| PLXNA2 as a candidate gene in patients with intellectual disability. | PLXNA2 as a candidate gene in patients with intellectual disability.
Altuame FD, Shamseldin HE, Albatti TH, Hashem M, Ewida N, Abdulwahab F, Alkuraya FS. | 03/5/2022 |
| Here, biochemical analysis of NgR1 function uncovered a physical complex with CRMP cytoplasmic mediators, and this led to appreciation of a role for PlexinA2 in concert with NgR1 after adult spinal cord trauma. | Plexina2 and CRMP2 Signaling Complex Is Activated by Nogo-A-Liganded Ngr1 to Restrict Corticospinal Axon Sprouting after Trauma.
Sekine Y, Algarate PT, Cafferty WBJ, Strittmatter SM., Free PMC Article | 06/13/2020 |
| These findings implicate Semaphorin-6A - Plexin-A2/Plexin-A4 interactions in dorsal lateral geniculate nucleus axon guidance and in the spatiotemporal organization of guidepost cell populations in the mammalian subpallium. | Semaphorin-Plexin signaling influences early ventral telencephalic development and thalamocortical axon guidance.
Mitsogiannis MD, Little GE, Mitchell KJ., Free PMC Article | 03/31/2018 |
| describe procedures for protein production and purification that we utilized in the crystallographic study of the mouse Plexin A2 (mPlxnA2) extracellular fragment, including the sema domain | Immunoaffinity Purification of the Glycosylated Extracellular Fragment of Mouse Plexin A2 Produced in a Mammalian Expression System.
Nogi T, Mihara E, Yasui N, Takagi J. | 02/17/2018 |
| work reveals a 2-fold role of the PlxnA ectodomains: imposing a pre-signaling autoinhibitory separation for the cytoplasmic domains via intermolecular head-to-stalk interactions and supporting dimerization-based PlxnA activation upon ligand binding. | Structural Basis for Plexin Activation and Regulation.
Kong Y, Janssen BJ, Malinauskas T, Vangoor VR, Coles CH, Kaufmann R, Ni T, Gilbert RJ, Padilla-Parra S, Pasterkamp RJ, Jones EY., Free PMC Article | 07/8/2017 |
| Using time-lapse videomicroscopy we provide evidence that Sema6A/PlexinA2 signaling participates to interkinetic nuclear migration of retinal progenitor cell | PlexinA2 and Sema6A are required for retinal progenitor cell migration.
Belle M, Parray A, Belle M, Chédotal A, Nguyen-Ba-Charvet KT. | 02/18/2017 |
| Plexin A2 is expressed in both On and Off starburst amacrine cell. | On and off retinal circuit assembly by divergent molecular mechanisms.
Sun LO, Jiang Z, Rivlin-Etzion M, Hand R, Brady CM, Matsuoka RL, Yau KW, Feller MB, Kolodkin AL., Free PMC Article | 11/16/2013 |
| results of our study reveal that PlxnA2 has a pro-osteogenic function by modulating BMP2 signaling | PlexinA2 mediates osteoblast differentiation via regulation of Runx2.
Oh JE, Kim HJ, Kim WS, Lee ZH, Ryoo HM, Hwang SJ, Lee Y, Kim HH. | 07/21/2012 |
| crystal structures of cognate complexes of the semaphorin-binding regions of plexins B1 and A2 with semaphorin ectodomains (human PLXNB1(1-2)-SEMA4D(ecto) and murine PlxnA2(1-4)-Sema6A(ecto)), plus unliganded structures of PlxnA2(1-4) and Sema6A(ecto) | Structural basis of semaphorin-plexin signalling.
Janssen BJ, Robinson RA, Pérez-Brangulí F, Bell CH, Mitchell KJ, Siebold C, Jones EY., Free PMC Article | 01/1/2011 |
| crystal structures of the semaphorin 6A (Sema6A) receptor-binding fragment and the plexin A2 (PlxnA2) ligand-binding fragment in both their pre-signalling (that is, before binding) and signalling (after complex formation) states | Structural basis for semaphorin signalling through the plexin receptor.
Nogi T, Yasui N, Mihara E, Matsunaga Y, Noda M, Yamashita N, Toyofuku T, Uchiyama S, Goshima Y, Kumanogoh A, Takagi J. | 01/1/2011 |
| This study demonstrated that Sema6B, another class 6 transmembrane semaphorin, is expressed in CA3 and repels mossy fibers in a PlxnA4-dependent manner in vitro. | Roles of semaphorin-6B and plexin-A2 in lamina-restricted projection of hippocampal mossy fibers.
Tawarayama H, Yoshida Y, Suto F, Mitchell KJ, Fujisawa H., Free PMC Article | 06/14/2010 |
| mutations in GATA6 are genetic causes of congenital heart diseases involving outflow tract defects, as a result of the disruption of the direct regulation of semaphorin 3C-plexin A2 signaling | GATA6 mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin signaling.
Kodo K, Nishizawa T, Furutani M, Arai S, Yamamura E, Joo K, Takahashi T, Matsuoka R, Yamagishi H., Free PMC Article | 01/21/2010 |
| In plexin-A2-deficient mice many granule cells remained in the molecular layer; mouse chimera studies further suggested that plexin-A2 acts in a cell-autonomous manner. | Plexin-A2 and its ligand, Sema6A, control nucleus-centrosome coupling in migrating granule cells.
Renaud J, Kerjan G, Sumita I, Zagar Y, Georget V, Kim D, Fouquet C, Suda K, Sanbo M, Suto F, Ackerman SL, Mitchell KJ, Fujisawa H, Chédotal A. | 01/21/2010 |