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    Tcf3 transcription factor 3 [ Mus musculus (house mouse) ]

    Gene ID: 21423, updated on 4-Jun-2017

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Data suggest a novel mechanism of drug resistance in which E2a and PRC2 drive changes in the B-cell epigenome; these alterations attenuate alkylating agent treatment-induced apoptosis.

    Epigenetic changes mediated by polycomb repressive complex 2 and E2a are associated with drug resistance in a mouse model of lymphoma.
    Flinders C, Lam L, Rubbi L, Ferrari R, Fitz-Gibbon S, Chen PY, Thompson M, Christofk H, B Agus D, Ruderman D, Mallick P, Pellegrini M., Free PMC Article

    These findings suggest that miR-506-3p played an important role in regulating NSC proliferation and differentiation via targeting TCF3, and provide a promising avenue for future in-depth research into the functions of miR-506-3p and TCF3 in nervous system development.

    MicroRNA-506-3p regulates neural stem cell proliferation and differentiation through targeting TCF3.
    Wang Y, Jiaqi C, Zhaoying C, Huimin C.

    Conditional expression of E2A-HLF induces B-cell precursor death and myeloproliferative-like disease in knock-in mice.

    Conditional Expression of E2A-HLF Induces B-Cell Precursor Death and Myeloproliferative-Like Disease in Knock-In Mice.
    Duque-Afonso J, Smith KS, Cleary ML., Free PMC Article

    Upregulation of E12/E47 by HBx ultimately and concomitant repression of E-cadherin expression led to epithelial-mesenchymal transition in human hepatocytes.

    Hepatitis B virus X protein induces epithelial-mesenchymal transition by repressing E-cadherin expression via upregulation of E12/E47.
    Shin Kim S, Yeom S, Kwak J, Ahn HJ, Lib Jang K.

    Mechanistically, E47 repressed the expression of several astrocyte-specific genes in adult NSPCs.

    The balance of Id3 and E47 determines neural stem/precursor cell differentiation into astrocytes.
    Bohrer C, Pfurr S, Mammadzada K, Schildge S, Plappert L, Hils M, Pous L, Rauch KS, Dumit VI, Pfeifer D, Dengjel J, Kirsch M, Schachtrup K, Schachtrup C., Free PMC Article

    Tcf3 is upregulated in skin wounds and Tcf3 overexpression accelerates keratinocyte migration and skin wound healing.

    Tcf3 promotes cell migration and wound repair through regulation of lipocalin 2.
    Miao Q, Ku AT, Nishino Y, Howard JM, Rao AS, Shaver TM, Garcia GE, Le DN, Karlin KL, Westbrook TF, Poli V, Nguyen H., Free PMC Article

    Loss and gain of function analyses combined with in vivo studies in syngeneic breast cancer models demonstrate the participation of LOXL2 and E47 in tumor growth and their requirement for lung metastasis.

    Lysyl oxidase-like 2 (LOXL2) and E47 EMT factor: novel partners in E-cadherin repression and early metastasis colonization.
    Canesin G, Cuevas EP, Santos V, López-Menéndez C, Moreno-Bueno G, Huang Y, Csiszar K, Portillo F, Peinado H, Lyden D, Cano A.

    constitutive expression distinguishes tumor-resident monocyte-derived myeloid suppressor cells

    Myeloid-derived suppressor activity is mediated by monocytic lineages maintained by continuous inhibition of extrinsic and intrinsic death pathways.
    Haverkamp JM, Smith AM, Weinlich R, Dillon CP, Qualls JE, Neale G, Koss B, Kim Y, Bronte V, Herold MJ, Green DR, Opferman JT, Murray PJ., Free PMC Article

    Tcf3 has a role in repressing Wnt-beta-catenin signaling and maintaining neural stem cell population during neocortical development

    Tcf3 represses Wnt-β-catenin signaling and maintains neural stem cell population during neocortical development.
    Kuwahara A, Sakai H, Xu Y, Itoh Y, Hirabayashi Y, Gotoh Y., Free PMC Article

    Transcription of RORgammat in developing Th17 cells is regulated by E-proteins.

    Transcription of RORγt in developing Th17 cells is regulated by E-proteins.
    Zhang F, Fuss IJ, Yang Z, Strober W., Free PMC Article

    the role of Tcf3 in cell-fate decision is more complex than previously appreciated and is highly dependent on cellular context

    Tcf3 expression marks both stem and progenitor cells in multiple epithelia.
    Howard JM, Nuguid JM, Ngole D, Nguyen H., Free PMC Article

    Id2 represses E2A-mediated activation of IL-10 expression in T cells.

    Id2 represses E2A-mediated activation of IL-10 expression in T cells.
    Masson F, Ghisi M, Groom JR, Kallies A, Seillet C, Johnstone RW, Nutt SL, Belz GT.

    transcription factor E2A binds to the UNG2 promoter and represses UNG2 expression.

