| IL-7 Deficiency Exacerbates Atopic Dermatitis in NC/Nga Mice. | IL-7 Deficiency Exacerbates Atopic Dermatitis in NC/Nga Mice.
Park HJ, Lee SW, Van Kaer L, Lee MS, Hong S., Free PMC Article | 06/30/2023 |
| Interleukin-7 aggravates myocardial ischaemia/reperfusion injury by regulating macrophage infiltration and polarization. | Interleukin-7 aggravates myocardial ischaemia/reperfusion injury by regulating macrophage infiltration and polarization.
Yan M, Yang Y, Zhou Y, Yu C, Li R, Gong W, Zheng J., Free PMC Article | 03/19/2022 |
| The Broad Immunomodulatory Effects of IL-7 and Its Application In Vaccines. | The Broad Immunomodulatory Effects of IL-7 and Its Application In Vaccines.
Huang J, Long Z, Jia R, Wang M, Zhu D, Liu M, Chen S, Zhao X, Yang Q, Wu Y, Zhang S, Tian B, Mao S, Ou X, Sun D, Gao Q, Cheng A., Free PMC Article | 03/5/2022 |
| Selective dependence on IL-7 for antigen-specific CD8 T cell responses during airway influenza infection. | Selective dependence on IL-7 for antigen-specific CD8 T cell responses during airway influenza infection.
Sheikh A, Jackson J, Shim HB, Yau C, Seo JH, Abraham N., Free PMC Article | 02/26/2022 |
| In vivo availability of the cytokine IL-7 constrains the survival and homeostasis of peripheral iNKT cells. | In vivo availability of the cytokine IL-7 constrains the survival and homeostasis of peripheral iNKT cells.
Park JY, Won HY, DiPalma DT, Kim HK, Kim TH, Li C, Sato N, Hong C, Abraham N, Gress RE, Park JH., Free PMC Article | 02/19/2022 |
| Interleukin-7 protects CD8(+) T cells from adenosine-mediated immunosuppression. | Interleukin-7 protects CD8(+) T cells from adenosine-mediated immunosuppression.
Koyas A, Tucer S, Kayhan M, Savas AC, Akdemir I, Cekic C. | 01/22/2022 |
| Prosurvival IL-7-Stimulated Weak Strength of mTORC1-S6K Controls T Cell Memory via Transcriptional FOXO1-TCF1-Id3 and Metabolic AMPKalpha1-ULK1-ATG7 Pathways. | Prosurvival IL-7-Stimulated Weak Strength of mTORC1-S6K Controls T Cell Memory via Transcriptional FOXO1-TCF1-Id3 and Metabolic AMPKα1-ULK1-ATG7 Pathways.
Xu A, Leary SC, Islam MF, Wu Z, Bhanumathy KK, Ara A, Chibbar R, Fleywald A, Ahmed KA, Xiang J. | 01/15/2022 |
| IL-2/IL-7-inducible factors pioneer the path to T cell differentiation in advance of lineage-defining factors. | IL-2/IL-7-inducible factors pioneer the path to T cell differentiation in advance of lineage-defining factors.
Bevington SL, Keane P, Soley JK, Tauch S, Gajdasik DW, Fiancette R, Matei-Rascu V, Willis CM, Withers DR, Cockerill PN., Free PMC Article | 04/17/2021 |
| Interleukin-7 protects against bacterial respiratory infection by promoting IL-17A-producing innate T-cell response. | Interleukin-7 protects against bacterial respiratory infection by promoting IL-17A-producing innate T-cell response.
Hassane M, Jouan Y, Creusat F, Soulard D, Boisseau C, Gonzalez L, Patin EC, Heuzé-Vourc'h N, Sirard JC, Faveeuw C, Trottein F, Si-Tahar M, Baranek T, Paget C. | 01/9/2021 |
| IL-7 derived from lymph node fibroblastic reticular cells is dispensable for naive T cell homeostasis but crucial for central memory T cell survival. | IL-7 derived from lymph node fibroblastic reticular cells is dispensable for naive T cell homeostasis but crucial for central memory T cell survival.
Knop L, Deiser K, Bank U, Witte A, Mohr J, Philipsen L, Fehling HJ, Müller AJ, Kalinke U, Schüler T. | 12/12/2020 |
| Inducible IL-7 Hyperexpression Influences Lymphocyte Homeostasis and Function and Increases Allograft Rejection. | Inducible IL-7 Hyperexpression Influences Lymphocyte Homeostasis and Function and Increases Allograft Rejection.
Schreiber M, Weigelt M, Karasinsky A, Anastassiadis K, Schallenberg S, Petzold C, Bonifacio E, Kretschmer K, Hommel A., Free PMC Article | 09/19/2020 |
| IL-7-dependent compositional changes within the gamma-delta T cell pool in lymph nodes during ageing lead to an unbalanced anti-tumour response. | IL-7-dependent compositional changes within the γδ T cell pool in lymph nodes during ageing lead to an unbalanced anti-tumour response.
Chen HC, Eling N, Martinez-Jimenez CP, O'Brien LM, Carbonaro V, Marioni JC, Odom DT, de la Roche M., Free PMC Article | 05/2/2020 |
| Increased IL-7 expression in the macrophages in S. japonicum-infected mice. IL-7-IL-7R signalling suppresses macrophage autophagy in S. japonicum-infected mice.IL-7 suppresses macrophage autophagy via AMPK. | IL-7 suppresses macrophage autophagy and promotes liver pathology in Schistosoma japonicum-infected mice.
