| The -KTS splice variant of WT1 is essential for ovarian determination in mice. | The -KTS splice variant of WT1 is essential for ovarian determination in mice.
Gregoire EP, De Cian MC, Migale R, Perea-Gomez A, Schaub S, Bellido-Carreras N, Stévant I, Mayère C, Neirijnck Y, Loubat A, Rivaud P, Sopena ML, Lachambre S, Linssen MM, Hohenstein P, Lovell-Badge R, Nef S, Chalmel F, Schedl A, Chaboissier MC., Free PMC Article | 03/15/2024 |
| Multigenerational paternal obesity enhances the susceptibility to male subfertility in offspring via Wt1 N6-methyladenosine modification. | Multigenerational paternal obesity enhances the susceptibility to male subfertility in offspring via Wt1 N6-methyladenosine modification.
Xiong YW, Zhu HL, Zhang J, Geng H, Tan LL, Zheng XM, Li H, Fan LL, Wang XR, Zhang XD, Wang KW, Chang W, Zhang YF, Yuan Z, Duan ZL, Cao YX, He XJ, Xu DX, Wang H., Free PMC Article | 02/21/2024 |
| WT1 regulates expression of DNA repair gene Neil3 during nephrogenesis. | WT1 regulates expression of DNA repair gene Neil3 during nephrogenesis.
Dickinson K, Hammond L, Akpa M, Chu LL, Lalonde CT, Goumba A, Goodyer P. | 02/24/2023 |
| The functions of Wt1 in mouse gonad development and somatic cells differentiationdagger. | The functions of Wt1 in mouse gonad development and somatic cells differentiation†.
Chen M, Cen C, Wang N, Shen Z, Wang M, Liu B, Li J, Cui X, Wang Y, Gao F. | 07/30/2022 |
| Deletion of Wt1 during early gonadogenesis leads to differences of sex development in male and female adult mice. | Deletion of Wt1 during early gonadogenesis leads to differences of sex development in male and female adult mice.
Torres-Cano A, Portella-Fortuny R, Müller-Sánchez C, Porras-Marfil S, Ramiro-Pareta M, Chau YY, Reina M, Soriano FX, Martínez-Estrada OM., Free PMC Article | 06/25/2022 |
| hnRNPU in Sertoli cells cooperates with WT1 and is essential for testicular development by modulating transcriptional factors Sox8/9. | hnRNPU in Sertoli cells cooperates with WT1 and is essential for testicular development by modulating transcriptional factors Sox8/9.
Wen Y, Ma X, Wang X, Wang F, Dong J, Wu Y, Lv C, Liu K, Zhang Y, Zhang Z, Yuan S., Free PMC Article | 02/12/2022 |
| Brain-specific Wt1 deletion leads to depressive-like behaviors in mice via the recruitment of Tet2 to modulate Epo expression. | Brain-specific Wt1 deletion leads to depressive-like behaviors in mice via the recruitment of Tet2 to modulate Epo expression.
Ji F, Wang W, Feng C, Gao F, Jiao J. | 01/29/2022 |
| Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice. | Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice.
Imeri F, Stepanovska Tanturovska B, Schwalm S, Saha S, Zeng-Brouwers J, Pavenstädt H, Pfeilschifter J, Schaefer L, Huwiler A. | 01/22/2022 |
| WT1 regulates HOXB9 gene expression in a bidirectional way. | WT1 regulates HOXB9 gene expression in a bidirectional way.
Schmidt V, Sieckmann T, Kirschner KM, Scholz H. | 01/1/2022 |
| Restricted differentiative capacity of Wt1-expressing peritoneal mesothelium in postnatal and adult mice. | Restricted differentiative capacity of Wt1-expressing peritoneal mesothelium in postnatal and adult mice.
Wilm TP, Tanton H, Mutter F, Foisor V, Middlehurst B, Ward K, Benameur T, Hastie N, Wilm B., Free PMC Article | 11/22/2021 |
| PRMT5 regulates ovarian follicle development by facilitating Wt1 translation. | PRMT5 regulates ovarian follicle development by facilitating Wt1 translation.
Chen M, Dong F, Chen M, Shen Z, Wu H, Cen C, Cui X, Bao S, Gao F., Free PMC Article | 11/13/2021 |
| The Inflammatory Process Modulates the Expression and Localization of WT1 in Podocytes Leading to Kidney Damage. | The Inflammatory Process Modulates the Expression and Localization of WT1 in Podocytes Leading to Kidney Damage.
Arellano-Rodríguez M, Zapata-Benavides P, Arellano-Rodríguez NC, Izaguirre-Álvarez JM, Franco-Molina MA, DE Jesús Torres Del Muro F, Mendoza-Gamboa E, Soto-Domínguez A, Saavedra-Alonso S, Rodríguez-Padilla C., Free PMC Article | 10/30/2021 |
| Defective mesothelium and limited physical space are drivers of dysregulated lung development in a genetic model of congenital diaphragmatic hernia. | Defective mesothelium and limited physical space are drivers of dysregulated lung development in a genetic model of congenital diaphragmatic hernia.
Gilbert RM, Schappell LE, Gleghorn JP., Free PMC Article | 10/9/2021 |
| Inactivation of Wt1 causes pre-granulosa cell to steroidogenic cell transformation and defect of ovary developmentdagger. | Inactivation of Wt1 causes pre-granulosa cell to steroidogenic cell transformation and defect of ovary development†.