    Expression and recruitment of uracil-DNA glycosylase are regulated by E2A during antibody diversification.
    Wallenius A, Hauser J, Aas PA, Sarno A, Kavli B, Krokan HE, Grundström T.

    pre-BCR signaling downregulates several components of the recombination machinery, including RAG1, RAG2, and PAX5, through calmodulin inhibition of E2A.

    Allelic exclusion of IgH through inhibition of E2A in a VDJ recombination complex.
    Hauser J, Grundström C, Grundström T.

    NF-kappaB potentiated the binding of E2A to an E-box motif located immediately downstream of the 2 closely-spaced transcription start sites for sustained 14-3-3gamma expression and CSR induction.

    Induction of activation-induced cytidine deaminase-targeting adaptor 14-3-3γ is mediated by NF-κB-dependent recruitment of CFP1 to the 5'-CpG-3'-rich 14-3-3γ promoter and is sustained by E2A.
    Mai T, Pone EJ, Li G, Lam TS, Moehlman J, Xu Z, Casali P., Free PMC Article

    Cell-intrinsic in vivo requirement for the E47-p21 pathway in long-term hematopoietic stem cells.

    Cell-intrinsic in vivo requirement for the E47-p21 pathway in long-term hematopoietic stem cells.
    Santos PM, Ding Y, Borghesi L., Free PMC Article

    Id2 restrains CD8(+) T cell memory differentiation by inhibiting E2A-mediated direct activation of Tcf7 and that Id2 expression.

    Id2-mediated inhibition of E2A represses memory CD8+ T cell differentiation.
    Masson F, Minnich M, Olshansky M, Bilic I, Mount AM, Kallies A, Speed TP, Busslinger M, Nutt SL, Belz GT., Free PMC Article

    Wnt signaling down-regulates Tcf3 expression, possibly at both the transcriptional and post-transcriptional levels.. it is a novel mechanism through which Wnt signaling inhibits neuro-ectodermal lineage differentiation

    Wnt signaling regulates the lineage differentiation potential of mouse embryonic stem cells through Tcf3 down-regulation.
    Atlasi Y, Noori R, Gaspar C, Franken P, Sacchetti A, Rafati H, Mahmoudi T, Decraene C, Calin GA, Merrill BJ, Fodde R., Free PMC Article

    E2A transcription factors limit expression of Gata3 to facilitate T lymphocyte lineage commitment.

    E2A transcription factors limit expression of Gata3 to facilitate T lymphocyte lineage commitment.
    Xu W, Carr T, Ramirez K, McGregor S, Sigvardsson M, Kee BL., Free PMC Article

    Protein inhibitor of activated STAT, PIASy regulates alpha-smooth muscle actin expression by interacting with E12 in mesangial cells.

    Protein inhibitor of activated STAT, PIASy regulates α-smooth muscle actin expression by interacting with E12 in mesangial cells.
    Torikoshi K, Abe H, Matsubara T, Hirano T, Ohshima T, Murakami T, Araki M, Mima A, Iehara N, Fukatsu A, Kita T, Arai H, Doi T., Free PMC Article

    Deficiency in the E proteins, E2A and HEB, led to increased frequency of terminally differentiated effector KLRG1(hi) CD8(+) T cells in mice during infection, and decreased generation of longer-lived memory-precursor cells during the immune response.

    Loss of E protein transcription factors E2A and HEB delays memory-precursor formation during the CD8+ T-cell immune response.
    D'Cruz LM, Lind KC, Wu BB, Fujimoto JK, Goldrath AW., Free PMC Article

    A direct physical interaction between beta-catenin and Tcf3 in the nucleus was confirmed by co-immunoprecipitation studies. and the inhibitory beta-catenin/Tcf3 interface was independent of the ability of Tcf3 to directly interact with DNA.

    Mouse Tcf3 represses canonical Wnt signaling by either competing for β-catenin binding or through occupation of DNA-binding sites.
    Solberg N, Machon O, Machonova O, Krauss S.

    These results thus implicate the E2A-CDKN1A transcriptional axis in the control of megakaryopoiesis and reveal the lineage-selective inhibition of this axis as a likely mechanistic basis for the inhibitory effects of cAMP signaling.

    Cyclic AMP signaling inhibits megakaryocytic differentiation by targeting transcription factor 3 (E2A) cyclin-dependent kinase inhibitor 1A (CDKN1A) transcriptional axis.
    Rubinstein JD, Elagib KE, Goldfarb AN., Free PMC Article

    the feedback inhibition of the BCR signalosome is to a large extent through inhibition of the transcription factor E2A by Ca(2+)/calmodulin

    Negative feedback regulation of antigen receptors through calmodulin inhibition of E2A.
    Verma-Gaur J, Hauser J, Grundström T.

    Wnt/beta-catenin counteracts Tcf3 repression of Lef1, which subsequently activates target gene expression via Lef1-beta-catenin complexes.

    Function of Wnt/β-catenin in counteracting Tcf3 repression through the Tcf3-β-catenin interaction.
    Wu CI, Hoffman JA, Shy BR, Ford EM, Fuchs E, Nguyen H, Merrill BJ., Free PMC Article

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