We describe a new regulatory mechanism, where an unreported lncRNA, PTPRE-AS1, targets receptor-type tyrosine protein phosphatase epsilon (PTPRE) to regulate macrophage activation. | LncRNA PTPRE-AS1 modulates M2 macrophage activation and inflammatory diseases by epigenetic promotion of PTPRE. Han X, Huang S, Xue P, Fu J, Liu L, Zhang C, Yang L, Xia L, Sun L, Huang SK, Zhou Y., Free PMC Article | 06/6/2020 |
GRB2 physically links cyt-PTPe with Src and enables cyt-PTPe to activate Src downstream of activated integrins in osteoclast-like cells. | Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase ϵ in osteoclasts. Levy-Apter E, Finkelshtein E, Vemulapalli V, Li SS, Bedford MT, Elson A., Free PMC Article | 04/18/2015 |
PTPs alpha and epsilon play distinct roles in osteoclasts. | Protein tyrosine phosphatases ε and α perform nonredundant roles in osteoclasts. Finkelshtein E, Lotinun S, Levy-Apter E, Arman E, den Hertog J, Baron R, Elson A., Free PMC Article | 01/24/2015 |
Multifaceted modulation of K+ channels by protein-tyrosine phosphatase epsilon tunes neuronal excitability. | Multifaceted modulation of K+ channels by protein-tyrosine phosphatase ε tunes neuronal excitability. Ebner-Bennatan S, Patrich E, Peretz A, Kornilov P, Tiran Z, Elson A, Attali B., Free PMC Article | 11/17/2012 |
Integrin activation regulates cyt-PTPe via Src-dependent Y638 phosphorylation. cyt-PTPe affects osteoclast podosome stability by a feedback loop ensuring proper Src activation downstream of integrins, linking their signaling with Src activation. | Protein tyrosine phosphatase epsilon regulates integrin-mediated podosome stability in osteoclasts by activating Src. Granot-Attas S, Luxenburg C, Finkelshtein E, Elson A., Free PMC Article | 04/12/2010 |
Findings demonstrate that PTPalpha is a critical regulator of Fyn activation and of specific Fyn signaling events during differentiation, and is essential for promoting OPC differentiation and central nervous system myelination. | Protein-tyrosine phosphatase alpha acts as an upstream regulator of Fyn signaling to promote oligodendrocyte differentiation and myelination. Wang PS, Wang J, Xiao ZC, Pallen CJ., Free PMC Article | 01/25/2010 |
Data suggest that PTPepsilon negatively regulates FcepsilonRI-mediated signalling pathways and thus constitutes a novel target for ameliorating allergic conditions. | Protein tyrosine phosphatase epsilon is a negative regulator of FcepsilonRI-mediated mast cell responses. Akimoto M, Mishra K, Lim KT, Tani N, Hisanaga SI, Katagiri T, Elson A, Mizuno K, Yakura H. | 01/21/2010 |
findings show that PTPe is expressed in erythrocytes & is involved in red cell signaling networks | PTPepsilon has a critical role in signaling transduction pathways and phosphoprotein network topology in red cells. De Franceschi L, Biondani A, Carta F, Turrini F, Laudanna C, Deana R, Brunati AM, Turretta L, Iolascon A, Perrotta S, Elson A, Bulato C, Brugnara C., Free PMC Article | 01/21/2010 |
Protein-tyrosine phosphatase epsilon regulates Shc signaling in a kinase-specific manner: increasing coherence in tyrosine phosphatase signaling | Protein-tyrosine phosphatase epsilon regulates Shc signaling in a kinase-specific manner: increasing coherence in tyrosine phosphatase signaling. Kraut-Cohen J, Muller WJ, Elson A. | 01/21/2010 |
cytosolic PTPepsilon serves as another major candidate negative regulator of insulin receptor signaling in skeletal muscle | Cytosolic protein tyrosine phosphatase-epsilon is a negative regulator of insulin signaling in skeletal muscle. Aga-Mizrachi S, Brutman-Barazani T, Jacob AI, Bak A, Elson A, Sampson SR. | 01/21/2010 |
Data show that association of protein tyrosine phosphatase epsilon with microtubules inhibits phosphatase activity and is regulated by the epidermal growth factor receptor. | Association of tyrosine phosphatase epsilon with microtubules inhibits phosphatase activity and is regulated by the epidermal growth factor receptor. Sines T, Granot-Attas S, Weisman-Welcher S, Elson A., Free PMC Article | 01/21/2010 |
PTPepsilon as a phosphatase required for optimal structure, subcellular organization, and function of osteoclasts | Tyrosine phosphatase epsilon is a positive regulator of osteoclast function in vitro and in vivo. Chiusaroli R, Knobler H, Luxenburg C, Sanjay A, Granot-Attas S, Tiran Z, Miyazaki T, Harmelin A, Baron R, Elson A., Free PMC Article | 01/21/2010 |
cyt-PTP epsilon is dimerized and phosphorylated in the absence of direct interaction between the PTP and extracellular molecules | Dimerization in vivo and inhibition of the nonreceptor form of protein tyrosine phosphatase epsilon. Toledano-Katchalski H, Tiran Z, Sines T, Shani G, Granot-Attas S, den Hertog J, Elson A., Free PMC Article | 01/21/2010 |
Receptor-like protein tyrosine phosphatase zeta/RPTP beta is expressed on tangentially aligned neurons in early mouse neocortex. | Receptor-like protein tyrosine phosphatase zeta/RPTP beta is expressed on tangentially aligned neurons in early mouse neocortex. Ohyama K, Ikeda E, Kawamura K, Maeda N, Noda M. | 01/21/2010 |
Protein tyrosine phosphatase epsilon activates Yes and Fyn in mammary tumor cells. | Protein tyrosine phosphatase epsilon activates Yes and Fyn in Neu-induced mammary tumor cells. Granot-Attas S, Elson A. | 01/21/2010 |
We conclude that PTPepsilon and PTPalpha differ significantly in their regulation of Kv channels and Src in the system examined and that similarity between PTPs does not necessarily result in full functional redundancy in vivo. | Tyrosine phosphatases epsilon and alpha perform specific and overlapping functions in regulation of voltage-gated potassium channels in Schwann cells. Tiran Z, Peretz A, Sines T, Shinder V, Sap J, Attali B, Elson A., Free PMC Article | 01/21/2010 |
RPTPepsilon is a physiological activator of Src in Neu-induced mammary tumors. | Tyrosine phosphatase-epsilon activates Src and supports the transformed phenotype of Neu-induced mammary tumor cells. Gil-Henn H, Elson A. | 01/21/2010 |