| ORAOV1, CCND1, and MIR548K Are the Driver Oncogenes of the 11q13 Amplicon in Squamous Cell Carcinoma. | ORAOV1, CCND1, and MIR548K Are the Driver Oncogenes of the 11q13 Amplicon in Squamous Cell Carcinoma.
Mahieu CI, Mancini AG, Vikram EP, Planells-Palop V, Joseph NM, Tward AD., Free PMC Article | 02/7/2024 |
| ORAOV1-B Promotes OSCC Metastasis via the NF-kappaB-TNFalpha Loop. | ORAOV1-B Promotes OSCC Metastasis via the NF-κB-TNFα Loop.
Luo X, Jiang Y, Chen F, Wei Z, Qiu Y, Xu H, Tian G, Gong W, Yuan Y, Feng H, Zhong L, Ji N, Xu X, Sun C, Li T, Li J, Feng X, Deng P, Zeng X, Zhou M, Zhou Y, Dan H, Jiang L, Chen Q. | 08/14/2021 |
| Validation of ORAOV1 as a new treatment target in hepatocellular carcinoma. | Validation of ORAOV1 as a new treatment target in hepatocellular carcinoma.
Ha SY, Yeo SY, Lee KW, Kim SH. | 02/6/2021 |
| provides the first evidence of ORAOV1 overexpression in esophageal squamous cell cancer and esophageal squamous intraepithelial neoplasia | ORAOV1 overexpression in esophageal squamous cell carcinoma and esophageal dysplasia: a possible biomarker of progression and poor prognosis in esophageal carcinoma.
Li M, Cui X, Shen Y, Dong H, Liang W, Chen Y, Hu J, Li S, Kong J, Li H, Zhao J, Li F. | 06/20/2015 |
| the ORAOV1 gene is frequently amplified in esophageal squamous cell cancer | Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production.
Togashi Y, Arao T, Kato H, Matsumoto K, Terashima M, Hayashi H, de Velasco MA, Fujita Y, Kimura H, Yasuda T, Shiozaki H, Nishio K., Free PMC Article | 01/24/2015 |
| The ORAOV1 complex could prevent ROS-induced ribosomal damage, explaining why overexpression of ORAOV1 is so common in solid tumours | The function of ORAOV1/LTO1, a gene that is overexpressed frequently in cancer: essential roles in the function and biogenesis of the ribosome.
Zhai C, Li Y, Mascarenhas C, Lin Q, Li K, Vyrides I, Grant CM, Panaretou B. | 03/15/2014 |
| overexpression of ORAOV1 in non-tumoral margin samples can occur in absence of amplification. weak correlation between ORAOV1 amplification and expression in OSSC suggests ORAOV1 expression can be regulated by mechanisms other than gene amplification. | ORAOV1 is amplified in oral squamous cell carcinoma.
Xavier FC, Rodini CO, Paiva KB, Destro MF, Severino P, Moyses RA, Head and Neck Genome Project GENCAPO, Tajara EH, Nunes FD. | 06/23/2012 |
| An oral cancer overexpressed 1 (ORAOV1) gene was identified as a probable target within the 11q13 amplicon in lymph node metastases from gastric adenocarcinoma. | ORAOV1 is a probable target within the 11q13.3 amplicon in lymph node metastases from gastric adenocarcinoma.
Kang JU, Koo SH. | 05/12/2012 |
| ORAOV1 has an important role in regulating cell growth of cervical cancer HeLa cells through regulating the cell cycle and apoptosis. | Oral cancer overexpressed 1 (ORAOV1) regulates cell cycle and apoptosis in cervical cancer HeLa cells.
Jiang L, Zeng X, Wang Z, Ji N, Zhou Y, Liu X, Chen Q., Free PMC Article | 05/31/2010 |
| In OSCC tissue samples, the expression frequency of ORAOV1-A (51.1%) was much higher than that in normal samples (10.5%). ORAOV1-A may play a functional role in the tumorigenesis of OSCC. | ORAOV1-A correlates with poor differentiation in oral cancer.
Jiang L, Yang HS, Wang Z, Zhou Y, Zhou M, Zeng X, Chen QM. | 01/21/2010 |
| ORAOV1 plays pivotal roles in the growth and angiogenesis of oral squamous cell carcinoma. | Oral cancer overexpressed 1 (ORAOV1): a regulator for the cell growth and tumor angiogenesis in oral squamous cell carcinoma.
Jiang L, Zeng X, Yang H, Wang Z, Shen J, Bai J, Zhang Y, Gao F, Zhou M, Chen Q. | 01/21/2010 |
| data suggested potential roles in oral carcinogenesis and that TAOS1 might be involved earlier than EMS1. Both genes might be candidate biomarkers for diagnosis and prognosis in OSCC | Amplifications of TAOS1 and EMS1 genes in oral carcinogenesis: association with clinicopathological features.
Xia J, Chen Q, Li B, Zeng X. | 01/21/2010 |
| High-resolution mapping of the 11q13 amplicon and identification of a gene that is amplified and overexpressed in oral cancer cells | High-resolution mapping of the 11q13 amplicon and identification of a gene, TAOS1, that is amplified and overexpressed in oral cancer cells.
Huang X, Gollin SM, Raja S, Godfrey TE., Free PMC Article | 01/21/2010 |