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    Mbp myelin basic protein [ Mus musculus (house mouse) ]

    Gene ID: 17196, updated on 6-Aug-2017

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    to further characterize the mechanism regulating mbp transcription, study defined M3 structure/function relationships; multiple M3 regulatory element combinations were found to drive expression in oligodendrocytes and Schwann cells with a minimal 129 bp sequence conferring expression in oligodendrocytes throughout myelin elaboration, maintenance and repair

    Functional organization of an Mbp enhancer exposes striking transcriptional regulatory diversity within myelinating glia.
    Dionne N, Dib S, Finsen B, Denarier E, Kuhlmann T, Drouin R, Kokoeva M, Hudson TJ, Siminovitch K, Friedman HC, Peterson AC.

    Results show the expression of sncRNA715 in Schwann cells and its inverse correlation with Mbp mRNA in cultured cells and the sciatic nerve. Its inhibitory effect on MBP was confirmed in differentiating primary Schwann cells.

    SncRNA715 Inhibits Schwann Cell Myelin Basic Protein Synthesis.
    Müller C, Hochhaus NM, Fontana X, Luhmann HJ, White R., Free PMC Article

    Results suggest that GAL is a regulator of myelination, as demonstrated by MBP synthesis, and may be one of the myelination promoters

    An elevated level of circulating galanin promotes developmental expression of myelin basic protein in the mouse brain.
    Lyubetska H, Zhang L, Kong J, Vrontakis M.

    Data indicate that 18.5 kDa myelin basic protein (MBP) segment upstream of the primary SH3-ligand is involved in interaction.

    The proline-rich region of 18.5 kDa myelin basic protein binds to the SH3-domain of Fyn tyrosine kinase with the aid of an upstream segment to form a dynamic complex in vitro.
    De Avila M, Vassall KA, Smith GS, Bamm VV, Harauz G., Free PMC Article

    Data suggest that prenatal alterations in expression of various fetal brain proteins (including up-regulation of Mbp) are associated with aberrant behavioral characteristics of transgenic mice that model autism-like behavior.

    Altered expression levels of neurodevelopmental proteins in fetal brains of BTBR T+tf/J mice with autism-like behavioral characteristics.
    Hwang SR, Kim CY, Shin KM, Jo JH, Kim HA, Heo Y.

    Data suggest that hybrid protein composed of two different Myelin basic protein (MBP) isoforms (TandeMBP) might become a tool for in vitro assays to analyse various protein kinase activities.

    TandeMBP: generation of a unique protein substrate for protein kinase assays.
    Kameshita I, Yamashita S, Katayama S, Senga Y, Sueyoshi N.

    Data indicate a role for myelin basic protein (MBP) isoforms in protein-protein interactions during membrane and cytoskeletal extension and remodeling in oligodendrocytes (OLGs).

    Interaction of myelin basic protein with cytoskeletal and signaling proteins in cultured primary oligodendrocytes and N19 oligodendroglial cells.
    Boggs JM, Homchaudhuri L, Ranagaraj G, Liu Y, Smith GS, Harauz G., Free PMC Article

    Disappearance of 21.5 pMBP corresponded to demyelination and its reappearance corresponded to prevention of demyelination.

    Phase separation of myelin sheath in Triton X-114 solution: predominant localization of the 21.5-kDa isoform of myelin basic protein in the lipid raft-associated domain.
    Uruse M, Yamamoto M, Sugawa M, Matsuura K, Sato Y, Seiwa C, Watanabe K, Aiso S, Asou H.

    Golli-BG21 enhanced SCP1/GIP phosphatase activity, whereas PKCalpha-phosphorylated BG21 inhibited its activity, suggesting a potential role of BG21 as a molecular switch ("quick-brake mechanism") on SCP1/GIP.

    Regulatory effect of the glial Golli-BG21 protein on the full-length murine small C-terminal domain phosphatase (SCP1, or Golli-interacting protein).
    Jaramillo-Tatis S, Vassall KA, Bamm VV, Harauz G.

    Myelin basic protein cleaves cell adhesion molecule L1 and promotes neuritogenesis and cell survival.

    Myelin basic protein cleaves cell adhesion molecule L1 and promotes neuritogenesis and cell survival.
    Lutz D, Loers G, Kleene R, Oezen I, Kataria H, Katagihallimath N, Braren I, Harauz G, Schachner M., Free PMC Article

    MBP expression in cultured Fmr1 KO oligodendrocytes is similar to wild type, and expression of MBP in brain homogenates of the Fmr1 KO mouse to be similar to wild type.

    FMRP and myelin protein expression in oligodendrocytes.
    Giampetruzzi A, Carson JH, Barbarese E., Free PMC Article

    myelin basic protein drives myelin biogenesis using weak forces arising from its inherent capacity to phase separate.

    Myelin membrane assembly is driven by a phase transition of myelin basic proteins into a cohesive protein meshwork.
    Aggarwal S, Snaidero N, Pähler G, Frey S, Sánchez P, Zweckstetter M, Janshoff A, Schneider A, Weil MT, Schaap IA, Görlich D, Simons M., Free PMC Article

    Myelin basic protein-21.5 kDa in the nucleus promotes oligodendrocyte proliferation, while melin basic protein-18.5-kDa in plasma membrane does not.

