigues PB, Mato FCP, Di Luccia B, Felipe JS, Pral LP, Rungue M, Rocha VM, Sato FT, Sampaio U, Clerici MTPS, Rodrigues HG, Câmara NOS, Consonni SR, Vieira AT, Oliveira SC, Mackay CR, Layden BT, Bortoluci KR, Colonna M, Vinolo MAR., Free PMC Article | 10/31/2020 |
| Short-chain fatty acids bind to apoptosis-associated speck-like protein to activate inflammasome complex to prevent Salmonella infection. | Short-chain fatty acids bind to apoptosis-associated speck-like protein to activate inflammasome complex to prevent Salmonella infection.
Tsugawa H, Kabe Y, Kanai A, Sugiura Y, Hida S, Taniguchi S, Takahashi T, Matsui H, Yasukawa Z, Itou H, Takubo K, Suzuki H, Honda K, Handa H, Suematsu M., Free PMC Article | 10/24/2020 |
| Loss of Ffar2 promoted colon tumorigenesis in susceptible mice by reducing gut barrier integrity, increasing bacteria in tumors, promoting exhaustion of CD8+ T cells, and over-activating dendritic cells (DCs). DCs from ApcMin/+Ffar2-/- mice had an altered state of activation, increased death, and higher production of IL27. Antibodies against IL27 and agonists of Ffar2 reduced tumorigenesis in these mice. | Expression of Free Fatty Acid Receptor 2 by Dendritic Cells Prevents Their Expression of Interleukin 27 and Is Required for Maintenance of Mucosal Barrier and Immune Response Against Colorectal Tumors in Mice.
Lavoie S, Chun E, Bae S, Brennan CA, Gallini Comeau CA, Lang JK, Michaud M, Hoveyda HR, Fraser GL, Fuller MH, Layden BT, Glickman JN, Garrett WS., Free PMC Article | 07/11/2020 |
| findings demonstrate that the FFAR2 signaling cascade is important for the efficient endocytosis of IAV into host cells. | The G Protein-Coupled Receptor FFAR2 Promotes Internalization during Influenza A Virus Entry.
Wang G, Jiang L, Wang J, Zhang J, Kong F, Li Q, Yan Y, Huang S, Zhao Y, Liang L, Li J, Sun N, Hu Y, Shi W, Deng G, Chen P, Liu L, Zeng X, Tian G, Bu Z, Chen H, Li C., Free PMC Article | 06/13/2020 |
| Gpr43-deficient mice showed reduced weight loss and suppressed plasma lipoprotein lipase activity during fasting and eucaloric ketogenic diet feeding | Ketone body receptor GPR43 regulates lipid metabolism under ketogenic conditions.
Miyamoto J, Ohue-Kitano R, Mukouyama H, Nishida A, Watanabe K, Igarashi M, Irie J, Tsujimoto G, Satoh-Asahara N, Itoh H, Kimura I., Free PMC Article | 04/4/2020 |
| GPR43-/- mice exhibited decreased antibody responses and were more susceptible to Citrobacter rodentium infection | Microbiota Metabolite Short-Chain Fatty Acids Facilitate Mucosal Adjuvant Activity of Cholera Toxin through GPR43.
Yang W, Xiao Y, Huang X, Chen F, Sun M, Bilotta AJ, Xu L, Lu Y, Yao S, Zhao Q, Liu Z, Cong Y., Free PMC Article | 03/7/2020 |
| FFAR2 directly mediates both the stimulatory effects of Sodium acetate and Sodium propionate on insulin secretion and their protection against islet apoptosis. We have also shown that Short chain fatty acids coupling in islets occurs via Gq-coupled intracellular signaling. | Short chain fatty acids stimulate insulin secretion and reduce apoptosis in mouse and human islets in vitro: Role of free fatty acid receptor 2.
Pingitore A, Gonzalez-Abuin N, Ruz-Maldonado I, Huang GC, Frost G, Persaud SJ. | 09/14/2019 |
| single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias | A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias.
Sergeev E, Hansen AH, Bolognini D, Kawakami K, Kishi T, Aoki J, Ulven T, Inoue A, Hudson BD, Milligan G., Free PMC Article | 07/6/2019 |
| In conclusion, we report a previously unappreciated role of GPR43 in promoting host timely inflammation resolution of Gram-negative bacteria-induced lung injury. In addition, our study demonstrates that acetate-binding GPR43 can be critical for recovery from Klebsiella pneumoniae-induced lung injury by modulating neutrophils and macrophage activity. | The Metabolic Sensor GPR43 Receptor Plays a Role in the Control of Klebsiella pneumoniae Infection in the Lung.
Galvão I, Tavares LP, Corrêa RO, Fachi JL, Rocha VM, Rungue M, Garcia CC, Cassali G, Ferreira CM, Martins FS, Oliveira SC, Mackay CR, Teixeira MM, Vinolo MAR, Vieira AT., Free PMC Article | 03/9/2019 |
| results suggest that FFAR2 is an epigenetic tumor suppressor that acts at multiple stages of colon carcinogenesis | Loss of FFAR2 promotes colon cancer by epigenetic dysregulation of inflammation suppressors.
Pan P, Oshima K, Huang YW, Agle KA, Drobyski WR, Chen X, Zhang J, Yearsley MM, Yu J, Wang LS., Free PMC Article | 01/26/2019 |
| graft-versus-host disease protective effect of short-chain fatty acids requires GPR43-mediated ERK phosphorylation and activation of the NLRP3 inflammasome in non-hematopoietic target tissues of the host | Microbial metabolite sensor GPR43 controls severity of experimental GVHD.
Fujiwara H, Docampo MD, Riwes M, Peltier D, Toubai T, Henig I, Wu SJ, Kim S, Taylor A, Brabbs S, Liu C, Zajac C, Oravecz-Wilson K, Sun Y, Núñez G, Levine JE, van den Brink MRM, Ferrara JLM, Reddy P., Free PMC Article | 01/12/2019 |