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    VEGFD vascular endothelial growth factor D [ Homo sapiens (human) ]

    Gene ID: 2277, updated on 12-May-2019

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The RAISE biomarker program identified VEGF-D as a potential predictive biomarker for ramucirumab efficacy in second-line metastatic colorectal cancer treatment

    Analysis of angiogenesis biomarkers for ramucirumab efficacy in patients with metastatic colorectal cancer from RAISE, a global, randomized, double-blind, phase III study.
    Tabernero J, Hozak RR, Yoshino T, Cohn AL, Obermannova R, Bodoky G, Garcia-Carbonero R, Ciuleanu TE, Portnoy DC, Prausová J, Muro K, Siegel RW, Konrad RJ, Ouyang H, Melemed SA, Ferry D, Nasroulah F, Van Cutsem E., Free PMC Article

    SPARC expression was inversely associated with the degree of malignancy and it had a negative correlation with VEGF-C and VEGF-D expression. Results suggest SPARC might function as a tumor suppressor inhibiting angiogenesis and lymphangiogenesis in ovarian cancer by reducing the expression of VEGF-C and VEGF-D.

    SPARC suppresses lymph node metastasis by regulating the expression of VEGFs in ovarian carcinoma.
    Peng F, Zhong Y, Liu Y, Zhang Y, Xie Y, Lu Y, Zhang X, Li D.

    Serum VEGF-D levels were significantly increased in definite lymphangioleiomyomatosis (LAM) patients compared with healthy controls. Serum VEGF-D levels were significantly increased in definite LAM patients who had chylothorax compared with those without chylothorax.

    Diagnostic and Treatment Monitoring Potential of Serum Vascular Endothelial Growth Factor-D in Lymphangioleiomyomatosis.
    Mou Y, Ye L, Wang J, Yee MS, Song YL, Zhu L, Jin ML.

    no difference in the levels of VEGF-A, VEGF-C, and VEGF-D in pre-eclampsia compared to normotensive pregnant women stratified by HIV status

    Effect of vascular endothelial growth factors A, C, and D in HIV-associated pre-eclampsia.
    Shange GP, Moodley J, Naicker T.

    CXCR4, CCR7, VEGF-C and VEGF-D expression might have synergistic effects on the lymph node metastasis in patients with cervical cancer.

    Association of CXCR4, CCR7, VEGF-C and VEGF-D expression with lymph node metastasis in patients with cervical cancer.
    Dai Y, Tong R, Guo H, Yu T, Wang C.

    VEGF-D-induced changes in serine/threonine kinase mTOR shuttling between the cytosol and nucleus and its increased phosphorylation at Ser-2448, lead us to the conclusion that the observed shift in redox balance is regulated via mTOR kinase signalling.

    Vascular endothelial growth factor-D modulates oxidant-antioxidant balance of human vascular endothelial cells.
    Papiewska-Pająk I, Balcerczyk A, Stec-Martyna E, Koziołkiewicz W, Boncela J., Free PMC Article

    High VEGFD expression is associated with lymphangioleiomyomatosis.

    Aberrant SYK Kinase Signaling Is Essential for Tumorigenesis Induced by TSC2 Inactivation.
    Cui Y, Steagall WK, Lamattina AM, Pacheco-Rodriguez G, Stylianou M, Kidambi P, Stump B, Golzarri F, Rosas IO, Priolo C, Henske EP, Moss J, El-Chemaly S., Free PMC Article

    Data show that VEGF-C, VEGF-D, and VEGFR-3 were expressed in a substantial percentage of breast carcinomas.

    Vascular endothelial growth factor (VEGF)-C, VEGF-D, VEGFR-3 and D2-40 expressions in primary breast cancer: Association with lymph node metastasis.
    Eroğlu A, Ersöz C, Karasoy D, Sak S.

    High VEGFD expression is associated with angiogenesis and lymphangiogenesis.

    Differential Receptor Binding and Regulatory Mechanisms for the Lymphangiogenic Growth Factors Vascular Endothelial Growth Factor (VEGF)-C and -D.
    Davydova N, Harris NC, Roufail S, Paquet-Fifield S, Ishaq M, Streltsov VA, Williams SP, Karnezis T, Stacker SA, Achen MG., Free PMC Article

    VEGF-D and its receptors were co-localized on blood vessels in clinical samples of human lungs exposed to hyperoxia; hence, VEGF-D may act directly on blood vessels to promote fluid leak.

    VEGF-D promotes pulmonary oedema in hyperoxic acute lung injury.
    Sato T, Paquet-Fifield S, Harris NC, Roufail S, Turner DJ, Yuan Y, Zhang YF, Fox SB, Hibbs ML, Wilkinson-Berka JL, Williams RA, Stacker SA, Sly PD, Achen MG., Free PMC Article

    VEGF-D-enhanced metastasis was evidently reversed by MP. MP significantly reduced the invasion of VEGFD-SK cells, tumor volume, lymphatic metastasis rates and lymphatic vessel density compared with control groups

    VEGF-D-enhanced lymph node metastasis of ovarian cancer is reversed by vesicular stomatitis virus matrix protein.
    Qi X, Du L, Chen X, Chen L, Yi T, Chen X, Wen Y, Wei Y, Zhao X., Free PMC Article

    Sulf2 facilitated lymphangiogenesis in breast cancer cells by regulating VEGF-D and that the AKT1related signaling pathway was involved.

