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    Igf1r insulin-like growth factor I receptor [ Mus musculus (house mouse) ]

    Gene ID: 16001, updated on 11-Jun-2019

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Study determined that IGF1R is essential in tumor suppression in breast tumorigenesis. Attenuated IGF1R signaling in the MMTV-Wnt1 mouse mammary tumor model and in human breast cancer cell lines increases tumor epithelial cellular stress, resulting in upregulation of cytokine production promoting an aggressive tumor microenvironment through infiltration of immune cells and matrix remodeling.

    Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment.
    Obr AE, Kumar S, Chang YJ, Bulatowicz JJ, Barnes BJ, Birge RB, Lazzarino DA, Gallagher E, LeRoith D, Wood TL., Free PMC Article

    results point to a new TTR role through the IGF-I axis, mediated through TTR-IGF-IR interactions.

    Evidence for synergistic action of transthyretin and IGF-I over the IGF-I receptor.
    Vieira M, Leal SS, Gomes CM, Saraiva MJ.

    Astrocyte-specific knockout of IGFR impaired working memory, mitochondrial metabolism, and amyloid-beta uptake.

    Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes.
    Logan S, Pharaoh GA, Marlin MC, Masser DR, Matsuzaki S, Wronowski B, Yeganeh A, Parks EE, Premkumar P, Farley JA, Owen DB, Humphries KM, Kinter M, Freeman WM, Szweda LI, Van Remmen H, Sonntag WE., Free PMC Article

    IGF-1R is necessary for the early orientation and polarity switch of cortical plate neurons and, therefore, for normal neuron migration and differentiation, including axonal outgrowth and the establishment of neuronal polarity.

    IGF-1 receptor regulates dynamic changes in neuronal polarity during cerebral cortical migration.
    Nieto Guil AF, Oksdath M, Weiss LA, Grassi DJ, Sosa LJ, Nieto M, Quiroga S., Free PMC Article

    Results suggest that insulin-like growth factor 1 receptor (IGF1R) signaling plays an important role in regulating embryonic epicardial cells (EPCs) proliferation, and this effect may be mediated by focal adhesion kinase (FAK) pathway.

    Insulin-like growth factor 1 receptor signaling regulates embryonic epicardial cell proliferation through focal adhesion kinase pathway.
    Yan Y, Qin Q, Wu L, Jing X, Deng S, She Q.

    Cell-lineage tracing revealed progenitor Leydig cell enrichment is secondary to Insr and Igf1r deletion in differentiated adult Leydig cell , suggesting a feedback mechanism between cells at different steps of differentiation.

    Insulin and IGF1 receptors are essential for the development and steroidogenic function of adult Leydig cells.
    Neirijnck Y, Calvel P, Kilcoyne KR, Kühne F, Stévant I, Griffeth RJ, Pitetti JL, Andric SA, Hu MC, Pralong F, Smith LB, Nef S.

    we demonstrated that hypoxia significantly induced the GSC mesenchymal transition, increased the expression levels of the pluripotent transcription factor OCT4 and migration-associated proteins..he underlying mechanism involved significant IGF-1/IGF-1R activation of OCT4/CXCR4 expression through HIF-2alpha regulation.

    IGF-1R Promotes Symmetric Self-Renewal and Migration of Alkaline Phosphatase<sup>+</sup> Germ Stem Cells through HIF-2α-OCT4/CXCR4 Loop under Hypoxia.
    Kuo YC, Au HK, Hsu JL, Wang HF, Lee CJ, Peng SW, Lai SC, Wu YC, Ho HN, Huang YH., Free PMC Article

    High IGF1R expression is associated with colorectal cancer.

    Radiotherapy-Activated Cancer-Associated Fibroblasts Promote Tumor Progression through Paracrine IGF1R Activation.
    Tommelein J, De Vlieghere E, Verset L, Melsens E, Leenders J, Descamps B, Debucquoy A, Vanhove C, Pauwels P, Gespach CP, Vral A, De Boeck A, Haustermans K, de Tullio P, Ceelen W, Demetter P, Boterberg T, Bracke M, De Wever O.

    These findings identify IGF1R as an important player in murine acute lung inflammation, suggesting that targeting IGF1R may counteract the inflammatory component of many lung diseases.

