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    NLRP1 NLR family pyrin domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 22861, updated on 7-Oct-2018

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    eight single nucleotide polymorphisms, four from NLRP1 (rs8079034, rs11651270, rs11657747, and rs878329) and NLRP3 (rs7512998, rs3806265, rs10754557, and rs10733113) each in 540 patients with Psoriasis Vulgaris and 612 healthy controls in the Chinese Han population, were genotyped.

    Association of <i>NLRP1</i> and <i>NLRP3</i> Polymorphisms with Psoriasis Vulgaris Risk in the Chinese Han Population.
    Yu P, Hao S, Zheng H, Zhao X, Li Y., Free PMC Article

    the analysis of multiple sclerosis (MS) patients from Canada failed to identify potentially pathogenic mutations in NLRP1, including the previously described p.G587S mutation. Further studies are necessary to confirm a role of NLRP1 in the pathophysiology of MS.

    Analysis of NOD-like receptor NLRP1 in multiple sclerosis families.
    Bernales CQ, Encarnacion M, Criscuoli MG, Yee IM, Traboulsee AL, Sadovnick AD, Vilariño-Güell C.

    Suggest inflammasome protein NLRP1 appears to have a specific role in the development of occlusive aortic disease.

    Differential mRNA expression of inflammasome genes NLRP1 and NLRP3 in abdominal aneurysmal and occlusive aortic disease.
    Gonzalez-Hidalgo C, De Haro J, Bleda S, Cañibano C, Michel I, Acin F., Free PMC Article

    Based on the data obtained from patients and in vitro cells, we concluded that both NLRP1 and NLRP3 inflammasomes are highly involved in the FLS inflammation and pyroptosis.

    NLRP1 and NLRP3 inflammasomes mediate LPS/ATP‑induced pyroptosis in knee osteoarthritis.
    Zhao LR, Xing RL, Wang PM, Zhang NS, Yin SJ, Li XC, Zhang L.

    NLRP1 promotes cell line MCF-7 the proliferation, migration, and invasion through inducing EMT.

    NLRP1 Overexpression Is Correlated with the Tumorigenesis and Proliferation of Human Breast Tumor.
    Wei Y, Huang H, Qiu Z, Li H, Tan J, Ren G, Wang X., Free PMC Article

    The changes in the nucleotide-binding oligomerization domain-like receptors (NLRs) in human corneas with disease expression may reflect different susceptibility to infectious and non-infectious injuries in corneas with various diseases.

    Transcription Profiling of NOD-like Receptors in the Human Cornea with Disease.
    Oh JY, Ko JH, Ryu JS, Lee HJ, Kim MK, Wee WR.

    The CC genotype of NLRP1 rs878329 and TT genotype of PADI4 rs2240340 were associated with Rheumatoid Arthritis susceptibility in Asians.

    NLRP1, PTPN22 and PADI4 gene polymorphisms and rheumatoid arthritis in ACPA-positive Singaporean Chinese.
    Goh LL, Yong MY, See WQ, Chee EYW, Lim PQ, Koh ET, Leong KP, TTSH RA Study Group..

    study results suggest variations in the inflammasome, particularly in NLRP1 and CARD11, may be associated with chronic Chagas cardiomyopathy

    Genetic association study of NLRP1, CARD, and CASP1 inflammasome genes with chronic Chagas cardiomyopathy among Trypanosoma cruzi seropositive patients in Bolivia.
    Clipman SJ, Henderson-Frost J, Fu KY, Bern C, Flores J, Gilman RH., Free PMC Article

    Data show that cyclic stretch activated the nucleotide-binding oligomerization domain-like receptor containing pyrin domain 1 and 3 (NLRP1 and NLRP3) inflammasomes and induced the release of IL-1beta and pyroptosis via a caspase-1-related mechanism in human periodontal ligament cells (HPDLCs).

    Activation of NLRP1 and NLRP3 inflammasomes contributed to cyclic stretch-induced pyroptosis and release of IL-1β in human periodontal ligament cells.
    Zhao D, Wu Y, Zhuang J, Xu C, Zhang F., Free PMC Article

    Our study demonstrated the potentially significant role of NLRP1 rs878329 (G>C) in developing susceptibility to the partial seizures in a Chinese Han population

    Association between NLPR1, NLPR3, and P2X7R Gene Polymorphisms with Partial Seizures.
    Wang H, Xu P, Liao D, Dang R, He X, Guo Y, Jiang P., Free PMC Article

    mRNA expression levels of NLRP1 and NLRC4 were not altered in chronic hepatitis B patients, suggesting that these genes are not responsible for the impaired immune responses against HBV observed in these patients.

    Evaluation of NLRC4, NLRP1, and NLRP3, as Components of Inflammasomes, in Chronic Hepatitis B Virus-Infected Patients.
    Askari A, Nosratabadi R, Khaleghinia M, Zainodini N, Kennedy D, Shabani Z, Kazemi Arababadi M.

    NLRP1 senses cellular infection by distinct invasive pathogens.

    Listeria monocytogenes and Shigella flexneri Activate the NLRP1B Inflammasome.
    Neiman-Zenevich J, Stuart S, Abdel-Nour M, Girardin SE, Mogridge J., Free PMC Article

    NLRP1 promotes melanoma growth by enhancing inflammasome activation and suppressing apoptotic pathways.

    NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma.
    Zhai Z, Liu W, Kaur M, Luo Y, Domenico J, Samson JM, Shellman YG, Norris DA, Dinarello CA, Spritz RA, Fujita M., Free PMC Article

    Two new mutations in NLRP1 (c.3641C>G, p.Pro1214Arg and c.2176C>T; p.Arg726Trp) were found to cause a new autoinflammatory syndrome, NLRP1-associated autoinflammation with arthritis and dyskeratosis.

    A new autoinflammatory and autoimmune syndrome associated with NLRP1 mutations: NAIAD (<i>NLRP1-</i>associated autoinflammation with arthritis and dyskeratosis).
    Grandemange S, Sanchez E, Louis-Plence P, Tran Mau-Them F, Bessis D, Coubes C, Frouin E, Seyger M, Girard M, Puechberty J, Costes V, Rodière M, Carbasse A, Jeziorski E, Portales P, Sarrabay G, Mondain M, Jorgensen C, Apparailly F, Hoppenreijs E, Touitou I, Geneviève D.

    Th17 micro-milieu via IL-17A regulates NLRP1-dependent CASP5 activity in psoriatic skin autoinflammation.

    Th17 micro-milieu regulates NLRP1-dependent caspase-5 activity in skin autoinflammation.
    Zwicker S, Hattinger E, Bureik D, Batycka-Baran A, Schmidt A, Gerber PA, Rothenfusser S, Gilliet M, Ruzicka T, Wolf R., Free PMC Article

    HO-1 inhibited expression of activating transcription factor 4 (ATF4), which is a transcription factor regulating NLRP1 expression

    Heme oxygenase-1 promotes neuron survival through down-regulation of neuronal NLRP1 expression after spinal cord injury.
    Lin WP, Xiong GP, Lin Q, Chen XW, Zhang LQ, Shi JX, Ke QF, Lin JH., Free PMC Article

    Simvastatin intake in peripheral arterial disease patients increases in vitro reactivity of NLRP1 inflammasome gene expression in endothelial cells.

    Effect of Simvastatin Treatment on "In Vitro" NLRP1 Inflammasome Expression in Peripheral Arterial Disease.
    Bleda S, de Haro J, Lopez de Maturana I, Varela C, Ferruelo A, Acin F.

    these findings establish a group of non-fever inflammasome disorders, uncover an unexpected auto-inhibitory function for the pyrin domain, and provide the first genetic evidence linking NLRP1 to skin inflammatory syndromes and skin cancer predisposition.

    Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation.
    Zhong FL, Mamaï O, Sborgi L, Boussofara L, Hopkins R, Robinson K, Szeverényi I, Takeichi T, Balaji R, Lau A, Tye H, Roy K, Bonnard C, Ahl PJ, Jones LA, Baker PJ, Lacina L, Otsuka A, Fournie PR, Malecaze F, Lane EB, Akiyama M, Kabashima K, Connolly JE, Masters SL, Soler VJ, Omar SS, McGrath JA, Nedelcu R, Gribaa M, Denguezli M, Saad A, Hiller S, Reversade B.

    The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer's disease

    The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer's disease.
    Saresella M, La Rosa F, Piancone F, Zoppis M, Marventano I, Calabrese E, Rainone V, Nemni R, Mancuso R, Clerici M., Free PMC Article

    NLRP1 inflammasome is activated by extracellular acidosis through ASIC1a signal pathway.

    Acid-sensing ion channel 1a contributes to the effect of extracellular acidosis on NLRP1 inflammasome activation in cortical neurons.
    Wang YC, Li WZ, Wu Y, Yin YY, Dong LY, Chen ZW, Wu WN., Free PMC Article

    Nlrp1 inflammasome is downregulated in trauma patients

    Nlrp1 inflammasome is downregulated in trauma patients.
    Relja B, Horstmann JP, Kontradowitz K, Jurida K, Schaible A, Neunaber C, Oppermann E, Marzi I.

    Human central Nervous System neurons express NLRP1 inflammasomes, which activate Casp1 and subsequently Casp6. Casp1 activation generates interleukin-1-beta-mediated neuroinflammation and Casp6 activation causes axonal degeneration.

    Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation.
    Kaushal V, Dye R, Pakavathkumar P, Foveau B, Flores J, Hyman B, Ghetti B, Koller BH, LeBlanc AC., Free PMC Article

    The data of this study suggested that NLRP1/caspase-1 signaling participates in the seizure-induced degenerative process in humans.

    NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model.
    Tan CC, Zhang JG, Tan MS, Chen H, Meng DW, Jiang T, Meng XF, Li Y, Sun Z, Li MM, Yu JT, Tan L., Free PMC Article

    The NLRP1 variant rs12150220 (L155H) was associated with the development of preeclampsia (OR = 1.58), suggesting a role of this inflammasome receptor in the pathogenesis of this multifactorial disorder.

    NLRP1 L155H Polymorphism is a Risk Factor for Preeclampsia Development.
    Pontillo A, Reis EC, Bricher PN, Vianna P, Diniz S, Fernandes KS, Chies JA, Sandrim V.

    Elevated expression of NLRP1 was associated with pemphigus vulgaris disease progression.

    Elevated expression of NLRP1 and IPAF are related to oral pemphigus vulgaris pathogenesis.
    Shamsabadi RM, Basafa S, Yarahmadi R, Goorani S, Khani M, Kamarehei M, Hossein Kiani A.

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