Cen C, Chen M, Zhou J, Zhang L, Duo S, Jiang L, Hou X, Gao F. | 09/11/2021 |
| WT1 facilitates the self-renewal of leukemia-initiating cells through the upregulation of BCL2L2: WT1-BCL2L2 axis as a new acute myeloid leukemia therapy target. | WT1 facilitates the self-renewal of leukemia-initiating cells through the upregulation of BCL2L2: WT1-BCL2L2 axis as a new acute myeloid leukemia therapy target.
Zhou B, Jin X, Jin W, Huang X, Wu Y, Li H, Zhu W, Qin X, Ye H, Gao S., Free PMC Article | 06/26/2021 |
| MicroRNA-466o-3p mediates beta-catenin-induced podocyte injury by targeting Wilms tumor 1. | MicroRNA-466o-3p mediates β-catenin-induced podocyte injury by targeting Wilms tumor 1.
Chen Q, Chen J, Wang C, Chen X, Liu J, Zhou L, Liu Y. | 05/1/2021 |
| Reticular Fibroblasts Expressing the Transcription Factor WT1 Define a Stromal Niche that Maintains and Replenishes Splenic Red Pulp Macrophages. | Reticular Fibroblasts Expressing the Transcription Factor WT1 Define a Stromal Niche that Maintains and Replenishes Splenic Red Pulp Macrophages.
Bellomo A, Mondor I, Spinelli L, Lagueyrie M, Stewart BJ, Brouilly N, Malissen B, Clatworthy MR, Bajénoff M. | 03/27/2021 |
| Expansion of the renal capsular stroma, ureteric bud branching defects and cryptorchidism in mice with Wilms tumor 1 gene deletion in the stromal compartment of the developing kidney. | Expansion of the renal capsular stroma, ureteric bud branching defects and cryptorchidism in mice with Wilms tumor 1 gene deletion in the stromal compartment of the developing kidney.
Weiss AC, Rivera-Reyes R, Englert C, Kispert A. | 12/19/2020 |
| Testis formation in XX individuals resulting from novel pathogenic variants in Wilms' tumor 1 (WT1) gene. | Testis formation in XX individuals resulting from novel pathogenic variants in Wilms' tumor 1 (WT1) gene.
Eozenou C, Gonen N, Touzon MS, Jorgensen A, Yatsenko SA, Fusee L, Kamel AK, Gellen B, Guercio G, Singh P, Witchel S, Berman AJ, Mainpal R, Totonchi M, Mohseni Meybodi A, Askari M, Merel-Chali T, Bignon-Topalovic J, Migale R, Costanzo M, Marino R, Ramirez P, Perez Garrido N, Berensztein E, Mekkawy MK, Schimenti JC, Bertalan R, Mazen I, McElreavey K, Belgorosky A, Lovell-Badge R, Rajkovic A, Bashamboo A., Free PMC Article | 09/19/2020 |
| these results suggest that the B440 WT1 oral cancer vaccine can be developed as a novel oral immuno-oncology drug to treat castration-resistant prostate cancer as a monotherapy or as an adjunct to immune checkpoint inhibitors. | Preclinical Development of a WT1 Oral Cancer Vaccine Using a Bacterial Vector to Treat Castration-Resistant Prostate Cancer.
Kitagawa K, Gonoi R, Tatsumi M, Kadowaki M, Katayama T, Hashii Y, Fujisawa M, Shirakawa T. | 03/28/2020 |
| Our results show that the sustained presence of the WT1-BASP1 complex is required to maintain taste receptor cells in their differentiated | The WT1-BASP1 complex is required to maintain the differentiated state of taste receptor cells.
Gao Y, Dutta Banik D, Muna MM, Roberts SG, Medler KF., Free PMC Article | 01/25/2020 |
| WT1 deletion permits morphological transition of activated hepatic stellate cells to a myofibroblast phenotype and enhances fibrotic response in an in vivo model of pericentral liver fibrosis, defining WT1 as a paradoxical negative regulator of fibrogenic capacity during injury. | Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1.
Kendall TJ, Duff CM, Boulter L, Wilson DH, Freyer E, Aitken S, Forbes SJ, Iredale JP, Hastie ND., Free PMC Article | 01/18/2020 |
| Study shows that WT1 functions as a positive regulator of fibroblast activation, including fibroproliferation, myofibroblast transformation, and extracellular matrix production. WT1 binds directly to the promoter DNA sequence of alpha-smooth muscle actin to induce myofibroblast transformation. Importantly, the partial loss of WT1 was sufficient to attenuate myofibroblast accumulation and pulmonary fibrosis in vivo. | Wilms' tumor 1 drives fibroproliferation and myofibroblast transformation in severe fibrotic lung disease.
Sontake V, Kasam RK, Sinner D, Korfhagen TR, Reddy GB, White ES, Jegga AG, Madala SK., Free PMC Article | 12/14/2019 |
| Wt1(+) mesothelial and fibroblastic stromal cells constitute essential niche components supporting the tissue-specifying transcriptional landscape and homeostasis of cavity-resident macrophages. | A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages.
Buechler MB, Kim KW, Onufer EJ, Williams JW, Little CC, Dominguez CX, Li Q, Sandoval W, Cooper JE, Harris CA, Junttila MR, Randolph GJ, Turley SJ., Free PMC Article | 12/14/2019 |
| Wt1 activates Srpk1 and Srsf1 and induces expression of angiogenic VEGF isoforms in tumor endothelium. | Altered VEGF Splicing Isoform Balance in Tumor Endothelium Involves Activation of Splicing Factors Srpk1 and Srsf1 by the Wilms' Tumor Suppressor Wt1.
Wagner KD, El Maï M, Ladomery M, Belali T, Leccia N, Michiels JF, Wagner N., Free PMC Article | 12/14/2019 |