NME3 binds to phosphatidic acid and mediates PLD6-induced mitochondrial tethering. | NME3 binds to phosphatidic acid and mediates PLD6-induced mitochondrial tethering. Su YA, Chiu HY, Chang YC, Sung CJ, Chen CW, Tei R, Huang XR, Hsu SC, Lin SS, Wang HC, Lin YC, Hsu JC, Bauer H, Feng Y, Baskin JM, Chang ZF, Liu YW., Free PMC Article | 08/17/2023 |
Decreased piRNAs in Infertile Semen Are Related to Downregulation of Sperm MitoPLD Expression. | Decreased piRNAs in Infertile Semen Are Related to Downregulation of Sperm MitoPLD Expression. Hong Y, Wu Y, Zhang J, Yu C, Shen L, Chen H, Chen L, Zhou X, Gao F., Free PMC Article | 02/19/2022 |
Propose that MIGA proteins promote mitochondrial fusion by regulating mitochondrial phospholipid metabolism via MitoPLD. | Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis. Zhang Y, Liu X, Bai J, Tian X, Zhao X, Liu W, Duan X, Shang W, Fan HY, Tong C. | 05/28/2016 |
MitoPLD performs a critical function in a pathway that creates a specialized form of RNAi required by developing spermatocytes to suppress transposon mobilization during meiosis. | Roles for the lipid-signaling enzyme MitoPLD in mitochondrial dynamics, piRNA biogenesis, and spermatogenesis. Gao Q, Frohman MA., Free PMC Article | 07/7/2012 |
Data suggest that mitochondrial-surface phosphatidic acid generated by MitoPLD/Zuc recruits or activates nuage components critical for piRNA production. | piRNA-associated germline nuage formation and spermatogenesis require MitoPLD profusogenic mitochondrial-surface lipid signaling. Huang H, Gao Q, Peng X, Choi SY, Sarma K, Ren H, Morris AJ, Frohman MA., Free PMC Article | 05/14/2011 |
PLD6, aka MitoPLD, encodes an N-terminal mitochondrial localization sequence, localizes to the outer mitochondrial surface, generates phosphatidic acid, a signaling lipid, and triggers trans-mitochondrial association; involved in mitochondrial fusion. | A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis. Choi SY, Huang P, Jenkins GM, Chan DC, Schiller J, Frohman MA. | 12/7/2009 |