    IGF1R deficiency attenuates acute inflammatory response in a bleomycin-induced lung injury mouse model.
    Piñeiro-Hermida S, López IP, Alfaro-Arnedo E, Torrens R, Iñiguez M, Alvarez-Erviti L, Ruíz-Martínez C, Pichel JG., Free PMC Article

    IGF-1R signalling contributes to T cell dependent inflammation in arthritis. Inhibition of IGF-1R on the level of insulin receptor substrates alleviates arthritis by restricting IL6-dependent formation of Th17 cells and may open for new treatment strategies in rheumatoid arthritis.

    IGF-1R signalling contributes to IL-6 production and T cell dependent inflammation in rheumatoid arthritis.
    Erlandsson MC, Töyrä Silfverswärd S, Nadali M, Turkkila M, Svensson MND, Jonsson IM, Andersson KME, Bokarewa MI.

    These results suggested that appropriate WBV may delay the progression of AS, which was associated with acutely elevated serum IGF-1 and lower levels of IGF-1 and IL-6 in the aorta for long-term treatment.

    Whole Body Vibration Retards Progression of Atherosclerosis via Insulin-Like Growth Factor 1 in Apolipoprotein E-Deficient Mice.
    Wu H, Zhang Y, Yang X, Li X, Shao Z, Zhou Z, Li Y, Pan S, Liu C., Free PMC Article

    Study showed the significance of TLR4 in upregulation of MAPK/ErK in NMDAR hypofunction schizophrenic-mouse model. This is characterized by a decrease in hippocampal IGF-1R/CaMKIIalpha, and social interaction behavioral deficits. Ultimately, hippocampal TLR4 knockdown rescued IGF-1R/CaMKIIalpha decline and prevented behavioral deficits by reducing MAPK/ErK expression.

    CaMKIIα expression in a mouse model of NMDAR hypofunction schizophrenia: Putative roles for IGF-1R and TLR4.
    Ogundele OM, Lee CC., Free PMC Article

    Expression of IGF-1 and LEPR indicates a relevant role in androgenic features reversion present in PCOS, hormonal equilibrium, body weight regulation, and glucose metabolism, therefore, under phenotype obesity and infertility regulation in this model.

    IGF-1R and Leptin Expression Profile and the Effects of Metformin Treatment on Metabolic and Endocrine Parameters in PCOS Mice.
    Prado Correia LE, de Almeida BC, de Jesus Simões M, Abi Haidar M, Berguio Vidotti D, Silva I., Free PMC Article

    diabetic gastroparesis was an aggressive process due to the successive damages of myenteric cholinergic neurones and ICC by impairing the insulin/InsR and IGF-1/IGF-1R signaling. Insulin therapy in the early stage may delay diabetic gastroparesis

    Impaired insulin/IGF-1 is responsible for diabetic gastroparesis by damaging myenteric cholinergic neurones and interstitial cells of Cajal.
    Yang S, Wu B, Sun H, Sun T, Han K, Li D, Ji F, Zhang G, Zhou D., Free PMC Article

    Data identify central IGF-1R as a mediator of the integration of nutrient and temperature homeostasis. They also show that calorie restriction, IGF-1R signaling, and body temperature, three of the main regulators of metabolism, aging, and longevity, are components of the same pathway.

    Insulin-like growth factor 1 receptor regulates hypothermia during calorie restriction.
    Cintron-Colon R, Sanchez-Alavez M, Nguyen W, Mori S, Gonzalez-Rivera R, Lien T, Bartfai T, Aïd S, François JC, Holzenberger M, Conti B., Free PMC Article

    RIP3 and phosphorylated MLKL expressions were relatively decreased in the IGF-1 receptor monoclonal antibody group compared to the non-treated group. IGF-1 may be associated with RIP3-mediated necroptosis in vitro, while blocking of the IGF-1 pathway may reduce LPS-induced lung injuries in vivo.

    Inhibition of insulin-like growth factor receptor-1 reduces necroptosis-related markers and attenuates LPS-induced lung injury in mice.
    Lee SH, Shin JH, Song JH, Leem AY, Park MS, Kim YS, Chang J, Chung KS.

