| Loss of COPZ1 induces NCOA4 mediated autophagy and ferroptosis in glioblastoma cell lines. | Loss of COPZ1 induces NCOA4 mediated autophagy and ferroptosis in glioblastoma cell lines.
Zhang Y, Kong Y, Ma Y, Ni S, Wikerholmen T, Xi K, Zhao F, Zhao Z, Wang J, Huang B, Chen A, Yao Z, Han M, Feng Z, Hu Y, Thorsen F, Wang J, Li X., Free PMC Article | 07/31/2021 |
| siRNA-mediated COPZ1 depletion causes abortive autophagy, endoplasmic reticulum stress, unfolded protein response and apoptosis in thyroid tumor cells. | Targeting COPZ1 non-oncogene addiction counteracts the viability of thyroid tumor cells.
Anania MC, Cetti E, Lecis D, Todoerti K, Gulino A, Mauro G, Di Marco T, Cleris L, Pagliardini S, Manenti G, Belmonte B, Tripodo C, Neri A, Greco A. | 11/25/2017 |
| The knockdown of COPZ1, but not of COPZ2 encoding isoform coatomer protein complex zeta2, caused Golgi apparatus collapse, blocked autophagy, and induced apoptosis in both proliferating and nondividing tumor cells. | Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ΞΆ 2 renders tumor cells dependent on its paralogous gene COPZ1.
Shtutman M, Baig M, Levina E, Hurteau G, Lim CU, Broude E, Nikiforov M, Harkins TT, Carmack CS, Ding Y, Wieland F, Buttyan R, Roninson IB., Free PMC Article | 10/8/2011 |