Zhu J, Zhang W, Zhang L, Xu L, Chen X, Zhou S, Xu Z, Xiao M, Bai H, Liu F, Su C., Free PMC Article | 12/14/2019 |
| Data indicate that combined over-expression of interleukin 7 (IL-7) and FMS-like tyrosine kinase 3 ligand (FL) leads to a massive expansion of most bone marrow hematopoietic progenitors. | Accumulation of Multipotent Hematopoietic Progenitors in Peripheral Lymphoid Organs of Mice Over-expressing Interleukin-7 and Flt3-Ligand.
Klein F, von Muenchow L, Capoferri G, Heiler S, Alberti-Servera L, Rolink H, Engdahl C, Rolink M, Mitrovic M, Cvijetic G, Andersson J, Ceredig R, Tsapogas P, Rolink A., Free PMC Article | 10/5/2019 |
| IL-7/IL-7R can promote RANKL-mediated osteoclast formation and bone resorption by activating the c-Fos/c-Jun pathway. | Effects of interleukin-7/interleukin-7 receptor on RANKL-mediated osteoclast differentiation and ovariectomy-induced bone loss by regulating c-Fos/c-Jun pathway.
Zhao JJ, Wu ZF, Yu YH, Wang L, Cheng L. | 10/5/2019 |
| REVIEW: IL-7 and Its Beneficial Role in Sepsis-Induced T Lymphocyte Dysfunction | IL-7 and Its Beneficial Role in Sepsis-Induced T Lymphocyte Dysfunction.
de Roquetaillade C, Monneret G, Gossez M, Venet F. | 09/21/2019 |
| maintenance of intact lymph nodes relies on IL-7-dependent maintenance of innate lymphoid cells. | IL-7-dependent maintenance of ILC3s is required for normal entry of lymphocytes into lymph nodes.
Yang J, Cornelissen F, Papazian N, Reijmers RM, Llorian M, Cupedo T, Coles M, Seddon B., Free PMC Article | 06/22/2019 |
| IL-7 stimulation inhibited nephrin activation and caused actin cytoskeleton disorganization, indicating that IL-7 stimulation induces podocyte injury. | Interleukin-7 stimulation inhibits nephrin activation and induces podocyte injury.
Zhai S, Zhao L, Zhang Y, Ma Q. | 05/18/2019 |
| We have demonstrated an essential role of IL-7 and TGF-beta in the generation of thymus-derived Tregs in the co-culture of thymocytes and JAWS II cells. In addition, in vitro generated Tregs exhibited their suppressive function similarly to Tregs sorted from freshly isolated thymus. | A new approach to the role of IL-7 and TGF-ß in the in vitro generation of thymus-derived CD4+CD25+Foxp3+ regulatory T cells.
Bieńkowska A, Kiernozek E, Kozlowska E, Bugajski Ł, Drela N. | 02/2/2019 |
| We engineered CAR-T cells to express interleukin (IL)-7 and CCL19 (7 x 19 CAR-T cells), as these factors are essential for the maintenance of T-cell zones in lymphoid organs... Following treatment of mice with 7 x 19 CAR-T cells, both recipient conventional T cells and administered CAR-T cells generated memory responses against tumors. | IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor.
Adachi K, Kano Y, Nagai T, Okuyama N, Sakoda Y, Tamada K. | 12/22/2018 |
| A key role of the IL7 and Interferon type I receptor axis in the regulation of intratumoral t-cell functions and in the development of primary breast tumor growth and metastasis. | Type I IFN Receptor Signaling Controls IL7-Dependent Accumulation and Activity of Protumoral IL17A-Producing γδT Cells in Breast Cancer.
Patin EC, Soulard D, Fleury S, Hassane M, Dombrowicz D, Faveeuw C, Trottein F, Paget C. | 11/10/2018 |
| BMP4 and IL7 appear to be involved in the interaction between intestinal epithelial cells and intestinal epithelial cells and in the mechanism underlying intestinal mucosal barrier dysfunction. | The interplay of BMP4 and IL‑7 regulates the apoptosis of intestinal intraepithelial lymphocytes under conditions of ischemia̸reperfusion.
Luo B, Chen K, Feng Q, Xiao W, Ma D, Yang H, Zhang C., Free PMC Article | 09/1/2018 |
| This finding warrants future development of IL-21 and IL-7 co-expressing whole-cell cancer vaccines and their relevant combinatorial regimens. | Forced co-expression of IL-21 and IL-7 in whole-cell cancer vaccines promotes antitumor immunity.
Gu YZ, Fan CW, Lu R, Shao B, Sang YX, Huang QR, Li X, Meng WT, Mo XM, Wei YQ., Free PMC Article | 06/2/2018 |
| both Flt3 ligand (FL) and IL-7 regulate B-cell commitment in a permissive manner: FL by inducing proliferation of Ly6D(+)CD135(+)CD127(+)CD19(-) progenitors and IL-7 by providing survival signals to these progenitors | Permissive roles of cytokines interleukin-7 and Flt3 ligand in mouse B-cell lineage commitment.
von Muenchow L, Alberti-Servera L, Klein F, Capoferri G, Finke D, Ceredig R, Rolink A, Tsapogas P., Free PMC Article | 04/7/2018 |
| the in vivo biological role of m(6)A modification in T-cell-mediated pathogenesis and reveals a novel mechanism of T cell homeostasis and Il-7 signal-dependent induction of mRNA degradation | m(6)A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways.
Li HB, Tong J, Zhu S, Batista PJ, Duffy EE, Zhao J, Bailis W, Cao G, Kroehling L, Chen Y, Wang G, Broughton JP, Chen YG, Kluger Y, Simon MD, Chang HY, Yin Z, Flavell RA., Free PMC Article | 01/27/2018 |