    Data (including data from studies in knockout mice) suggest double knockout (DKO) mice lacking Insr and Igf1r exhibit obesity with insulin resistance and increased adiposity; on high-fat diet, DKO mice exhibit metabolic syndrome. (Insr = insulin receptor; Igf1r = insulin-like growth factor I receptor)

    Male Brown Fat-Specific Double Knockout of IGFIR/IR: Atrophy, Mitochondrial Fission Failure, Impaired Thermogenesis, and Obesity.
    Viana-Huete V, Guillén C, García G, Fernández S, García-Aguilar A, Kahn CR, Benito M., Free PMC Article

    results demonstrate for the first time that Igf1r is important in acute asthma pathobiology and resolution of HDM-induced inflammation

    Characterization of the acute inflammatory profile and resolution of airway inflammation after Igf1r-gene targeting in a murine model of HDM-induced asthma.
    Piñeiro-Hermida S, Alfaro-Arnedo E, Gregory JA, Torrens R, Ruíz-Martínez C, Adner M, López IP, Pichel JG., Free PMC Article

    This study found that expressions of Cav3.2 and IGF-1R, and their colocalization were not increased in DRGs of mice following axotomy. In addition, Cav3.2 or IGF-1R subpopulation neurons did not acquire significant switch in expression phenotype after sciatic nerve axotomy.

    Expression patterns of T-type Cav3.2 channel and insulin-like growth factor-1 receptor in dorsal root ganglion neurons of mice after sciatic nerve axotomy.
    Lin SF, Yu XL, Liu XY, Wang B, Li CH, Sun YG, Liu XJ.

    The present observations indicate that IGF-IR regulates glucose transporter 1 activity in astrocytes.

    The insulin-like growth factor I receptor regulates glucose transport by astrocytes.
    Hernandez-Garzón E, Fernandez AM, Perez-Alvarez A, Genis L, Bascuñana P, Fernandez de la Rosa R, Delgado M, Angel Pozo M, Moreno E, McCormick PJ, Santi A, Trueba-Saiz A, Garcia-Caceres C, Tschöp MH, Araque A, Martin ED, Torres Aleman I.

    Epithelial IGF1R is dispensable for IGF2-mediated enhanced intestinal adaptation after small bowel resection in retinoblastoma-deficient mice.

    Epithelial IGF1R is dispensable for IGF2 mediated enhanced intestinal adaptation in retinoblastoma-deficient mice.
    Sun RC, Choi PM, Diaz-Miron JL, Sommovilla J, Guo J, Erwin CR, Warner BW., Free PMC Article

    these data suggest that the decreased mammary gland tumor latency time caused by chronic IGF1R activation is related to modulation of tumor progression rather than increased tumor initiation.

    Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production.
    Ter Braak B, Siezen CL, Lee JS, Rao P, Voorhoeve C, Ruppin E, van der Laan JW, van de Water B., Free PMC Article

    data show that the GSK3B-FOXO3 pathway is activated after partial hepatectomy, and this may be one of the mechanisms that lead to upregulation of hepatic IGF1R after partial hepatectomy.

    Hepatic insulin-like growth factor receptor is upregulated by activation of the GSK3B-FOXO3 pathway after partial hepatectomy.
    E CY, Cai Y, Sun BZ, Guan LY, Jiang T.

    Data show that tumors lacking PSMA had less than half the abundance of type 1 insulin-like growth factor receptor (IGF-1R), less activity in the survival pathway mediated by PI3K-AKT signaling, and more activity in the proliferative pathway mediated by MAPK-ERK1/2 signaling.

    PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer.
    Caromile LA, Dortche K, Rahman MM, Grant CL, Stoddard C, Ferrer FA, Shapiro LH., Free PMC Article

    let-7g regulates autophagy in mouse granulosa cells by targeting insulin-like growth factor 1 receptor and downregulating protein kinase B/mammalian target of rapamycin signaling

    MicroRNA let-7g regulates mouse granulosa cell autophagy by targeting insulin-like growth factor 1 receptor.
    Zhou J, Yao W, Liu K, Wen Q, Wu W, Liu H, Li Q.

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