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    AAK1 AP2 associated kinase 1 [ Homo sapiens (human) ]

    Gene ID: 22848, updated on 15-Apr-2019

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Results present the first structures of AAK1 and BIKE which reveal that all members of the Numb-associated kinase family share unusual activation segment architecture.

    Family-wide Structural Analysis of Human Numb-Associated Protein Kinases.
    Sorrell FJ, Szklarz M, Abdul Azeez KR, Elkins JM, Knapp S., Free PMC Article

    12/17/2016
    Two of these kinases that were classified as resistors were PX domain-containing serine/threonine kinase (PXK) and AP2-associated kinase 1 (AAK1), which promote receptor endocytosis and may enable cells to resist TRAIL-induced apoptosis

    Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
    So J, Pasculescu A, Dai AY, Williton K, James A, Nguyen V, Creixell P, Schoof EM, Sinclair J, Barrios-Rodiles M, Gu J, Krizus A, Williams R, Olhovsky M, Dennis JW, Wrana JL, Linding R, Jorgensen C, Pawson T, Colwill K.

    01/2/2016
    AAK1 and GAK are critical regulators of HCV entry that function in part by activating EGFR, AP2M1, and NUMB, and as the molecular targets underlying the antiviral effect of sunitinib and erlotinib, respectively.

    AP-2-associated protein kinase 1 and cyclin G-associated kinase regulate hepatitis C virus entry and are potential drug targets.
    Neveu G, Ziv-Av A, Barouch-Bentov R, Berkerman E, Mulholland J, Einav S., Free PMC Article

    05/30/2015
    AAK1 increases the localization of activated Notch to Rab5-positive endocytic vesicles, while AAK1 depletion or overexpression of Numb, an inhibitor of the pathway, interferes with this localization.

    The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway.
    Gupta-Rossi N, Ortica S, Meas-Yedid V, Heuss S, Moretti J, Olivo-Marin JC, Israƫl A., Free PMC Article

    07/30/2011
    Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

    Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article

    06/30/2010
    Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)

    Genomewide association study for onset age in Parkinson disease.
    Latourelle JC, Pankratz N, Dumitriu A, Wilk JB, Goldwurm S, Pezzoli G, Mariani CB, DeStefano AL, Halter C, Gusella JF, Nichols WC, Myers RH, Foroud T, PROGENI Investigators, Coordinators and Molecular Genetic Laboratories., GenePD Investigators, Coordinators and Molecular Genetic Laboratories.., Free PMC Article

    12/2/2009
    These observations suggest that AAK1 functions at multiple steps of the endosomal pathway by regulating transferrin internalization and its rapid recycling back to the plasma membrane from early/sorting endosome.

    A novel AAK1 splice variant functions at multiple steps of the endocytic pathway.
    Henderson DM, Conner SD., Free PMC Article

    01/21/2010
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