    Sulfatase 2 facilitates lymphangiogenesis in breast cancer by regulating VEGF-D.
    Zhu C, Qi X, Zhou X, Nie X, Gu Y., Free PMC Article

    Data indicate that vascular endothelial growth factor D (VEGF-D) was the best indicator of metastasis and vascular endothelial growth factors and receptor-3 (VEGFR-3) may help to determine the prognosis and management of colorectal cancer (CRC).

    Comparison of (18)F-fluorodeoxyglucose PET/CT findings with vascular endothelial growth factors and receptors in colorectal cancer.
    Kocael A, Vatankulu B, Şimşek O, Cengiz M, Kemik A, Kocael P, Halaç M, Sönmezoğlu K, Ulualp K.

    Taken together, our data suggest that TNF-alpha can promote lymphangiogenesis and lymphatic metastasis of GBC through the ERK1/2/AP-1/VEGF-D pathway.

    TNF-alpha promotes lymphangiogenesis and lymphatic metastasis of gallbladder cancer through the ERK1/2/AP-1/VEGF-D pathway.
    Hong H, Jiang L, Lin Y, He C, Zhu G, Du Q, Wang X, She F, Chen Y., Free PMC Article

    VEGF-D may play an important role in the process of lymphatic metastasis of epithelial ovarian cancer

    Expression of VEGF-D in epithelial ovarian cancer and its relationship to lymphatic metastasis.
    He L, He J, Zhao X.

    CCL21/CCR7 induce VEGF-D up-regulation and promote lymphangiogenesis via ERK/Akt pathway in lung cancer.

    CCL21/CCR7 up-regulate vascular endothelial growth factor-D expression via ERK pathway in human non-small cell lung cancer cells.
    Sun L, Zhang Q, Li Y, Tang N, Qiu X., Free PMC Article

    The most extensively accepted signaling pathways promoting lymphangiogenesis in tumors include the secreted lymphangiogenic proteins: VEGF-C and VEGF-D, and their cognate receptor on lymphatic endothelium VEGF receptor-3 (VEGFR-3).

    IGFBP7 functions as a potential lymphangiogenesis inducer in non-small cell lung carcinoma.
    Zhao W, Wang J, Zhu B, Duan Y, Chen F, Nian W, Sun J, Zhang B, Tong Z, Chen Z.

    Study demonstrated that VEGF-D upregulates myofibroblast proliferation, migration, and collagen synthesis through activation of VEGF pathway.

    Vascular endothelial growth factor-D mediates fibrogenic response in myofibroblasts.
    Zhao T, Zhao W, Meng W, Liu C, Chen Y, Bhattacharya SK, Sun Y.

    MTA1 is up-regulated in CRC; its expression is inversely associated with lymphatic metastases and the expression of VEGFC, VEGFD and VEGFR3

    MTA1 Is Up-regulated in Colorectal Cancer and Is Inversely Correlated with Lymphatic Metastasis.
    Li J, Ye L, Sun PH, Satherley L, Hargest R, Zhang Z, Jiang WG.

    VEGF-C/D score correlated neither with periphery Lymphatic vessel density (LVD) nor with LVD in the tumor center

    Expression of VEGF-C/-D and lymphangiogenesis in salivary adenoid cystic carcinoma.
    Stárek I, Salzman R, Kučerová L, Skálová A, Hauer L.

    study suggests that both VEGF-C and VEGF-D in tumor cells promote lymph node metastasis

    Significance of Vascular Endothelial Growth Factor (VEGF)-C and VEGF-D in the Progression of Cutaneous Melanoma.
    Špirić Z, Eri Ž, Erić M.

    A positive association for VEGF-D and an inverse association for MMP-2 were observed in patients with positive lymph node status at the time of radical cystectomy in urothelial carcinoma of the bladder.

    High VEGF-D and Low MMP-2 Serum Levels Predict Nodal-Positive Disease in Invasive Bladder Cancer.
    Benoit T, Keller EX, Wolfsgruber P, Hermanns T, Günthart M, Banzola I, Sulser T, Provenzano M, Poyet C., Free PMC Article

    These findings suggest that IL-8 may be a potent inducer of LECs, although this effect does not appear to involve the VEGF-C/VEGF-D and VEGFR-3 signaling pathway.

    Interleukin-8: A potent promoter of human lymphatic endothelial cell growth in gastric cancer.
    Shi J, Li YJ, Yan B, Wei PK., Free PMC Article

    fluid shear stress induces the synthesis of Insulin growth factor-2 and vascular endothelial growth factor (VEGF) B and D, which in turn transactivate MMP-12.

    Fluid shear promotes chondrosarcoma cell invasion by activating matrix metalloproteinase 12 via IGF-2 and VEGF signaling pathways.
    Wang P, Chen SH, Hung WC, Paul C, Zhu F, Guan PP, Huso DL, Kontrogianni-Konstantopoulos A, Konstantopoulos K., Free PMC Article

    Among VEGF homologs, MMPE from various kinds of tumor origin, VEGF-D showed 92.6% rate of positive expression. ICC stain of VEGF-D is a useful marker in the aid of MMPE diagnosis.

    VEGF-D as a marker in the aid of malignant metastatic pleural effusion diagnosis.
    Maa HC, Chao TT, Wang CY, Pei D, Liang YJ, Chen YL.

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