    Nucleus-localized 21.5-kDa myelin basic protein promotes oligodendrocyte proliferation and enhances neurite outgrowth in coculture, unlike the plasma membrane-associated 18.5-kDa isoform.
    Smith GS, Samborska B, Hawley SP, Klaiman JM, Gillis TE, Jones N, Boggs JM, Harauz G., Free PMC Article

    21.5-kDa MBP contains two non-traditional PY-nuclear-localization signals, and arginine and lysine residues within these motifs were involved in subcellular trafficking of this protein to the nucleus, where it may have functional roles during myelinogenesis.

    The 21.5-kDa isoform of myelin basic protein has a non-traditional PY-nuclear-localization signal.
    Smith GS, Seymour LV, Boggs JM, Harauz G., Free PMC Article

    Loss of MBP is associated with aging and hearing loss.

    Age-related changes of myelin basic protein in mouse and human auditory nerve.
    Xing Y, Samuvel DJ, Stevens SM, Dubno JR, Schulte BA, Lang H., Free PMC Article

    Myelin basic protein (MBP) performs distinct actions on the formation, maturation, degeneration and regeneration of sciatic nerve myelin sheath.

    Age-related changes in myelin morphology, electrophysiological property and myelin-associated protein expression of mouse sciatic nerves.
    Shen D, Zhang Q, Gao X, Gu X, Ding F.

    Regulation of the Mbp gene, along with the relative amount of expressed Mbp protein, suggests that the immortalized cell lines containing them are representative of immature oligodendrocytes.

    Expression of myelin genes: comparative analysis of Oli-neu and N20.1 oligodendroglial cell lines.
    Pereira GB, Dobretsova A, Hamdan H, Wight PA., Free PMC Article

    The results of this study suggested that MBP's SH3 ligand domain plays a key role in intracellular protein interactions in vivo and may be required for proper membrane elaboration of developing oligodendrocytes.

    Proline substitutions and threonine pseudophosphorylation of the SH3 ligand of 18.5-kDa myelin basic protein decrease its affinity for the Fyn-SH3 domain and alter process development and protein localization in oligodendrocytes.
    Smith GS, De Avila M, Paez PM, Spreuer V, Wills MK, Jones N, Boggs JM, Harauz G., Free PMC Article

    Molecular dynamics simulations were conducted to investigate the conformation of the immunodominant epitope of acetylated myelin basic protein residues 1-11 and its altered peptide ligands, mutated at position 4 to an alanine or a tyrosine residue.

    Conformational studies of immunodominant myelin basic protein 1-11 analogues using NMR and molecular modeling.
    Laimou D, Lazoura E, Troganis AN, Matsoukas MT, Deraos SN, Katsara M, Matsoukas J, Apostolopoulos V, Tselios TV.

    define hnRNP F as a regulatory element of MBP expression in oligodendrocytes and imply an important function of hnRNP F in the control of myelin synthesis.

    Heterogeneous nuclear ribonucleoprotein (hnRNP) F is a novel component of oligodendroglial RNA transport granules contributing to regulation of myelin basic protein (MBP) synthesis.
    White R, Gonsior C, Bauer NM, Krämer-Albers EM, Luhmann HJ, Trotter J., Free PMC Article

    there is an N-terminal binding domain in MBP for Ca(2+)-CaM

    Structured functional domains of myelin basic protein: cross talk between actin polymerization and Ca(2+)-dependent calmodulin interaction.
    Bamm VV, De Avila M, Smith GS, Ahmed MA, Harauz G., Free PMC Article

    Human umbilical cord blood-derived mesenchymal stem cells upregulate myelin basic protein in shiverer mice.

    Human umbilical cord blood-derived mesenchymal stem cells upregulate myelin basic protein in shiverer mice.
    Veeravalli KK, Dasari VR, Fassett D, Dinh DH, Rao JS.

    our data indicate a key role for golli proteins in the regulation of TRPC-mediated Ca(2+) influx

    Modulation of canonical transient receptor potential channel 1 in the proliferation of oligodendrocyte precursor cells by the golli products of the myelin basic protein gene.
    Paez PM, Fulton D, Spreuer V, Handley V, Campagnoni AT., Free PMC Article

    The density of high-voltage-activated currents is reduced in oligodendroglial precursor cells recorded in golli-deficient tissue, while low-voltage-activated currents remain unaltered in these cells.

    Regulation of L-type Ca++ currents and process morphology in white matter oligodendrocyte precursor cells by golli-myelin proteins.
    Fulton D, Paez PM, Fisher R, Handley V, Colwell CS, Campagnoni AT.

    The QKI-6 RNA binding protein localizes with the MBP mRNAs in stress granules of glial cells.

    The QKI-6 RNA binding protein localizes with the MBP mRNAs in stress granules of glial cells.
    Wang Y, Lacroix G, Haines J, Doukhanine E, Almazan G, Richard S., Free PMC Article

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